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Spyre Therapeutics, Inc.

$90.6 +$60.02 (+196.27%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$88.71
Day Range
$87.91$91.41
Year Range
$14.51$110.17
Market Cap
7.87B
AVG Volume
1.23M
Trailing/Forward PE
-46.46/-
PEG ratio
-1.46
Dividend Yield
-
Next Earnings Date
2026-11-03
Primary Exchange
NASDAQUS
Revenue (USD) · TTM
025M50M75M100M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SYRE Revenue (USD) · TTM by quarter
PeriodRevenue (USD) · TTM
26 Q290.49M
26 Q190.49M
25 Q490.49M
25 Q30
25 Q20
25 Q10
24 Q40
24 Q30
24 Q20
24 Q1688K
Net Income (USD) · TTM
-400M-300M-200M-100M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SYRE Net Income (USD) · TTM by quarter
PeriodNet Income (USD) · TTM
26 Q2-178.92M
26 Q1-179.44M
25 Q4-155.2M
25 Q3-148.97M
25 Q2-206.81M
25 Q1-208.93M
24 Q4-208.02M
24 Q3-214.9M
24 Q2-185.98M
24 Q1-364.23M
Operating Income (USD) · TTM
-300M-200M-100M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SYRE Operating Income (USD) · TTM by quarter
PeriodOperating Income (USD) · TTM
26 Q2-201.34M
26 Q1-201.64M
25 Q4-209.56M
25 Q3-213.64M
25 Q2-212.15M
25 Q1-214.36M
24 Q4-208.57M
24 Q3-193.23M
24 Q2-156.17M
24 Q1-271.27M
EBITDA (USD) · TTM
-300M-200M-100M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SYRE EBITDA (USD) · TTM by quarter
PeriodEBITDA (USD) · TTM
26 Q2-185.55M
26 Q1-201.29M
25 Q4-170.44M
25 Q3-164.2M
25 Q2-222.03M
25 Q1-208.93M
24 Q4-207.97M
24 Q3-199.43M
24 Q2-163.66M
24 Q1-153.17M
Cash Flows (USD) · TTM
-300M-200M-100M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SYRE Cash Flows (USD) · TTM by quarter
PeriodCash Flows (USD) · TTM
26 Q2-208.94M
26 Q1-185.63M
25 Q4-169.25M
25 Q3-161.87M
25 Q2-154.18M
25 Q1-169.86M
24 Q4-157.41M
24 Q3-151.25M
24 Q2-156.42M
24 Q1-110.82M
EPS (USD) · TTM
-80-60-40-20024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SYRE EPS (USD) · TTM by quarter
PeriodEPS (USD) · TTM
26 Q2-1.95
26 Q1-2.19
25 Q4-1.58
25 Q3-1.03
25 Q2-2.24
25 Q1-2.5
24 Q4-3.57
24 Q3-6.33
24 Q2-14.31
24 Q1-70.24
Expenses (USD) · TTM
0100M200M300MR&DSG&ACapex24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SYRE Expenses (USD) · TTM by quarter
PeriodExpenses (USD) · TTM
26 Q2271.34M
26 Q1241.64M
25 Q4219.56M
25 Q3223.64M
25 Q2222.15M
25 Q1214.36M
24 Q4208.57M
24 Q3195.07M
24 Q2172.92M
24 Q1158.22M
Shares Outstanding (USD) · TTM
-60M-40M-20M020MBuybacks (Repurchases)Stock-Based Compensation24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SYRE Shares Outstanding (USD) · TTM by quarter
PeriodShares Outstanding (USD) · TTM
26 Q2-45.7M
26 Q1-41.56M
25 Q4-37.5M
25 Q3-36.9M
25 Q2-40.44M
25 Q1-39.74M
24 Q4-44.83M
24 Q3-52.89M
24 Q2-44.57M
24 Q1-37.8M
Employee Count
0501001502016201720182019202020212022202320242025
SYRE Employee Count by quarter
PeriodEmployee Count
2025102
202465
202330
202269
2021101
202090
201976
201861
201743
201630
Free Cash Flow Yield
-30%-20%-10%0%med -10.92%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
SYRE Free Cash Flow Yield by quarter
PeriodFree Cash Flow Yield
Sep 26-2.72%
Sep 26-2.77%
Aug 26-2.73%
Aug 26-2.32%
Aug 26-2.38%
Aug 26-2.35%
Jul 26-2.4%
Jul 26-2.31%
Jul 26-2.36%
Jul 26-2.42%
Jul 26-2.73%
Jun 26-2.69%
Jun 26-2.68%
Jun 26-2.93%
Jun 26-3.21%
May 26-3.22%
May 26-3.19%
May 26-3.15%
May 26-3.15%
May 26-3.25%
Apr 26-3.24%
Apr 26-3.09%
Apr 26-4.39%
Apr 26-4.74%
Mar 26-4.76%
Mar 26-5.46%
Mar 26-5.65%
Mar 26-5.61%
Feb 26-5.24%
Feb 26-5.22%
Feb 26-7.31%
Feb 26-7.63%
Jan 26-8.38%
Jan 26-8.37%
Jan 26-8.06%
Jan 26-8.75%
Jan 26-8.76%
Dec 25-8.13%
Dec 25-8.02%
Dec 25-7.97%
Dec 25-8.01%
Nov 25-8.93%
Nov 25-11.04%
Nov 25-11.4%
Nov 25-11.9%
Oct 25-10.38%
Oct 25-10.87%
Oct 25-11.3%
Oct 25-13.27%
Oct 25-15.99%
Sep 25-15.64%
Sep 25-17.07%
Sep 25-16.23%
Sep 25-14.94%
Aug 25-15.4%
Aug 25-14.62%
Aug 25-14.99%
Aug 25-16.76%
Aug 25-17.33%
Jul 25-15.84%
Jul 25-17.3%
Jul 25-17.96%
Jul 25-17.88%
Jun 25-18.52%
Jun 25-18.78%
Jun 25-16.3%
Jun 25-16.61%
May 25-18.45%
May 25-18.78%
May 25-18.57%
May 25-19.99%
May 25-22.15%
Apr 25-23.69%
Apr 25-26.42%
Apr 25-27.39%
Apr 25-26.17%
Mar 25-18.66%
Mar 25-18.42%
Mar 25-18.55%
Mar 25-17.17%
Feb 25-16.99%
Feb 25-13.96%
Feb 25-12.97%
Feb 25-13.12%
Jan 25-12.93%
Jan 25-13.76%
Jan 25-14.41%
Jan 25-13.23%
Jan 25-12.21%
Dec 24-12.56%
Dec 24-12.46%
Dec 24-12.32%
Dec 24-10.98%
Nov 24-10.45%
Nov 24-10.73%
Nov 24-11.82%
Nov 24-8.72%
Nov 24-10.16%
Oct 24-9.92%
Oct 24-10.54%
Price to Sales
0100020003000med 65.09Jun 23Sep 23Jan 24Apr 24Aug 24May 26Sep 26
SYRE Price to Sales by quarter
PeriodPrice to Sales
Sep 2684.83
Sep 2683.31
Aug 2684.6
Aug 2699.71
Aug 2697.03
Aug 2698.23
Jul 2685.35
Jul 2688.65
Jul 2687
Jul 2684.84
Jul 2675.19
Jun 2676.29
Jun 2676.68
Jun 2670.13
Jun 2663.93
May 2663.8
May 2664.28
May 2665.03
May 2665.14
May 2657.6
Apr 2657.81
Apr 2660.58
Apr 2642.56
Apr 2639.48
Mar 2639.26
Mar 2634.23
Mar 2633.1
Mar 2633.32
Feb 2635.69
Feb 2635.85
Aug 241389.92
Jul 241670.14
Jul 241565.59
Jul 241575.14
Jul 241352.77
Jun 241247.69
Jun 241279
Jun 241672.26
Jun 241786.89
May 241854.82
May 241750.27
May 242006.07
May 241959.9
May 24876.52
Apr 24822.14
Apr 24793.97
Apr 24918.41
Apr 24886.32
Mar 24929.19
Mar 241009.3
Mar 241111.46
Mar 24929.19
Mar 24732.48
Feb 2496.06
Feb 2494.59
Feb 2497.57
Feb 24104.86
Jan 24112.03
Jan 2498.26
Jan 2487.18
Jan 2490.6
Dec 2387.67
Dec 2374.02
Dec 2363.14
Dec 2379.89
Dec 2379.77
Nov 2334.37
Nov 2331.91
Nov 2329.54
Nov 2335.21
Oct 2333.18
Oct 2341.25
Oct 2340.41
Oct 2336.58
Sep 2338.13
Sep 2336.92
Sep 2343.27
Sep 2343.58
Sep 2345.14
Aug 2342.33
Aug 2339.65
Aug 2340.46
Aug 2338.84
Jul 2346.61
Jul 2348
Jul 2345.25
Jul 2338.84
Jun 2336.51
Jun 2332.36
Jun 2311.33
Jun 2310.84
Jun 2310.36
May 233.79
May 234.1
May 234.3
May 234.49
Apr 234.74
Apr 234.77
Apr 234.21
Apr 237.27
Price to Book
051015med 3.77Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
SYRE Price to Book by quarter
PeriodPrice to Book
Sep 266.97
Sep 266.85
Aug 266.95
Aug 268.19
Aug 267.97
Aug 268.07
Jul 2611.51
Jul 2611.96
Jul 2611.74
Jul 2611.44
Jul 2610.14
Jun 2610.29
Jun 2610.34
Jun 269.46
Jun 268.62
May 268.61
May 268.67
May 268.77
May 268.79
May 267.29
Apr 267.31
Apr 267.66
Apr 265.38
Apr 265
Mar 264.97
Mar 264.33
Mar 264.19
Mar 264.22
Feb 264.52
Feb 264.54
Feb 264.86
Feb 264.66
Jan 264.25
Jan 264.25
Jan 264.41
Jan 264.06
Jan 264.06
Dec 254.37
Dec 254.43
Dec 254.46
Dec 254.44
Nov 253.98
Nov 253.22
Nov 253.12
Nov 252.99
Oct 253.26
Oct 253.11
Oct 252.99
Oct 252.55
Oct 252.12
Sep 252.16
Sep 251.98
Sep 252.08
Sep 252.26
Aug 252.2
Aug 252.31
Aug 252.26
Aug 252.02
Aug 252.03
Jul 252.22
Jul 252.03
Jul 251.96
Jul 251.97
Jun 251.9
Jun 251.87
Jun 252.16
Jun 252.12
May 251.91
May 251.87
May 251.9
May 251.76
May 251.37
Apr 251.28
Apr 251.15
Apr 251.11
Apr 251.16
Mar 251.63
Mar 251.65
Mar 251.64
Mar 251.77
Feb 251.79
Feb 253.31
Feb 253.56
Feb 253.52
Jan 253.57
Jan 253.36
Jan 253.21
Jan 253.49
Jan 253.78
Dec 243.68
Dec 243.71
Dec 243.75
Dec 244.21
Nov 244.42
Nov 244.31
Nov 243.53
Nov 244.79
Nov 244.11
Oct 244.21
Oct 243.97
Spyre Therapeutics, Inc.
SYRE
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News: SYRE

Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript

seekingalpha.com · 9 Sep 2026

Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript

Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript

Spyre's Anti-IL-23 Antibody Meets Goal in Ulcerative Colitis Study

zacks.com · 9 Sep 2026

Spyre's Anti-IL-23 Antibody Meets Goal in Ulcerative Colitis Study

SYRE's SPY003 posts positive phase II UC data, strengthening Spyre's multi-mechanism IBD strategy.

Spyre Announces Potential Best-in-Class SPY003 (anti-IL-23) Part A Induction Results from SKYLINE Trial, Completing Proof-of-Concept for All Three Components of its IBD Combinations

globenewswire.com · 8 Sep 2026

Spyre Announces Potential Best-in-Class SPY003 (anti-IL-23) Part A Induction Results from SKYLINE Trial, Completing Proof-of-Concept for All Three Components of its IBD Combinations

SPY003 met its primary endpoint with a statistically significant reduction of 10.0 points (p

Spyre Therapeutics Announces Grants of Inducement Awards

globenewswire.com · 4 Sep 2026

Spyre Therapeutics Announces Grants of Inducement Awards

WALTHAM, Mass., Sept. 04, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that Spyre's independent Compensation Committee of the Board of Directors approved the grant of stock options to purchase 2,106 shares of common stock of Spyre and 745 restricted stock units (“RSUs”) to one non-executive employee as an equity inducement award under the Spyre Therapeutics, Inc. 2018 Equity Inducement Plan, as amended (the “2018 Plan”). The stock options and RSUs were approved on September 1, 2026 and were material to the employee's acceptance of employment with Spyre, in accordance with Nasdaq Listing Rule 5635(c)(4).

Spyre Therapeutics to Participate in Upcoming September Investor Conferences

globenewswire.com · 3 Sep 2026

Spyre Therapeutics to Participate in Upcoming September Investor Conferences

WALTHAM, Mass., Sept. 03, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that management will participate in the following upcoming investor conferences: Event : Citi 2026 BioPharma Back to School Conference – New York Date: Wednesday, September 9, 2026 Fireside Time: 10:00 am ET Event: Wells Fargo 21st Annual Healthcare Conference – Boston Date: Thursday, September 10, 2026 Fireside Time: 8:00 am ET Event: Stifel 2026 Virtual Immunology and Inflammation Forum Date: Wednesday, September 23, 2026 Fireside Time: 8:30 am ET Members of the Spyre management team will also host one-on-one investor meetings during the conferences.

Spyre Therapeutics (SYRE) Down 16.6% Since Last Earnings Report: Can It Rebound?

zacks.com · 3 Sep 2026

Spyre Therapeutics (SYRE) Down 16.6% Since Last Earnings Report: Can It Rebound?

Spyre Therapeutics (SYRE) reported earnings 30 days ago. What's next for the stock?

SYRE Stock Sinks After Mixed SKYWAY Study Data in Rheumatoid Arthritis

zacks.com · 26 Aug 2026

SYRE Stock Sinks After Mixed SKYWAY Study Data in Rheumatoid Arthritis

Spyre's SPY072 shows activity in RA, but a smaller-than-expected benefit shifts its focus toward broader autoimmune uses and combinations.

Spyre Therapeutics Says Rheumatoid Arthritis Program Misses Internal Benchmark, Stock Tumbles

benzinga.com · 26 Aug 2026

Spyre Therapeutics Says Rheumatoid Arthritis Program Misses Internal Benchmark, Stock Tumbles

Spyre Therapeutics, Inc. (NASDAQ:SYRE) stock is trading lower on Wednesday after the company shared topline findings from the rheumatoid arthritis (RA) segment of its Phase 2 SKYWAY trial for SPY072.

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