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Spyre Therapeutics, Inc.

$90.8 +$60.22 (+196.93%)
NASDAQ · 14 Sep 2026 20:00 UTC
Previous Close
$90.6
Day Range
$89.43$91.4
Year Range
$14.51$110.17
Market Cap
7.89B
AVG Volume
1.23M
Trailing/Forward PE
-46.56/-
PEG ratio
-1.47
Dividend Yield
-
Next Earnings Date
2026-11-03
Primary Exchange
NASDAQUS
Revenue (USD)
025M50M75M100M2016201720182019202020212022202320242025
SYRE Revenue (USD) by year
PeriodRevenue (USD)
202590.49M
20240
2023886K
20222.33M
202118.74M
20200
20190
20183.89M
20175.2M
20164.63M
Net Income (USD)
-400M-300M-200M-100M02016201720182019202020212022202320242025
SYRE Net Income (USD) by year
PeriodNet Income (USD)
2025-155.2M
2024-208.02M
2023-338.79M
2022-83.81M
2021-65.8M
2020-80.89M
2019-78.25M
2018-44.35M
2017-27.24M
2016-21.7M
Operating Income (USD)
-300M-200M-100M02016201720182019202020212022202320242025
SYRE Operating Income (USD) by year
PeriodOperating Income (USD)
2025-209.56M
2024-208.57M
2023-242.3M
2022-84.78M
2021-65.65M
2020-81.48M
2019-80.33M
2018-45.46M
2017-27.68M
2016-21.91M
EBITDA (USD)
-300M-200M-100M02016201720182019202020212022202320242025
SYRE EBITDA (USD) by year
PeriodEBITDA (USD)
2025-170.44M
2024-207.97M
2023-127.25M
2022-82.01M
2021-63.98M
2020-80.48M
2019-79.92M
2018-45.17M
2017-27.43M
2016-21.77M
Cash Flows (USD)
-200M-150M-100M-50M02016201720182019202020212022202320242025
SYRE Cash Flows (USD) by year
PeriodCash Flows (USD)
2025-169.25M
2024-157.41M
2023-99.91M
2022-80.18M
2021-54.29M
2020-80.06M
2019-67.18M
2018-32.62M
2017-25.23M
2016-19.05M
EPS (USD)
-80-60-40-2002016201720182019202020212022202320242025
SYRE EPS (USD) by year
PeriodEPS (USD)
2025-1.58
2024-3.57
2023-73.93
2022-28.09
2021-27.62
2020-41.32
2019-61.43
2018-52.1
2017-45.62
2016-45.02
Expenses (USD)
0100M200M300MR&DSG&ACapex2016201720182019202020212022202320242025
SYRE Expenses (USD) by year
PeriodExpenses (USD)
2025219.56M
2024208.57M
2023128.9M
202285.18M
202184.46M
202085.76M
201981.83M
201849.77M
201733.5M
201626.75M
Cash & Debt (USD)
0200M400M600M800M2016201720182019202020212022202320242025
SYRE Cash & Debt (USD) by year
PeriodCash & Debt (USD)
2025756.53M
2024603.09M
2023339.28M
202255.71M
202193.13M
2020146.27M
201971.95M
201874.51M
201750.3M
201663.5M
Debt ratios
00.511.520182019202020212022202320242025
SYRE Debt ratios by year
PeriodDebt ratios
20251.29
20241.25
20230.96
20220.17
20210.33
20200.6
20190.38
20180.71
Margins
-75%-50%-25%0%25%50%20152016201720182021202220232025
SYRE Margins by year
PeriodMargins
20250%
202338.15%
202215.67%
2021-54.41%
20180%
20170%
20160%
20150%
Return on Capital
-200%-150%-100%-50%0%2016201720182019202020212022202320242025
SYRE Return on Capital by year
PeriodReturn on Capital
2025-21.7%
2024-40.17%
2023-184.11%
2022-166.61%
2021-78.39%
2020-57.85%
2019-130.25%
2018-65.77%
2017-54.11%
2016-34.46%
Shares Outstanding
020M40M60M80M2016201720182019202020212022202320242025
SYRE Shares Outstanding by year
PeriodShares Outstanding
202575.09M
202447.03M
202321.7M
20222.61M
20211.97M
20202.31M
20191.3M
2018996.69K
2017636.01K
2016463.15K
Book Value Per Share (USD)
0501001502016201720182019202020212022202320242025
SYRE Book Value Per Share (USD) by year
PeriodBook Value Per Share (USD)
20259.53
202411.01
20238.48
202219.24
202142.52
202060.47
201946.18
201867.65
201779.15
2016135.95
Total Assets (USD)
0200M400M600M800M2016201720182019202020212022202320242025
SYRE Total Assets (USD) by year
PeriodTotal Assets (USD)
2025777.78M
2024608.48M
2023341.86M
202271.14M
2021109.93M
2020161.62M
201983.18M
201877.74M
201756.08M
201667.06M
Employee Count
0501001502016201720182019202020212022202320242025
SYRE Employee Count by year
PeriodEmployee Count
2025102
202465
202330
202269
2021101
202090
201976
201861
201743
201630
Free Cash Flow Yield
-30%-20%-10%0%med -10.92%Dec 24Apr 25Jul 25Nov 25Feb 26Jun 26Sep 26
SYRE Free Cash Flow Yield by year
PeriodFree Cash Flow Yield
Sep 26-2.72%
Sep 26-2.72%
Sep 26-2.77%
Aug 26-2.73%
Aug 26-2.32%
Aug 26-2.38%
Aug 26-2.35%
Jul 26-2.4%
Jul 26-2.31%
Jul 26-2.36%
Jul 26-2.42%
Jul 26-2.73%
Jun 26-2.69%
Jun 26-2.68%
Jun 26-2.93%
Jun 26-3.21%
May 26-3.22%
May 26-3.19%
May 26-3.15%
May 26-3.15%
May 26-3.25%
Apr 26-3.24%
Apr 26-3.09%
Apr 26-4.39%
Apr 26-4.74%
Mar 26-4.76%
Mar 26-5.46%
Mar 26-5.65%
Mar 26-5.61%
Feb 26-5.24%
Feb 26-5.22%
Feb 26-7.31%
Feb 26-7.63%
Jan 26-8.38%
Jan 26-8.37%
Jan 26-8.06%
Jan 26-8.75%
Jan 26-8.76%
Dec 25-8.13%
Dec 25-8.02%
Dec 25-7.97%
Dec 25-8.01%
Nov 25-8.93%
Nov 25-11.04%
Nov 25-11.4%
Nov 25-11.9%
Oct 25-10.38%
Oct 25-10.87%
Oct 25-11.3%
Oct 25-13.27%
Oct 25-15.99%
Sep 25-15.64%
Sep 25-17.07%
Sep 25-16.23%
Sep 25-14.94%
Aug 25-15.4%
Aug 25-14.62%
Aug 25-14.99%
Aug 25-16.76%
Aug 25-17.33%
Jul 25-15.84%
Jul 25-17.3%
Jul 25-17.96%
Jul 25-17.88%
Jun 25-18.52%
Jun 25-18.78%
Jun 25-16.3%
Jun 25-16.61%
May 25-18.45%
May 25-18.78%
May 25-18.57%
May 25-19.99%
May 25-22.15%
Apr 25-23.69%
Apr 25-26.42%
Apr 25-27.39%
Apr 25-26.17%
Mar 25-18.66%
Mar 25-18.42%
Mar 25-18.55%
Mar 25-17.17%
Feb 25-16.99%
Feb 25-13.96%
Feb 25-12.97%
Feb 25-13.12%
Jan 25-12.93%
Jan 25-13.76%
Jan 25-14.41%
Jan 25-13.23%
Jan 25-12.21%
Dec 24-12.56%
Dec 24-12.46%
Dec 24-12.32%
Dec 24-10.98%
Nov 24-10.45%
Nov 24-10.73%
Nov 24-11.82%
Nov 24-8.72%
Nov 24-10.16%
Oct 24-9.92%
Price to Sales
0100020003000med 67.63Jun 23Sep 23Jan 24Apr 24Feb 26Jun 26Sep 26
SYRE Price to Sales by year
PeriodPrice to Sales
Sep 2685.02
Sep 2684.83
Sep 2683.31
Aug 2684.6
Aug 2699.71
Aug 2697.03
Aug 2698.23
Jul 2685.35
Jul 2688.65
Jul 2687
Jul 2684.84
Jul 2675.19
Jun 2676.29
Jun 2676.68
Jun 2670.13
Jun 2663.93
May 2663.8
May 2664.28
May 2665.03
May 2665.14
May 2657.6
Apr 2657.81
Apr 2660.58
Apr 2642.56
Apr 2639.48
Mar 2639.26
Mar 2634.23
Mar 2633.1
Mar 2633.32
Feb 2635.69
Feb 2635.85
Aug 241389.92
Jul 241670.14
Jul 241565.59
Jul 241575.14
Jul 241352.77
Jun 241247.69
Jun 241279
Jun 241672.26
Jun 241786.89
May 241854.82
May 241750.27
May 242006.07
May 241959.9
May 24876.52
Apr 24822.14
Apr 24793.97
Apr 24918.41
Apr 24886.32
Mar 24929.19
Mar 241009.3
Mar 241111.46
Mar 24929.19
Mar 24732.48
Feb 2496.06
Feb 2494.59
Feb 2497.57
Feb 24104.86
Jan 24112.03
Jan 2498.26
Jan 2487.18
Jan 2490.6
Dec 2387.67
Dec 2374.02
Dec 2363.14
Dec 2379.89
Dec 2379.77
Nov 2334.37
Nov 2331.91
Nov 2329.54
Nov 2335.21
Oct 2333.18
Oct 2341.25
Oct 2340.41
Oct 2336.58
Sep 2338.13
Sep 2336.92
Sep 2343.27
Sep 2343.58
Sep 2345.14
Aug 2342.33
Aug 2339.65
Aug 2340.46
Aug 2338.84
Jul 2346.61
Jul 2348
Jul 2345.25
Jul 2338.84
Jun 2336.51
Jun 2332.36
Jun 2311.33
Jun 2310.84
Jun 2310.36
May 233.79
May 234.1
May 234.3
May 234.49
Apr 234.74
Apr 234.77
Apr 234.21
Price to Book
051015med 3.77Dec 24Apr 25Jul 25Nov 25Feb 26Jun 26Sep 26
SYRE Price to Book by year
PeriodPrice to Book
Sep 266.99
Sep 266.97
Sep 266.85
Aug 266.95
Aug 268.19
Aug 267.97
Aug 268.07
Jul 2611.51
Jul 2611.96
Jul 2611.74
Jul 2611.44
Jul 2610.14
Jun 2610.29
Jun 2610.34
Jun 269.46
Jun 268.62
May 268.61
May 268.67
May 268.77
May 268.79
May 267.29
Apr 267.31
Apr 267.66
Apr 265.38
Apr 265
Mar 264.97
Mar 264.33
Mar 264.19
Mar 264.22
Feb 264.52
Feb 264.54
Feb 264.86
Feb 264.66
Jan 264.25
Jan 264.25
Jan 264.41
Jan 264.06
Jan 264.06
Dec 254.37
Dec 254.43
Dec 254.46
Dec 254.44
Nov 253.98
Nov 253.22
Nov 253.12
Nov 252.99
Oct 253.26
Oct 253.11
Oct 252.99
Oct 252.55
Oct 252.12
Sep 252.16
Sep 251.98
Sep 252.08
Sep 252.26
Aug 252.2
Aug 252.31
Aug 252.26
Aug 252.02
Aug 252.03
Jul 252.22
Jul 252.03
Jul 251.96
Jul 251.97
Jun 251.9
Jun 251.87
Jun 252.16
Jun 252.12
May 251.91
May 251.87
May 251.9
May 251.76
May 251.37
Apr 251.28
Apr 251.15
Apr 251.11
Apr 251.16
Mar 251.63
Mar 251.65
Mar 251.64
Mar 251.77
Feb 251.79
Feb 253.31
Feb 253.56
Feb 253.52
Jan 253.57
Jan 253.36
Jan 253.21
Jan 253.49
Jan 253.78
Dec 243.68
Dec 243.71
Dec 243.75
Dec 244.21
Nov 244.42
Nov 244.31
Nov 243.53
Nov 244.79
Nov 244.11
Oct 244.21
Spyre Therapeutics, Inc.
SYRE
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News: SYRE

11,250 Shares in Spyre Therapeutics, Inc. $SYRE Acquired by VIRGINIA RETIREMENT SYSTEMS ET Al

defenseworld.net · 14 Sep 2026

11,250 Shares in Spyre Therapeutics, Inc. $SYRE Acquired by VIRGINIA RETIREMENT SYSTEMS ET Al

VIRGINIA RETIREMENT SYSTEMS ET Al purchased a new stake in Spyre Therapeutics, Inc. (NASDAQ: SYRE) during the second quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission. The institutional investor purchased 11,250 shares of the company's stock, valued at approximately $999,000. Other hedge funds have

Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript

seekingalpha.com · 9 Sep 2026

Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript

Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript

Spyre's Anti-IL-23 Antibody Meets Goal in Ulcerative Colitis Study

zacks.com · 9 Sep 2026

Spyre's Anti-IL-23 Antibody Meets Goal in Ulcerative Colitis Study

SYRE's SPY003 posts positive phase II UC data, strengthening Spyre's multi-mechanism IBD strategy.

Spyre Announces Potential Best-in-Class SPY003 (anti-IL-23) Part A Induction Results from SKYLINE Trial, Completing Proof-of-Concept for All Three Components of its IBD Combinations

globenewswire.com · 8 Sep 2026

Spyre Announces Potential Best-in-Class SPY003 (anti-IL-23) Part A Induction Results from SKYLINE Trial, Completing Proof-of-Concept for All Three Components of its IBD Combinations

SPY003 met its primary endpoint with a statistically significant reduction of 10.0 points (p

Spyre Therapeutics Announces Grants of Inducement Awards

globenewswire.com · 4 Sep 2026

Spyre Therapeutics Announces Grants of Inducement Awards

WALTHAM, Mass., Sept. 04, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that Spyre's independent Compensation Committee of the Board of Directors approved the grant of stock options to purchase 2,106 shares of common stock of Spyre and 745 restricted stock units (“RSUs”) to one non-executive employee as an equity inducement award under the Spyre Therapeutics, Inc. 2018 Equity Inducement Plan, as amended (the “2018 Plan”). The stock options and RSUs were approved on September 1, 2026 and were material to the employee's acceptance of employment with Spyre, in accordance with Nasdaq Listing Rule 5635(c)(4).

Spyre Therapeutics to Participate in Upcoming September Investor Conferences

globenewswire.com · 3 Sep 2026

Spyre Therapeutics to Participate in Upcoming September Investor Conferences

WALTHAM, Mass., Sept. 03, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that management will participate in the following upcoming investor conferences: Event : Citi 2026 BioPharma Back to School Conference – New York Date: Wednesday, September 9, 2026 Fireside Time: 10:00 am ET Event: Wells Fargo 21st Annual Healthcare Conference – Boston Date: Thursday, September 10, 2026 Fireside Time: 8:00 am ET Event: Stifel 2026 Virtual Immunology and Inflammation Forum Date: Wednesday, September 23, 2026 Fireside Time: 8:30 am ET Members of the Spyre management team will also host one-on-one investor meetings during the conferences.

Spyre Therapeutics (SYRE) Down 16.6% Since Last Earnings Report: Can It Rebound?

zacks.com · 3 Sep 2026

Spyre Therapeutics (SYRE) Down 16.6% Since Last Earnings Report: Can It Rebound?

Spyre Therapeutics (SYRE) reported earnings 30 days ago. What's next for the stock?

SYRE Stock Sinks After Mixed SKYWAY Study Data in Rheumatoid Arthritis

zacks.com · 26 Aug 2026

SYRE Stock Sinks After Mixed SKYWAY Study Data in Rheumatoid Arthritis

Spyre's SPY072 shows activity in RA, but a smaller-than-expected benefit shifts its focus toward broader autoimmune uses and combinations.

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