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Ionis Pharmaceuticals, Inc.

$54.21 -$25.46 (-31.96%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$55.65
Day Range
$54.18$56.15
Year Range
$50.01$86.74
Market Cap
9.01B
AVG Volume
2.72M
Trailing/Forward PE
-15.67/-
PEG ratio
0.34
Dividend Yield
-
Next Earnings Date
2026-11-04
Primary Exchange
NASDAQUS
Revenue (USD)
0500M1B1.5B2016201720182019202020212022202320242025
IONS Revenue (USD) by year
PeriodRevenue (USD)
2025943.38M
2024705.14M
2023787.65M
2022587.37M
2021810.46M
2020729.26M
20191.12B
2018599.68M
2017518.69M
2016346.62M
Net Income (USD)
-600M-400M-200M0200M400M2016201720182019202020212022202320242025
IONS Net Income (USD) by year
PeriodNet Income (USD)
2025-380.99M
2024-453.9M
2023-366.29M
2022-269.72M
2021-28.6M
2020-430M
2019294.15M
2018273.74M
20176.01M
2016-86.56M
Operating Income (USD)
-500M-250M0250M500M2016201720182019202020212022202320242025
IONS Operating Income (USD) by year
PeriodOperating Income (USD)
2025-382.23M
2024-475.08M
2023-353.73M
2022-410.19M
2021-30.18M
2020-172.08M
2019365.88M
2018-61.37M
201735.55M
2016-46.32M
EBITDA (USD)
-2B02B4B6B2016201720182019202020212022202320242025
IONS EBITDA (USD) by year
PeriodEBITDA (USD)
20254.53B
2024-352.23M
2023-234.47M
2022-233.06M
2021-8.99M
2020-108.59M
2019411.53M
2018-18.84M
201740.85M
2016-35.8M
Cash Flows (USD)
-1B-500M0500M1B2016201720182019202020212022202320242025
IONS Cash Flows (USD) by year
PeriodCash Flows (USD)
2025-320.03M
2024-561.49M
2023-334.73M
2022-294.47M
202112.9M
2020-5.16M
2019309.44M
2018585.24M
2017136.29M
2016-123.63M
EPS (USD)
-4-20242016201720182019202020212022202320242025
IONS EPS (USD) by year
PeriodEPS (USD)
2025-2.46
2024-3.04
2023-2.55
2022-1.9
2021-0.38
2020-3.23
20192.07
20181.86
2017-0.01
2016-0.72
Expenses (USD)
0500M1B1.5BR&DSG&ACapex2016201720182019202020212022202320242025
IONS Expenses (USD) by year
PeriodExpenses (USD)
20251.36B
20241.23B
20231.16B
20221B
2021831.68M
2020930.61M
2019788.71M
2018676.88M
2017520.99M
2016404.46M
Cash & Debt (USD)
01B2B3BCashLong Term DebtShort Term Debt2016201720182019202020212022202320242025
IONS Cash & Debt (USD) by year
PeriodCash & Debt (USD)
20252.68B
20242.3B
20232.33B
20221.99B
20212.11B
20201.89B
20192.5B
20182.08B
20171.02B
201687.1M
Debt ratios
-20-10010203020182019202020212022202320242025
IONS Debt ratios by year
PeriodDebt ratios
2025-0.02
20241.06
20231.5
2022-10.14
2021-3.14
2020-3.03
2019-4.34
201826.36
Margins
0%25%50%75%100%2016201720182019202020212022202320242025
IONS Margins by year
PeriodMargins
202598.31%
202498.41%
202398.84%
202297.6%
202198.66%
202098.36%
201999.61%
201880.78%
201727.77%
20160.66%
Return on Capital
-100%-50%0%50%2016201720182019202020212022202320242025
IONS Return on Capital by year
PeriodReturn on Capital
2025-77.9%
2024-77.15%
2023-94.72%
2022-47.08%
2021-3.71%
2020-57.85%
201917.46%
201823.06%
20171.65%
2016-86.93%
Shares Outstanding
050M100M150M200M2016201720182019202020212022202320242025
IONS Shares Outstanding by year
PeriodShares Outstanding
2025162M
2024158M
2023144M
2022142M
2021141M
2020139.96M
2019141M
2018137.7M
2017124.82M
2016121.34M
Book Value Per Share (USD)
0510152016201720182019202020212022202320242025
IONS Book Value Per Share (USD) by year
PeriodBook Value Per Share (USD)
20253.02
20243.72
20232.69
20224.03
20215.47
20205.31
201911.95
20188.62
20172.93
20160.82
Total Assets (USD)
01B2B3B4B2016201720182019202020212022202320242025
IONS Total Assets (USD) by year
PeriodTotal Assets (USD)
20253.52B
20243B
20232.99B
20222.53B
20212.61B
20202.39B
20193.23B
20182.67B
20171.32B
2016912.47M
Employee Count
05001K1.5K2016201720182019202020212022202320242025
IONS Employee Count by year
PeriodEmployee Count
20251.4K
20241.07K
2023927
2022796
2021660
2020757
2019817
2018737
2017547
2016435
PE Ratio
02505007501000med 45.3Sep 19Dec 19Apr 20Jul 20Nov 20Feb 21Feb 23
IONS PE Ratio by year
PeriodPE Ratio
Feb 23748.43
Feb 23756.19
Feb 23793.42
Jan 23775.96
Jan 23790.31
Jan 23772.67
Jan 23785.66
Dec 22732.34
Dec 22739.9
Dec 22749.6
Dec 22727.1
Dec 22781.78
Nov 22805.82
Nov 22835.49
Nov 22838.59
Feb 2185.12
Feb 2184.19
Feb 2188.81
Jan 2188.63
Jan 2191.11
Jan 2190.42
Jan 2190.06
Dec 2083.42
Dec 2088.06
Dec 2080.16
Dec 2067.59
Dec 2075.58
Nov 2075.44
Nov 2072.51
Nov 2076.09
Nov 2071.75
Oct 2045.02
Oct 2045.4
Oct 2045.2
Oct 2044.05
Oct 2043.78
Sep 2046.7
Sep 2049.28
Sep 2049.84
Sep 2053.33
Aug 2050.62
Aug 2050.51
Aug 2050.61
Aug 2053.9
Jul 2047.19
Jul 2048.33
Jul 2050.95
Jul 2050.9
Jul 2049.84
Jun 2049.26
Jun 2048.33
Jun 2047.85
Jun 2047.19
May 2046.08
May 2044.65
May 2043.51
May 2044.6
May 2026.52
Apr 2027.87
Apr 2026.4
Apr 2025.41
Apr 2023.25
Mar 2023.68
Mar 2020.89
Mar 2023.21
Mar 2025.83
Feb 2016.61
Feb 2019.78
Feb 2019.66
Feb 2019.78
Jan 2019.07
Jan 2019.43
Jan 2019.66
Jan 2020.5
Jan 2019.76
Dec 1919.88
Dec 1920.16
Dec 1920.62
Dec 1921.13
Nov 1920.92
Nov 1920.09
Nov 1919.17
Nov 1918.66
Nov 1919.45
Oct 1918.94
Oct 1919.61
Oct 1922.05
Oct 1920.61
Sep 1920.75
Sep 1922.04
Sep 1923.26
Sep 1921.7
Aug 1922.21
Aug 1923.88
Aug 1924.28
Aug 1924.05
Aug 1924.85
Jul 1924.64
Jul 1926.5
Jul 1925.25
Free Cash Flow Yield
-15%-10%-5%0%med -6.73%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
IONS Free Cash Flow Yield by year
PeriodFree Cash Flow Yield
Sep 26-6.23%
Sep 26-5.82%
Aug 26-5.53%
Aug 26-5.66%
Aug 26-5.9%
Aug 26-5.97%
Jul 26-6.53%
Jul 26-10.42%
Jul 26-10.83%
Jul 26-10.11%
Jul 26-7.2%
Jun 26-7.26%
Jun 26-7.95%
Jun 26-8.04%
Jun 26-7.91%
May 26-7.7%
May 26-7.8%
May 26-7.94%
May 26-7.78%
May 26-7.83%
Apr 26-2.7%
Apr 26-2.61%
Apr 26-2.63%
Apr 26-2.64%
Mar 26-2.74%
Mar 26-2.78%
Mar 26-2.77%
Mar 26-2.67%
Feb 26-2.43%
Feb 26-2.26%
Feb 26-2.34%
Feb 26-2.18%
Jan 26-2.28%
Jan 26-2.34%
Jan 26-2.47%
Jan 26-2.34%
Jan 26-2.36%
Dec 25-2.36%
Dec 25-2.37%
Dec 25-2.33%
Dec 25-2.3%
Nov 25-2.28%
Nov 25-2.47%
Nov 25-2.63%
Nov 25-2.56%
Oct 25-2.53%
Oct 25-2.59%
Oct 25-2.51%
Oct 25-2.62%
Oct 25-2.65%
Sep 25-2.86%
Sep 25-3.01%
Sep 25-2.9%
Sep 25-3%
Aug 25-4.3%
Aug 25-4.3%
Aug 25-4.19%
Aug 25-4.41%
Aug 25-4.26%
Jul 25-8.49%
Jul 25-8.59%
Jul 25-8.59%
Jul 25-8.34%
Jun 25-9.01%
Jun 25-9.58%
Jun 25-10.08%
Jun 25-10.16%
May 25-10.7%
May 25-10.87%
May 25-10.68%
May 25-11.11%
May 25-10.94%
Apr 25-11.97%
Apr 25-12.51%
Apr 25-12.74%
Apr 25-13.12%
Mar 25-11.41%
Mar 25-10.8%
Mar 25-10.78%
Mar 25-10.51%
Feb 25-10.71%
Feb 25-11%
Feb 25-8.37%
Feb 25-8.28%
Jan 25-8.15%
Jan 25-7.48%
Jan 25-8.27%
Jan 25-7.77%
Jan 25-7.47%
Dec 24-7.24%
Dec 24-7.29%
Dec 24-7.1%
Dec 24-6.82%
Nov 24-7.27%
Nov 24-7.64%
Nov 24-7.57%
Nov 24-6.63%
Nov 24-6.62%
Oct 24-6.55%
Oct 24-6.46%
Price to Sales
57.51012.515med 10.03Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
IONS Price to Sales by year
PeriodPrice to Sales
Sep 2610.26
Sep 2611
Aug 2611.56
Aug 2611.31
Aug 2610.84
Aug 2610.71
Jul 269.8
Jul 268.81
Jul 268.48
Jul 269.08
Jul 2612.75
Jun 2612.65
Jun 2611.55
Jun 2611.42
Jun 2611.61
May 2611.92
May 2611.78
May 2611.57
May 2611.8
May 2611.73
Apr 2612.58
Apr 2613
Apr 2612.91
Apr 2612.84
Mar 2612.39
Mar 2612.19
Mar 2612.22
Mar 2612.71
Feb 2613.94
Feb 2613.82
Feb 2613.4
Feb 2614.38
Jan 2613.74
Jan 2613.35
Jan 2612.69
Jan 2613.35
Jan 2613.25
Dec 2513.29
Dec 2513.23
Dec 2513.44
Dec 2513.58
Nov 2513.75
Nov 2512.65
Nov 2511.9
Nov 2512.23
Oct 2512.35
Oct 2511.94
Oct 2512.32
Oct 2511.79
Oct 2511.66
Sep 2510.8
Sep 2510.28
Sep 2510.65
Sep 2510.32
Aug 257.19
Aug 257.2
Aug 257.38
Aug 257.02
Aug 257.25
Jul 259.35
Jul 259.24
Jul 259.24
Jul 259.52
Jun 258.81
Jun 258.28
Jun 257.88
Jun 257.81
May 257.42
May 257.3
May 257.43
May 257.14
May 257.25
Apr 256.65
Apr 256.36
Apr 256.25
Apr 256.07
Mar 256.98
Mar 257.37
Mar 257.39
Mar 257.58
Feb 257.44
Feb 257.24
Feb 255.74
Feb 255.81
Jan 255.9
Jan 256.43
Jan 255.82
Jan 256.19
Jan 256.44
Dec 246.64
Dec 246.59
Dec 246.77
Dec 247.05
Nov 246.61
Nov 246.29
Nov 246.35
Nov 247.25
Nov 246.95
Oct 247.03
Oct 247.12
EV/EBITDA
0100200300400med 30.12Jul 20Oct 20Feb 21Jul 22Feb 23May 26Sep 26
IONS EV/EBITDA by year
PeriodEV/EBITDA
Sep 262.15
Sep 262.3
Aug 262.42
Aug 262.37
Aug 262.27
Aug 262.24
Jul 262.06
Jul 262.06
Jul 261.98
Jul 262.12
Jul 262.97
Jun 262.95
Jun 262.69
Jun 262.66
Jun 262.7
May 262.78
May 262.74
May 262.7
May 262.75
May 262.73
Apr 262.6
Apr 262.69
Apr 262.67
Apr 262.66
Mar 262.56
Mar 262.52
Mar 262.53
Mar 262.63
Feb 262.89
Feb 23152.66
Feb 23154.49
Feb 23163.3
Jan 23159.17
Jan 23162.57
Jan 23158.39
Jan 23161.47
Dec 22148.85
Dec 22150.64
Dec 22152.93
Dec 22147.61
Dec 22160.55
Nov 22166.24
Nov 22173.26
Nov 22174
Aug 22351.79
Jul 22279.91
Jul 22284.67
Jul 22295.36
Jul 22276.28
Jul 22284.32
Jun 22294.83
Jun 22259.6
Jun 22255.18
Jun 22267.45
May 22280.52
May 22296.95
May 22266.84
May 22268.78
Feb 2142.25
Feb 2141.68
Feb 2144.51
Jan 2144.4
Jan 2145.92
Jan 2145.49
Jan 2145.27
Dec 2041.21
Dec 2044.05
Dec 2039.21
Dec 2031.52
Dec 2036.41
Nov 2036.32
Nov 2034.53
Nov 2036.72
Nov 2034.07
Oct 2025.12
Oct 2025.4
Oct 2025.25
Oct 2024.41
Oct 2024.21
Sep 2026.35
Sep 2028.24
Sep 2028.65
Sep 2031.2
Aug 2029.22
Aug 2029.14
Aug 2029.21
Aug 2031.62
Jul 2028.35
Jul 2029.2
Jul 2031.17
Jul 2031.14
Jul 2030.34
Jun 2029.91
Jun 2029.2
Jun 2028.85
Jun 2028.35
May 2027.52
May 2026.45
May 2025.59
May 2026.41
Price/Operating Cashflow
050100150200250med 45.2Aug 20Nov 20Mar 21Apr 22Jul 22Nov 22Feb 23
IONS Price/Operating Cashflow by year
PeriodPrice/Operating Cashflow
Feb 2342.31
Feb 2342.75
Feb 2344.85
Jan 2343.86
Jan 2344.67
Jan 2343.68
Jan 2344.41
Dec 2241.4
Dec 2241.82
Dec 2242.37
Dec 2241.1
Dec 2244.19
Nov 2245.55
Nov 2247.23
Nov 2247.4
Nov 2259.89
Oct 2264.3
Oct 2264.79
Oct 2266.83
Oct 2266.21
Sep 2263.76
Sep 2262.32
Sep 2266.78
Sep 2267.52
Sep 2262.33
Aug 2261.05
Aug 2263.43
Aug 2263.57
Aug 22120.26
Jul 2298.84
Jul 22100.26
Jul 22103.44
Jul 2297.76
Jul 22100.15
Jun 22103.28
Jun 2292.78
Jun 2291.47
Jun 2295.13
May 2299.02
May 22103.91
May 2294.94
May 2295.52
Apr 22168.29
Apr 22191.04
Apr 22187.56
Apr 22183.67
Apr 22178.09
Mar 22167.88
Mar 22161.38
Mar 22147.37
Mar 22147.87
Feb 22145.49
Apr 21166.97
Apr 21166.47
Apr 21159.02
Apr 21165.18
Apr 21175.67
Mar 21167.48
Mar 21211.39
Mar 21206.63
Mar 21205.81
Feb 21204.33
Feb 2137.34
Feb 2136.93
Feb 2138.96
Jan 2138.88
Jan 2139.97
Jan 2139.66
Jan 2139.51
Dec 2036.6
Dec 2038.63
Dec 2035.17
Dec 2029.65
Dec 2033.15
Nov 2033.09
Nov 2031.81
Nov 2033.38
Nov 2031.48
Oct 2030.66
Oct 2030.91
Oct 2030.78
Oct 2030
Oct 2029.81
Sep 2031.8
Sep 2033.56
Sep 2033.94
Sep 2036.31
Aug 2034.47
Aug 2034.39
Aug 2034.47
Aug 2036.71
Jul 2034.83
Jul 2035.67
Jul 2037.61
Jul 2037.57
Jul 2036.78
Jun 2036.36
Jun 2035.67
Jun 2035.32
Jun 2034.83
Price to Book
0102030med 18.05Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
IONS Price to Book by year
PeriodPrice to Book
Sep 2620.39
Sep 2621.85
Aug 2622.97
Aug 2622.47
Aug 2621.53
Aug 2621.28
Jul 2619.47
Jul 2618.97
Jul 2618.25
Jul 2619.54
Jul 2627.44
Jun 2627.24
Jun 2624.87
Jun 2624.59
Jun 2624.99
May 2625.67
May 2625.35
May 2624.9
May 2625.4
May 2625.26
Apr 2624.27
Apr 2625.08
Apr 2624.9
Apr 2624.77
Mar 2623.9
Mar 2623.51
Mar 2623.58
Mar 2624.52
Feb 2626.88
Feb 2621.63
Feb 2620.97
Feb 2622.5
Jan 2621.51
Jan 2620.89
Jan 2619.86
Jan 2620.89
Jan 2620.73
Dec 2520.79
Dec 2520.7
Dec 2521.02
Dec 2521.25
Nov 2521.52
Nov 2519.79
Nov 2518.61
Nov 2519.13
Oct 2519.33
Oct 2517.85
Oct 2518.41
Oct 2517.63
Oct 2517.42
Sep 2516.14
Sep 2515.37
Sep 2515.91
Sep 2515.42
Aug 2510.74
Aug 2510.75
Aug 2511.03
Aug 2510.49
Aug 2510.84
Jul 2514.1
Jul 2513.93
Jul 2513.92
Jul 2514.35
Jun 2513.28
Jun 2512.48
Jun 2511.88
Jun 2511.78
May 2511.18
May 2511
May 2511.2
May 2510.76
May 2510.94
Apr 257.98
Apr 257.63
Apr 257.49
Apr 257.27
Mar 258.37
Mar 258.84
Mar 258.85
Mar 259.08
Feb 258.91
Feb 258.68
Feb 256.96
Feb 257.04
Jan 257.16
Jan 257.79
Jan 257.05
Jan 257.51
Jan 257.81
Dec 248.05
Dec 247.99
Dec 248.21
Dec 248.55
Nov 248.01
Nov 247.63
Nov 247.7
Nov 248.79
Nov 2421.45
Oct 2421.69
Oct 2421.96
Ionis Pharmaceuticals, Inc.
IONS
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News: IONS

Ionis Pharmaceuticals, Inc. (IONS) Presents at Wells Fargo 21st Annual Healthcare Conference Transcript

seekingalpha.com · 10 Sep 2026

Ionis Pharmaceuticals, Inc. (IONS) Presents at Wells Fargo 21st Annual Healthcare Conference Transcript

Ionis Pharmaceuticals, Inc. (IONS) Presents at Wells Fargo 21st Annual Healthcare Conference Transcript

Cathie Wood Is Loading Up on Ionis Pharmaceuticals (IONS) Stock. Here's the Bet She's Making.

fool.com · 9 Sep 2026

Cathie Wood Is Loading Up on Ionis Pharmaceuticals (IONS) Stock. Here's the Bet She's Making.

Cathie Wood has bought and sold the stock a lot, so don't follow her blindly. The company posted a loss in its last quarter, but revenue is growing robustly.

Novartis' Del-desiran Fails Late-Stage DM1 Study, Shares Fall

zacks.com · 9 Sep 2026

Novartis' Del-desiran Fails Late-Stage DM1 Study, Shares Fall

NVS' del-desiran fails the HARBOR study's primary endpoint, adding to recent pipeline setbacks as investors await next steps.

Ionis Pharmaceuticals (NASDAQ:IONS) Shares Gap Down  After Analyst Downgrade

defenseworld.net · 9 Sep 2026

Ionis Pharmaceuticals (NASDAQ:IONS) Shares Gap Down After Analyst Downgrade

Ionis Pharmaceuticals, Inc. (NASDAQ: IONS - Get Free Report) shares gapped down prior to trading on Tuesday after Morgan Stanley lowered their price target on the stock from $110.00 to $104.00. The stock had previously closed at $58.09, but opened at $52.15. Morgan Stanley currently has an overweight rating on the stock. Ionis Pharmaceuticals shares last

Novartis, Ionis Pharmaceuticals And Other Big Stocks Moving Lower In Tuesday's Pre-Market Session

benzinga.com · 8 Sep 2026

Novartis, Ionis Pharmaceuticals And Other Big Stocks Moving Lower In Tuesday's Pre-Market Session

U.S. stock futures were lower this morning, with the Dow futures falling over 400 points on Tuesday.

Novartis Stock Drops as Trial Failures Ripple Across Biotech Partners

benzinga.com · 8 Sep 2026

Novartis Stock Drops as Trial Failures Ripple Across Biotech Partners

On Tuesday, Novartis AG (NYSE:NVS) stock witnessed one of the sharpest single-day declines for the company in recent history.

Novartis Late-Stage Cardiovascular Outcome Study Fails, Stock Down

zacks.com · 7 Sep 2026

Novartis Late-Stage Cardiovascular Outcome Study Fails, Stock Down

Novartis' pelacarsen study failed to cut cardiovascular events, clouding prospects for the drug and highlighting portfolio challenges.

Amgen Shares Fall as Novartis' Pelacarsen Misses Phase III Study Goal

zacks.com · 7 Sep 2026

Amgen Shares Fall as Novartis' Pelacarsen Misses Phase III Study Goal

AMGN shares fall as NVS' pelacarsen setback casts investor concern over whether olpasiran can deliver positive phase III outcome data.

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