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Karyopharm Therapeutics Inc.

$1.57 -$5.62 (-78.10%)
NASDAQ · 14 Sep 2026 14:19 UTC
Previous Close
$1.61
Day Range
$1.55$1.62
Year Range
$1.24$10.99
Market Cap
35.68M
AVG Volume
1.17M
Trailing/Forward PE
-0.07/-
PEG ratio
0
Dividend Yield
-
Next Earnings Date
2026-11-02
Primary Exchange
NASDAQUS
Revenue (USD) · TTM
050M100M150M200M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Revenue (USD) · TTM by quarter
PeriodRevenue (USD) · TTM
26 Q2146.62M
26 Q1151.12M
25 Q4146.07M
25 Q3142.53M
25 Q2137.27M
25 Q1142.13M
24 Q4145.24M
24 Q3148.44M
24 Q2145.67M
24 Q1140.46M
Net Income (USD) · TTM
-300M-200M-100M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Net Income (USD) · TTM by quarter
PeriodNet Income (USD) · TTM
26 Q2-224.74M
26 Q1-194.97M
25 Q4-196.04M
25 Q3-124.62M
25 Q2-123.57M
25 Q1-62.52M
24 Q4-76.42M
24 Q3-87.48M
24 Q2-89.91M
24 Q1-146.34M
Operating Income (USD) · TTM
-150M-100M-50M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Operating Income (USD) · TTM by quarter
PeriodOperating Income (USD) · TTM
26 Q2-82.35M
26 Q1-84.21M
25 Q4-90.71M
25 Q3-104.14M
25 Q2-115.21M
25 Q1-118.94M
24 Q4-119.44M
24 Q3-125.97M
24 Q2-130.95M
24 Q1-132.4M
EBITDA (USD) · TTM
-200M-150M-100M-50M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI EBITDA (USD) · TTM by quarter
PeriodEBITDA (USD) · TTM
26 Q2-175.9M
26 Q1-147.92M
25 Q4-150.45M
25 Q3-80.42M
25 Q2-78.44M
25 Q1-19.64M
24 Q4-38.6M
24 Q3-54.42M
24 Q2-62.19M
24 Q1-121.72M
Cash Flows (USD) · TTM
-150M-100M-50M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Cash Flows (USD) · TTM by quarter
PeriodCash Flows (USD) · TTM
26 Q2-65.35M
26 Q1-59.11M
25 Q4-75.37M
25 Q3-89.3M
25 Q2-102.89M
25 Q1-122.69M
24 Q4-127.63M
24 Q3-120.46M
24 Q2-130.53M
24 Q1-117.73M
EPS (USD) · TTM
-20-15-10-5024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI EPS (USD) · TTM by quarter
PeriodEPS (USD) · TTM
26 Q2-13.07
26 Q1-15.07
25 Q4-16.6
25 Q3-14.58
25 Q2-14.61
25 Q1-13.26
24 Q4-15.34
24 Q3-17.14
24 Q2-17.81
24 Q1-15.13
Expenses (USD) · TTM
-100M0100M200M300MR&DSG&ACapex24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Expenses (USD) · TTM by quarter
PeriodExpenses (USD) · TTM
26 Q2223.92M
26 Q1229.32M
25 Q4230.82M
25 Q3240.82M
25 Q2247.44M
25 Q1255.53M
24 Q4258.64M
24 Q3268.19M
24 Q2270.78M
24 Q1267.39M
Shares Outstanding · TTM
-30M-20M-10M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Shares Outstanding · TTM by quarter
PeriodShares Outstanding · TTM
26 Q2-11.64M
26 Q1-13.5M
25 Q4-14.05M
25 Q3-14.01M
25 Q2-15.39M
25 Q1-17.02M
24 Q4-18.43M
24 Q3-19.74M
24 Q2-20.64M
24 Q1-21.29M
Employee Count
02004006002016201720182019202020212022202320242025
KPTI Employee Count by quarter
PeriodEmployee Count
2025228
2024279
2023325
2022385
2021442
2020432
2019347
2018332
2017154
2016108
Free Cash Flow Yield
-400%-300%-200%-100%0%med -153.77%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
KPTI Free Cash Flow Yield by quarter
PeriodFree Cash Flow Yield
Sep 26-140.26%
Sep 26-126.15%
Aug 26-120.76%
Aug 26-115.21%
Aug 26-111.79%
Aug 26-126.66%
Jul 26-139.86%
Jul 26-36.24%
Jul 26-28.24%
Jul 26-25.97%
Jul 26-27.97%
Jun 26-26.3%
Jun 26-29.77%
Jun 26-28.27%
Jun 26-29.57%
May 26-29.51%
May 26-32.91%
May 26-35.01%
May 26-129.38%
May 26-127.46%
Apr 26-129.08%
Apr 26-129.83%
Apr 26-139.73%
Apr 26-189.79%
Mar 26-203.99%
Mar 26-146.51%
Mar 26-142.4%
Mar 26-127.46%
Feb 26-118.8%
Feb 26-115.6%
Feb 26-130.29%
Feb 26-164.55%
Jan 26-157.99%
Jan 26-156.31%
Jan 26-163.25%
Jan 26-118.67%
Jan 26-143.27%
Dec 25-138.45%
Dec 25-148.43%
Dec 25-148.21%
Dec 25-179.15%
Nov 25-183.29%
Nov 25-174.59%
Nov 25-181.35%
Nov 25-199.63%
Oct 25-205.8%
Oct 25-188.27%
Oct 25-201.29%
Oct 25-217.02%
Oct 25-187.09%
Sep 25-182.23%
Sep 25-220.63%
Sep 25-185.06%
Sep 25-180.85%
Aug 25-167.88%
Aug 25-189.47%
Aug 25-201.63%
Aug 25-367.65%
Aug 25-368.59%
Jul 25-333%
Jul 25-376.25%
Jul 25-318.36%
Jul 25-329.97%
Jun 25-329.97%
Jun 25-330.72%
Jun 25-329.97%
Jun 25-322.62%
May 25-344.89%
May 25-315.59%
May 25-272.28%
May 25-253.05%
May 25-206.63%
Apr 25-270.61%
Apr 25-307.24%
Apr 25-354.5%
Apr 25-393.99%
Mar 25-365.58%
Mar 25-236.89%
Mar 25-225.31%
Mar 25-220.73%
Feb 25-191.3%
Feb 25-169.36%
Feb 25-156.25%
Feb 25-152.62%
Jan 25-154.91%
Jan 25-137.65%
Jan 25-146%
Jan 25-134.08%
Jan 25-123.53%
Dec 24-137.39%
Dec 24-151.66%
Dec 24-137.65%
Dec 24-125.46%
Nov 24-113.99%
Nov 24-113.99%
Nov 24-118.37%
Nov 24-109.91%
Nov 24-119.4%
Oct 24-130.36%
Oct 24-123.97%
Price to Sales
00.511.52med 0.4Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
KPTI Price to Sales by quarter
PeriodPrice to Sales
Sep 260.32
Sep 260.35
Aug 260.37
Aug 260.39
Aug 260.4
Aug 260.31
Jul 260.28
Jul 261.08
Jul 261.39
Jul 261.51
Jul 261.4
Jun 261.49
Jun 261.31
Jun 261.38
Jun 261.32
May 261.33
May 261.19
May 261.12
May 260.4
May 260.4
Apr 260.4
Apr 260.4
Apr 260.37
Apr 260.27
Mar 260.25
Mar 260.35
Mar 260.36
Mar 260.4
Feb 260.43
Feb 260.45
Feb 260.4
Feb 260.38
Jan 260.4
Jan 260.4
Jan 260.38
Jan 260.53
Jan 260.44
Dec 250.45
Dec 250.42
Dec 250.42
Dec 250.35
Nov 250.34
Nov 250.36
Nov 250.35
Nov 250.31
Oct 250.36
Oct 250.4
Oct 250.37
Oct 250.35
Oct 250.4
Sep 250.41
Sep 250.34
Sep 250.41
Sep 250.41
Aug 250.45
Aug 250.4
Aug 250.37
Aug 250.23
Aug 250.23
Jul 250.26
Jul 250.23
Jul 250.27
Jul 250.26
Jun 250.26
Jun 250.26
Jun 250.26
Jun 250.27
May 250.25
May 250.27
May 250.32
May 250.35
May 250.43
Apr 250.32
Apr 250.29
Apr 250.25
Apr 250.22
Mar 250.24
Mar 250.37
Mar 250.39
Mar 250.4
Feb 250.46
Feb 250.52
Feb 250.52
Feb 250.53
Jan 250.52
Jan 250.59
Jan 250.56
Jan 250.61
Jan 250.66
Dec 240.59
Dec 240.54
Dec 240.59
Dec 240.65
Nov 240.71
Nov 240.71
Nov 240.69
Nov 240.74
Nov 240.75
Oct 240.69
Oct 240.72
Price to Book
010203040med 13.15Aug 19Nov 19Mar 20Jun 20Oct 20Jan 21Apr 21
KPTI Price to Book by quarter
PeriodPrice to Book
Apr 2113.61
Apr 2113.68
Apr 2114.15
Apr 2114.6
Apr 2115.8
Mar 2115.01
Mar 2117.58
Mar 2117.94
Mar 2116.95
Feb 2120.14
Feb 2113.23
Feb 2113.33
Feb 2114.17
Jan 2113.34
Jan 2113.22
Jan 2113.09
Jan 2115.4
Dec 2013.56
Dec 2013.97
Dec 2014.43
Dec 2013.45
Dec 2014.27
Nov 2013.26
Nov 2013.67
Nov 2013.45
Nov 2012.4
Oct 208.36
Oct 208.88
Oct 208.9
Oct 208.36
Oct 208.02
Sep 208.37
Sep 209.2
Sep 208.01
Sep 208.58
Aug 208.34
Aug 208.01
Aug 208.27
Aug 208.58
Jul 206.52
Jul 207.29
Jul 207.7
Jul 207.79
Jul 208.01
Jun 207.49
Jun 207.73
Jun 206.79
Jun 207.21
May 207.52
May 208.4
May 207.75
May 207.7
May 2024.81
Apr 2032.29
Apr 2030.07
Apr 2026.33
Apr 2022.85
Mar 2025.11
Mar 2022.97
Mar 2023.75
Mar 2032.09
Feb 2020.95
Feb 2016.67
Feb 2015.93
Feb 2017.89
Jan 2016.73
Jan 2017.09
Jan 2017.65
Jan 2019.04
Jan 2018.88
Dec 1919.94
Dec 1919.01
Dec 1917.35
Dec 1916.87
Nov 1918.15
Nov 1916.85
Nov 1916.16
Nov 1915.26
Nov 199.26
Oct 198.26
Oct 197.9
Oct 197.53
Oct 197.75
Sep 197.25
Sep 197.92
Sep 198.14
Sep 197.07
Aug 196.38
Aug 196.42
Aug 196.69
Aug 196.54
Aug 194.15
Jul 194.35
Jul 194.16
Jul 194.02
Jul 194.42
Jun 193.01
Jun 193.22
Jun 192.87
Jun 192.85
Karyopharm Therapeutics Inc.
KPTI
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News: KPTI

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

prnewswire.com · 1 Sep 2026

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

NEWTON, Mass., Sept. 1, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted an aggregate of 1,850 restricted stock units (RSUs) to two newly-hired employees.

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

gurufocus.com · 31 Aug 2026

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIOÂ (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

prnewswire.com · 31 Aug 2026

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

– sNDA Submitted under the Accelerated Approval Pathway; Priority Review Requested – NEWTON, Mass., Aug. 31, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that it has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) seeking Accelerated Approval for XPOVIO® (selinexor) in combination with ruxolitinib for patients with myelofibrosis.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

prnewswire.com · 27 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 27, 2026 /PRNewswire/ -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. ("Karyopharm" or the "Company") (NASDAQ: KPTI).  Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

globenewswire.com · 25 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 25, 2026 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. (“Karyopharm” or the “Company”) (NASDAQ: KPTI).   Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext. 7980.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

prnewswire.com · 20 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 20, 2026 /PRNewswire/ -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. ("Karyopharm" or the "Company") (NASDAQ: KPTI).  Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

globenewswire.com · 18 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 18, 2026 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. (“Karyopharm” or the “Company”) (NASDAQ: KPTI).   Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext. 7980.

Karyopharm Therapeutics Inc. (KPTI) Q2 2026 Earnings Call Transcript

seekingalpha.com · 13 Aug 2026

Karyopharm Therapeutics Inc. (KPTI) Q2 2026 Earnings Call Transcript

Karyopharm Therapeutics Inc. (KPTI) Q2 2026 Earnings Call Transcript

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