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Karyopharm Therapeutics Inc.

$1.61 -$5.58 (-77.61%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$1.62
Day Range
$1.24$1.61
Year Range
$1.24$10.99
Market Cap
36.49M
AVG Volume
1.17M
Trailing/Forward PE
-0.07/-
PEG ratio
0
Dividend Yield
-
Next Earnings Date
2026-11-02
Primary Exchange
NASDAQUS
Revenue (USD)
020M40M60M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Revenue (USD) by quarter
PeriodRevenue (USD)
26 Q233.43M
26 Q135.07M
25 Q434.08M
25 Q344.04M
25 Q237.93M
25 Q130.02M
24 Q430.54M
24 Q338.78M
24 Q242.79M
24 Q133.13M
Net Income (USD)
-150M-100M-50M050M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Net Income (USD) by quarter
PeriodNet Income (USD)
26 Q2-67.02M
26 Q1-22.39M
25 Q4-102.2M
25 Q3-33.13M
25 Q2-37.25M
25 Q1-23.46M
24 Q4-30.78M
24 Q3-32.07M
24 Q223.79M
24 Q1-37.36M
Operating Income (USD)
-40M-30M-20M-10M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Operating Income (USD) by quarter
PeriodOperating Income (USD)
26 Q2-22.53M
26 Q1-26.76M
25 Q4-17.84M
25 Q3-15.22M
25 Q2-24.39M
25 Q1-33.26M
24 Q4-31.28M
24 Q3-26.28M
24 Q2-28.12M
24 Q1-33.76M
EBITDA (USD)
-100M-50M050M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI EBITDA (USD) by quarter
PeriodEBITDA (USD)
26 Q2-53.88M
26 Q1-9.83M
25 Q4-89.63M
25 Q3-22.56M
25 Q2-25.91M
25 Q1-12.35M
24 Q4-19.6M
24 Q3-20.58M
24 Q232.9M
24 Q1-31.32M
Cash Flows (USD)
-60M-40M-20M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Cash Flows (USD) by quarter
PeriodCash Flows (USD)
26 Q2-24.93M
26 Q1-22.73M
25 Q4-11.83M
25 Q3-5.86M
25 Q2-18.7M
25 Q1-38.98M
24 Q4-25.76M
24 Q3-19.45M
24 Q2-38.5M
24 Q1-43.92M
EPS (USD)
-6-4-2024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI EPS (USD) by quarter
PeriodEPS (USD)
26 Q2-2.32
26 Q1-1.24
25 Q4-5.69
25 Q3-3.82
25 Q2-4.32
25 Q1-2.77
24 Q4-3.67
24 Q3-3.85
24 Q2-2.97
24 Q1-4.85
Expenses (USD)
-20M020M40M60M80MR&DSG&ACapex24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Expenses (USD) by quarter
PeriodExpenses (USD)
26 Q255.86M
26 Q160.47M
25 Q450.44M
25 Q357.15M
25 Q261.27M
25 Q161.97M
24 Q460.44M
24 Q363.77M
24 Q269.35M
24 Q165.08M
Cash & Debt (USD)
0100M200M300MCashLong Term DebtShort Term Debt24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Cash & Debt (USD) by quarter
PeriodCash & Debt (USD)
26 Q265.11M
26 Q190.85M
25 Q463.74M
25 Q345.88M
25 Q251.7M
25 Q169.94M
24 Q4108.71M
24 Q3133.53M
24 Q2152.12M
24 Q1148.58M
Debt ratios
-6-4-2024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Debt ratios by quarter
PeriodDebt ratios
26 Q2-0.86
26 Q1-0.95
25 Q4-1.13
25 Q3-1.87
25 Q2-1.77
25 Q1-5.95
24 Q4-2.22
24 Q3-1.12
24 Q2-0.7
24 Q1-0.23
Margins
0%25%50%75%100%24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Margins by quarter
PeriodMargins
26 Q296.75%
26 Q196.13%
25 Q495.65%
25 Q395.2%
25 Q297.23%
25 Q195.67%
24 Q495.64%
24 Q396.65%
24 Q296.36%
24 Q193.97%
Return on Capital
-20%0%20%40%24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Return on Capital by quarter
PeriodReturn on Capital
26 Q220.3%
26 Q18.43%
25 Q434.89%
25 Q312.3%
25 Q215.59%
25 Q111.4%
24 Q416.55%
24 Q320.09%
24 Q2-18.01%
24 Q122.11%
Shares Outstanding
010M20M30M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Shares Outstanding by quarter
PeriodShares Outstanding
26 Q228.94M
26 Q122.01M
25 Q46.74M
25 Q38.67M
25 Q28.62M
25 Q18.47M
24 Q48.39M
24 Q38.33M
24 Q28.07M
24 Q17.7M
Book Value Per Share (USD)
-60-40-20024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Book Value Per Share (USD) by quarter
PeriodBook Value Per Share (USD)
26 Q2-11.41
26 Q1-12.07
25 Q4-43.45
25 Q3-31.06
25 Q2-27.72
25 Q1-24.31
24 Q4-22.17
24 Q3-19.16
24 Q2-16.38
24 Q1-21.95
Total Assets (USD)
0100M200M300M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
KPTI Total Assets (USD) by quarter
PeriodTotal Assets (USD)
26 Q2111.32M
26 Q1131.42M
25 Q4108.42M
25 Q396.23M
25 Q2104.88M
25 Q1127.71M
24 Q4164.42M
24 Q3189.48M
24 Q2213.98M
24 Q1204.46M
Employee Count
02004006002016201720182019202020212022202320242025
KPTI Employee Count by quarter
PeriodEmployee Count
2025228
2024279
2023325
2022385
2021442
2020432
2019347
2018332
2017154
2016108
Free Cash Flow Yield
-400%-300%-200%-100%0%med -153.77%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
KPTI Free Cash Flow Yield by quarter
PeriodFree Cash Flow Yield
Sep 26-140.26%
Sep 26-126.15%
Aug 26-120.76%
Aug 26-115.21%
Aug 26-111.79%
Aug 26-126.66%
Jul 26-139.86%
Jul 26-36.24%
Jul 26-28.24%
Jul 26-25.97%
Jul 26-27.97%
Jun 26-26.3%
Jun 26-29.77%
Jun 26-28.27%
Jun 26-29.57%
May 26-29.51%
May 26-32.91%
May 26-35.01%
May 26-129.38%
May 26-127.46%
Apr 26-129.08%
Apr 26-129.83%
Apr 26-139.73%
Apr 26-189.79%
Mar 26-203.99%
Mar 26-146.51%
Mar 26-142.4%
Mar 26-127.46%
Feb 26-118.8%
Feb 26-115.6%
Feb 26-130.29%
Feb 26-164.55%
Jan 26-157.99%
Jan 26-156.31%
Jan 26-163.25%
Jan 26-118.67%
Jan 26-143.27%
Dec 25-138.45%
Dec 25-148.43%
Dec 25-148.21%
Dec 25-179.15%
Nov 25-183.29%
Nov 25-174.59%
Nov 25-181.35%
Nov 25-199.63%
Oct 25-205.8%
Oct 25-188.27%
Oct 25-201.29%
Oct 25-217.02%
Oct 25-187.09%
Sep 25-182.23%
Sep 25-220.63%
Sep 25-185.06%
Sep 25-180.85%
Aug 25-167.88%
Aug 25-189.47%
Aug 25-201.63%
Aug 25-367.65%
Aug 25-368.59%
Jul 25-333%
Jul 25-376.25%
Jul 25-318.36%
Jul 25-329.97%
Jun 25-329.97%
Jun 25-330.72%
Jun 25-329.97%
Jun 25-322.62%
May 25-344.89%
May 25-315.59%
May 25-272.28%
May 25-253.05%
May 25-206.63%
Apr 25-270.61%
Apr 25-307.24%
Apr 25-354.5%
Apr 25-393.99%
Mar 25-365.58%
Mar 25-236.89%
Mar 25-225.31%
Mar 25-220.73%
Feb 25-191.3%
Feb 25-169.36%
Feb 25-156.25%
Feb 25-152.62%
Jan 25-154.91%
Jan 25-137.65%
Jan 25-146%
Jan 25-134.08%
Jan 25-123.53%
Dec 24-137.39%
Dec 24-151.66%
Dec 24-137.65%
Dec 24-125.46%
Nov 24-113.99%
Nov 24-113.99%
Nov 24-118.37%
Nov 24-109.91%
Nov 24-119.4%
Oct 24-130.36%
Oct 24-123.97%
Price to Sales
00.511.52med 0.4Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
KPTI Price to Sales by quarter
PeriodPrice to Sales
Sep 260.32
Sep 260.35
Aug 260.37
Aug 260.39
Aug 260.4
Aug 260.31
Jul 260.28
Jul 261.08
Jul 261.39
Jul 261.51
Jul 261.4
Jun 261.49
Jun 261.31
Jun 261.38
Jun 261.32
May 261.33
May 261.19
May 261.12
May 260.4
May 260.4
Apr 260.4
Apr 260.4
Apr 260.37
Apr 260.27
Mar 260.25
Mar 260.35
Mar 260.36
Mar 260.4
Feb 260.43
Feb 260.45
Feb 260.4
Feb 260.38
Jan 260.4
Jan 260.4
Jan 260.38
Jan 260.53
Jan 260.44
Dec 250.45
Dec 250.42
Dec 250.42
Dec 250.35
Nov 250.34
Nov 250.36
Nov 250.35
Nov 250.31
Oct 250.36
Oct 250.4
Oct 250.37
Oct 250.35
Oct 250.4
Sep 250.41
Sep 250.34
Sep 250.41
Sep 250.41
Aug 250.45
Aug 250.4
Aug 250.37
Aug 250.23
Aug 250.23
Jul 250.26
Jul 250.23
Jul 250.27
Jul 250.26
Jun 250.26
Jun 250.26
Jun 250.26
Jun 250.27
May 250.25
May 250.27
May 250.32
May 250.35
May 250.43
Apr 250.32
Apr 250.29
Apr 250.25
Apr 250.22
Mar 250.24
Mar 250.37
Mar 250.39
Mar 250.4
Feb 250.46
Feb 250.52
Feb 250.52
Feb 250.53
Jan 250.52
Jan 250.59
Jan 250.56
Jan 250.61
Jan 250.66
Dec 240.59
Dec 240.54
Dec 240.59
Dec 240.65
Nov 240.71
Nov 240.71
Nov 240.69
Nov 240.74
Nov 240.75
Oct 240.69
Oct 240.72
Price to Book
010203040med 13.15Aug 19Nov 19Mar 20Jun 20Oct 20Jan 21Apr 21
KPTI Price to Book by quarter
PeriodPrice to Book
Apr 2113.61
Apr 2113.68
Apr 2114.15
Apr 2114.6
Apr 2115.8
Mar 2115.01
Mar 2117.58
Mar 2117.94
Mar 2116.95
Feb 2120.14
Feb 2113.23
Feb 2113.33
Feb 2114.17
Jan 2113.34
Jan 2113.22
Jan 2113.09
Jan 2115.4
Dec 2013.56
Dec 2013.97
Dec 2014.43
Dec 2013.45
Dec 2014.27
Nov 2013.26
Nov 2013.67
Nov 2013.45
Nov 2012.4
Oct 208.36
Oct 208.88
Oct 208.9
Oct 208.36
Oct 208.02
Sep 208.37
Sep 209.2
Sep 208.01
Sep 208.58
Aug 208.34
Aug 208.01
Aug 208.27
Aug 208.58
Jul 206.52
Jul 207.29
Jul 207.7
Jul 207.79
Jul 208.01
Jun 207.49
Jun 207.73
Jun 206.79
Jun 207.21
May 207.52
May 208.4
May 207.75
May 207.7
May 2024.81
Apr 2032.29
Apr 2030.07
Apr 2026.33
Apr 2022.85
Mar 2025.11
Mar 2022.97
Mar 2023.75
Mar 2032.09
Feb 2020.95
Feb 2016.67
Feb 2015.93
Feb 2017.89
Jan 2016.73
Jan 2017.09
Jan 2017.65
Jan 2019.04
Jan 2018.88
Dec 1919.94
Dec 1919.01
Dec 1917.35
Dec 1916.87
Nov 1918.15
Nov 1916.85
Nov 1916.16
Nov 1915.26
Nov 199.26
Oct 198.26
Oct 197.9
Oct 197.53
Oct 197.75
Sep 197.25
Sep 197.92
Sep 198.14
Sep 197.07
Aug 196.38
Aug 196.42
Aug 196.69
Aug 196.54
Aug 194.15
Jul 194.35
Jul 194.16
Jul 194.02
Jul 194.42
Jun 193.01
Jun 193.22
Jun 192.87
Jun 192.85
Karyopharm Therapeutics Inc.
KPTI
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News: KPTI

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

prnewswire.com · 1 Sep 2026

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

NEWTON, Mass., Sept. 1, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted an aggregate of 1,850 restricted stock units (RSUs) to two newly-hired employees.

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

gurufocus.com · 31 Aug 2026

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIOÂ (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

prnewswire.com · 31 Aug 2026

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

– sNDA Submitted under the Accelerated Approval Pathway; Priority Review Requested – NEWTON, Mass., Aug. 31, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that it has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) seeking Accelerated Approval for XPOVIO® (selinexor) in combination with ruxolitinib for patients with myelofibrosis.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

prnewswire.com · 27 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 27, 2026 /PRNewswire/ -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. ("Karyopharm" or the "Company") (NASDAQ: KPTI).  Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

globenewswire.com · 25 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 25, 2026 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. (“Karyopharm” or the “Company”) (NASDAQ: KPTI).   Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext. 7980.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

prnewswire.com · 20 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 20, 2026 /PRNewswire/ -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. ("Karyopharm" or the "Company") (NASDAQ: KPTI).  Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

globenewswire.com · 18 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 18, 2026 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. (“Karyopharm” or the “Company”) (NASDAQ: KPTI).   Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext. 7980.

Karyopharm Therapeutics Inc. (KPTI) Q2 2026 Earnings Call Transcript

seekingalpha.com · 13 Aug 2026

Karyopharm Therapeutics Inc. (KPTI) Q2 2026 Earnings Call Transcript

Karyopharm Therapeutics Inc. (KPTI) Q2 2026 Earnings Call Transcript

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