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Karyopharm Therapeutics Inc.

$1.57 -$5.62 (-78.09%)
NASDAQ · 14 Sep 2026 17:05 UTC
Previous Close
$1.61
Day Range
$1.55$1.62
Year Range
$1.24$10.99
Market Cap
35.69M
AVG Volume
1.17M
Trailing/Forward PE
-0.07/-
PEG ratio
0
Dividend Yield
-
Next Earnings Date
2026-11-02
Primary Exchange
NASDAQUS
Revenue (USD)
0100M200M300M2016201720182019202020212022202320242025
KPTI Revenue (USD) by year
PeriodRevenue (USD)
2025146.07M
2024145.24M
2023146.03M
2022157.07M
2021209.82M
2020108.08M
201940.89M
201830.34M
20171.6M
2016154K
Net Income (USD)
-200M-150M-100M-50M02016201720182019202020212022202320242025
KPTI Net Income (USD) by year
PeriodNet Income (USD)
2025-196.04M
2024-76.42M
2023-143.1M
2022-165.29M
2021-124.09M
2020-196.27M
2019-199.59M
2018-178.41M
2017-128.98M
2016-109.58M
Operating Income (USD)
-200M-150M-100M-50M02016201720182019202020212022202320242025
KPTI Operating Income (USD) by year
PeriodOperating Income (USD)
2025-90.71M
2024-119.44M
2023-129.54M
2022-142.2M
2021-98.27M
2020-171.85M
2019-189.28M
2018-179.88M
2017-130.54M
2016-110.73M
EBITDA (USD)
-200M-150M-100M-50M02016201720182019202020212022202320242025
KPTI EBITDA (USD) by year
PeriodEBITDA (USD)
2025-150.45M
2024-38.6M
2023-118.42M
2022-139.31M
2021-96.98M
2020-167.85M
2019-182.68M
2018-175.15M
2017-129.82M
2016-109.65M
Cash Flows (USD)
-200M-150M-100M-50M02016201720182019202020212022202320242025
KPTI Cash Flows (USD) by year
PeriodCash Flows (USD)
2025-75.37M
2024-127.63M
2023-92.72M
2022-149.59M
2021-107.33M
2020-160.38M
2019-191.03M
2018-161.48M
2017-73.78M
2016-84.46M
EPS (USD)
-60-40-2002016201720182019202020212022202320242025
KPTI EPS (USD) by year
PeriodEPS (USD)
2025-16.6
2024-15.34
2023-14.79
2022-2.03
2021-1.71
2020-32.76
2019-48.41
2018-46.91
2017-42
2016-2.93
Expenses (USD)
0100M200M300M400MR&DSG&ACapex2016201720182019202020212022202320242025
KPTI Expenses (USD) by year
PeriodExpenses (USD)
2025230.82M
2024258.64M
2023270.55M
2022294.1M
2021304.9M
2020277.38M
2019227.97M
2018212.58M
2017132.21M
2016110.96M
Cash & Debt (USD)
0100M200M300M400MCashLong Term DebtShort Term Debt2016201720182019202020212022202320242025
KPTI Cash & Debt (USD) by year
PeriodCash & Debt (USD)
202563.74M
2024108.71M
2023191.44M
2022277.97M
2021228.62M
2020249.24M
2019261.96M
2018328.2M
2017146.47M
2016129.55M
Debt ratios
-0.5-0.2500.250.520182019202020212022202320242025
KPTI Debt ratios by year
PeriodDebt ratios
2025-0.38
2024-0.22
20230.03
20220.17
20210.08
20200.18
20190.23
20180.42
Margins
-60000%-40000%-20000%0%20000%2016201720182019202020212022202320242025
KPTI Margins by year
PeriodMargins
202595.93%
202495.74%
202396.56%
202296.68%
202198.38%
202097.5%
2019-63.59%
2018-431.95%
2017-6583.68%
2016-56353.25%
Return on Capital
-500%0%500%1000%2016201720182019202020212022202320242025
KPTI Return on Capital by year
PeriodReturn on Capital
202566.92%
202441.08%
2023105.06%
2022992.38%
2021155.75%
2020-388.31%
2019-400.99%
2018-97.4%
2017-99.63%
2016-67.54%
Shares Outstanding
02.5M5M7.5M10M2016201720182019202020212022202320242025
KPTI Shares Outstanding by year
PeriodShares Outstanding
20256.74M
20248.39M
20237.65M
20226M
20215.04M
20204.92M
20194.26M
20184.05M
20173.24M
20162.76M
Book Value Per Share (USD)
-500501002016201720182019202020212022202320242025
KPTI Book Value Per Share (USD) by year
PeriodBook Value Per Share (USD)
2025-43.45
2024-22.17
2023-17.8
2022-2.78
2021-15.79
202010.28
201911.68
201845.22
201739.92
201658.82
Total Assets (USD)
0100M200M300M400M2016201720182019202020212022202320242025
KPTI Total Assets (USD) by year
PeriodTotal Assets (USD)
2025108.42M
2024164.42M
2023240.44M
2022358.17M
2021305.31M
2020313.05M
2019294.96M
2018341.19M
2017180.29M
2016180.38M
Employee Count
02004006002016201720182019202020212022202320242025
KPTI Employee Count by year
PeriodEmployee Count
2025228
2024279
2023325
2022385
2021442
2020432
2019347
2018332
2017154
2016108
Free Cash Flow Yield
-400%-300%-200%-100%0%med -153.77%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
KPTI Free Cash Flow Yield by year
PeriodFree Cash Flow Yield
Sep 26-140.26%
Sep 26-126.15%
Aug 26-120.76%
Aug 26-115.21%
Aug 26-111.79%
Aug 26-126.66%
Jul 26-139.86%
Jul 26-36.24%
Jul 26-28.24%
Jul 26-25.97%
Jul 26-27.97%
Jun 26-26.3%
Jun 26-29.77%
Jun 26-28.27%
Jun 26-29.57%
May 26-29.51%
May 26-32.91%
May 26-35.01%
May 26-129.38%
May 26-127.46%
Apr 26-129.08%
Apr 26-129.83%
Apr 26-139.73%
Apr 26-189.79%
Mar 26-203.99%
Mar 26-146.51%
Mar 26-142.4%
Mar 26-127.46%
Feb 26-118.8%
Feb 26-115.6%
Feb 26-130.29%
Feb 26-164.55%
Jan 26-157.99%
Jan 26-156.31%
Jan 26-163.25%
Jan 26-118.67%
Jan 26-143.27%
Dec 25-138.45%
Dec 25-148.43%
Dec 25-148.21%
Dec 25-179.15%
Nov 25-183.29%
Nov 25-174.59%
Nov 25-181.35%
Nov 25-199.63%
Oct 25-205.8%
Oct 25-188.27%
Oct 25-201.29%
Oct 25-217.02%
Oct 25-187.09%
Sep 25-182.23%
Sep 25-220.63%
Sep 25-185.06%
Sep 25-180.85%
Aug 25-167.88%
Aug 25-189.47%
Aug 25-201.63%
Aug 25-367.65%
Aug 25-368.59%
Jul 25-333%
Jul 25-376.25%
Jul 25-318.36%
Jul 25-329.97%
Jun 25-329.97%
Jun 25-330.72%
Jun 25-329.97%
Jun 25-322.62%
May 25-344.89%
May 25-315.59%
May 25-272.28%
May 25-253.05%
May 25-206.63%
Apr 25-270.61%
Apr 25-307.24%
Apr 25-354.5%
Apr 25-393.99%
Mar 25-365.58%
Mar 25-236.89%
Mar 25-225.31%
Mar 25-220.73%
Feb 25-191.3%
Feb 25-169.36%
Feb 25-156.25%
Feb 25-152.62%
Jan 25-154.91%
Jan 25-137.65%
Jan 25-146%
Jan 25-134.08%
Jan 25-123.53%
Dec 24-137.39%
Dec 24-151.66%
Dec 24-137.65%
Dec 24-125.46%
Nov 24-113.99%
Nov 24-113.99%
Nov 24-118.37%
Nov 24-109.91%
Nov 24-119.4%
Oct 24-130.36%
Oct 24-123.97%
Price to Sales
00.511.52med 0.4Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
KPTI Price to Sales by year
PeriodPrice to Sales
Sep 260.32
Sep 260.35
Aug 260.37
Aug 260.39
Aug 260.4
Aug 260.31
Jul 260.28
Jul 261.08
Jul 261.39
Jul 261.51
Jul 261.4
Jun 261.49
Jun 261.31
Jun 261.38
Jun 261.32
May 261.33
May 261.19
May 261.12
May 260.4
May 260.4
Apr 260.4
Apr 260.4
Apr 260.37
Apr 260.27
Mar 260.25
Mar 260.35
Mar 260.36
Mar 260.4
Feb 260.43
Feb 260.45
Feb 260.4
Feb 260.38
Jan 260.4
Jan 260.4
Jan 260.38
Jan 260.53
Jan 260.44
Dec 250.45
Dec 250.42
Dec 250.42
Dec 250.35
Nov 250.34
Nov 250.36
Nov 250.35
Nov 250.31
Oct 250.36
Oct 250.4
Oct 250.37
Oct 250.35
Oct 250.4
Sep 250.41
Sep 250.34
Sep 250.41
Sep 250.41
Aug 250.45
Aug 250.4
Aug 250.37
Aug 250.23
Aug 250.23
Jul 250.26
Jul 250.23
Jul 250.27
Jul 250.26
Jun 250.26
Jun 250.26
Jun 250.26
Jun 250.27
May 250.25
May 250.27
May 250.32
May 250.35
May 250.43
Apr 250.32
Apr 250.29
Apr 250.25
Apr 250.22
Mar 250.24
Mar 250.37
Mar 250.39
Mar 250.4
Feb 250.46
Feb 250.52
Feb 250.52
Feb 250.53
Jan 250.52
Jan 250.59
Jan 250.56
Jan 250.61
Jan 250.66
Dec 240.59
Dec 240.54
Dec 240.59
Dec 240.65
Nov 240.71
Nov 240.71
Nov 240.69
Nov 240.74
Nov 240.75
Oct 240.69
Oct 240.72
Price to Book
010203040med 13.15Aug 19Nov 19Mar 20Jun 20Oct 20Jan 21Apr 21
KPTI Price to Book by year
PeriodPrice to Book
Apr 2113.61
Apr 2113.68
Apr 2114.15
Apr 2114.6
Apr 2115.8
Mar 2115.01
Mar 2117.58
Mar 2117.94
Mar 2116.95
Feb 2120.14
Feb 2113.23
Feb 2113.33
Feb 2114.17
Jan 2113.34
Jan 2113.22
Jan 2113.09
Jan 2115.4
Dec 2013.56
Dec 2013.97
Dec 2014.43
Dec 2013.45
Dec 2014.27
Nov 2013.26
Nov 2013.67
Nov 2013.45
Nov 2012.4
Oct 208.36
Oct 208.88
Oct 208.9
Oct 208.36
Oct 208.02
Sep 208.37
Sep 209.2
Sep 208.01
Sep 208.58
Aug 208.34
Aug 208.01
Aug 208.27
Aug 208.58
Jul 206.52
Jul 207.29
Jul 207.7
Jul 207.79
Jul 208.01
Jun 207.49
Jun 207.73
Jun 206.79
Jun 207.21
May 207.52
May 208.4
May 207.75
May 207.7
May 2024.81
Apr 2032.29
Apr 2030.07
Apr 2026.33
Apr 2022.85
Mar 2025.11
Mar 2022.97
Mar 2023.75
Mar 2032.09
Feb 2020.95
Feb 2016.67
Feb 2015.93
Feb 2017.89
Jan 2016.73
Jan 2017.09
Jan 2017.65
Jan 2019.04
Jan 2018.88
Dec 1919.94
Dec 1919.01
Dec 1917.35
Dec 1916.87
Nov 1918.15
Nov 1916.85
Nov 1916.16
Nov 1915.26
Nov 199.26
Oct 198.26
Oct 197.9
Oct 197.53
Oct 197.75
Sep 197.25
Sep 197.92
Sep 198.14
Sep 197.07
Aug 196.38
Aug 196.42
Aug 196.69
Aug 196.54
Aug 194.15
Jul 194.35
Jul 194.16
Jul 194.02
Jul 194.42
Jun 193.01
Jun 193.22
Jun 192.87
Jun 192.85
Karyopharm Therapeutics Inc.
KPTI
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News: KPTI

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

prnewswire.com · 1 Sep 2026

Karyopharm Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

NEWTON, Mass., Sept. 1, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted an aggregate of 1,850 restricted stock units (RSUs) to two newly-hired employees.

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

gurufocus.com · 31 Aug 2026

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIOÂ (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

prnewswire.com · 31 Aug 2026

Karyopharm Submits Supplemental New Drug Application to the FDA for XPOVIO® (selinexor) Plus Ruxolitinib for Patients with Myelofibrosis

– sNDA Submitted under the Accelerated Approval Pathway; Priority Review Requested – NEWTON, Mass., Aug. 31, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that it has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) seeking Accelerated Approval for XPOVIO® (selinexor) in combination with ruxolitinib for patients with myelofibrosis.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

prnewswire.com · 27 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 27, 2026 /PRNewswire/ -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. ("Karyopharm" or the "Company") (NASDAQ: KPTI).  Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

globenewswire.com · 25 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 25, 2026 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. (“Karyopharm” or the “Company”) (NASDAQ: KPTI).   Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext. 7980.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

prnewswire.com · 20 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 20, 2026 /PRNewswire/ -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. ("Karyopharm" or the "Company") (NASDAQ: KPTI).  Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext.

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

globenewswire.com · 18 Aug 2026

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Karyopharm Therapeutics Inc. - KPTI

NEW YORK, Aug. 18, 2026 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Karyopharm Therapeutics Inc. (“Karyopharm” or the “Company”) (NASDAQ: KPTI).   Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext. 7980.

Karyopharm Therapeutics Inc. (KPTI) Q2 2026 Earnings Call Transcript

seekingalpha.com · 13 Aug 2026

Karyopharm Therapeutics Inc. (KPTI) Q2 2026 Earnings Call Transcript

Karyopharm Therapeutics Inc. (KPTI) Q2 2026 Earnings Call Transcript

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