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Denali Therapeutics Inc.

$21.09 +$4.82 (+29.63%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$21.4
Day Range
$21.05$21.79
Year Range
$12.58$27.3
Market Cap
3.35B
AVG Volume
1.68M
Trailing/Forward PE
-7.43/-
PEG ratio
-3.09
Dividend Yield
-
Next Earnings Date
2026-11-05
Primary Exchange
NASDAQUS
Revenue (USD) · TTM
0100M200M300M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
DNLI Revenue (USD) · TTM by quarter
PeriodRevenue (USD) · TTM
26 Q23.6M
26 Q10
25 Q40
25 Q30
25 Q20
25 Q10
24 Q40
24 Q30
24 Q21.27M
24 Q1295.39M
Net Income (USD) · TTM
-600M-400M-200M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
DNLI Net Income (USD) · TTM by quarter
PeriodNet Income (USD) · TTM
26 Q2-511.45M
26 Q1-508.02M
25 Q4-512.54M
25 Q3-498.74M
25 Q2-479.03M
25 Q1-453.94M
24 Q4-422.77M
24 Q3-427.49M
24 Q2-419.65M
24 Q1-137.25M
Operating Income (USD) · TTM
-600M-400M-200M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
DNLI Operating Income (USD) · TTM by quarter
PeriodOperating Income (USD) · TTM
26 Q2-542.7M
26 Q1-547.12M
25 Q4-555.34M
25 Q3-547.82M
25 Q2-533.58M
25 Q1-515.21M
24 Q4-487.34M
24 Q3-490.07M
24 Q2-480.68M
24 Q1-193.6M
EBITDA (USD) · TTM
-600M-400M-200M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
DNLI EBITDA (USD) · TTM by quarter
PeriodEBITDA (USD) · TTM
26 Q2-497.29M
26 Q1-493.47M
25 Q4-497.63M
25 Q3-485.03M
25 Q2-466.91M
25 Q1-443.83M
24 Q4-444.16M
24 Q3-449.36M
24 Q2-441.58M
24 Q1-158.82M
Cash Flows (USD) · TTM
-600M-400M-200M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
DNLI Cash Flows (USD) · TTM by quarter
PeriodCash Flows (USD) · TTM
26 Q2-437.46M
26 Q1-419.23M
25 Q4-422.1M
25 Q3-410.85M
25 Q2-367.95M
25 Q1-384.38M
24 Q4-363.61M
24 Q3-375.69M
24 Q2-402.1M
24 Q1-425.11M
EPS (USD) · TTM
-3-2-1024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
DNLI EPS (USD) · TTM by quarter
PeriodEPS (USD) · TTM
26 Q2-2.84
26 Q1-2.88
25 Q4-2.97
25 Q3-2.91
25 Q2-2.8
25 Q1-2.67
24 Q4-2.57
24 Q3-2.76
24 Q2-2.85
24 Q1-0.96
Expenses (USD) · TTM
0200M400M600MR&DSG&ACapex24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
DNLI Expenses (USD) · TTM by quarter
PeriodExpenses (USD) · TTM
26 Q2543.16M
26 Q1548.3M
25 Q4561.98M
25 Q3560.89M
25 Q2551.91M
25 Q1534.05M
24 Q4517.79M
24 Q3517.66M
24 Q2507.72M
24 Q1515.83M
Shares Outstanding (USD) · TTM
-150M-100M-50M0Buybacks (Repurchases)Stock-Based Compensation24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
DNLI Shares Outstanding (USD) · TTM by quarter
PeriodShares Outstanding (USD) · TTM
26 Q2-69.95M
26 Q1-47.04M
25 Q4-49.11M
25 Q3-50.24M
25 Q2-50.24M
25 Q1-75.34M
24 Q4-78.02M
24 Q3-78.93M
24 Q2-106.39M
24 Q1-81.29M
Employee Count
0200400600201720182019202020212022202320242025
DNLI Employee Count by quarter
PeriodEmployee Count
2025503
2024422
2023445
2022427
2021380
2020291
2019261
2018179
2017130
PE Ratio
50100150200250med 122.94Mar 21May 21Jul 21Sep 21Nov 21Dec 21Feb 22
DNLI PE Ratio by quarter
PeriodPE Ratio
Feb 22136.01
Feb 22134.16
Feb 22143.5
Feb 22139.3
Jan 22133.29
Jan 22133.25
Jan 22143.46
Jan 22171.13
Dec 21183.65
Dec 21195.39
Dec 21194.65
Dec 21178.34
Dec 21175.38
Nov 21185.38
Nov 21193.99
Nov 21209.14
Nov 21226.56
Oct 21104.86
Oct 21103.67
Oct 2198.81
Oct 21110.41
Oct 21110.57
Sep 21110.61
Sep 21114.58
Sep 21111.98
Sep 21118.27
Aug 21115.27
Aug 21106.14
Aug 21114.36
Aug 21112.89
Jul 21106.51
Jul 21133.37
Jul 21134.52
Jul 21150.78
Jul 21160.71
Jun 21155.87
Jun 21153.89
Jun 21156.54
Jun 21134.92
May 21132.72
May 21122.94
May 21112.5
May 21113.33
Apr 21102.09
Apr 2195.93
Apr 2191.23
Apr 2188.28
Apr 2194.48
Mar 2193.33
Mar 21104.75
Mar 21109.27
Mar 21103.11
Feb 21121.28
Free Cash Flow Yield
-20%-15%-10%-5%med -12.23%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
DNLI Free Cash Flow Yield by quarter
PeriodFree Cash Flow Yield
Sep 26-11.07%
Sep 26-10.48%
Aug 26-9.73%
Aug 26-9.37%
Aug 26-9.57%
Aug 26-9.41%
Jul 26-9.76%
Jul 26-9.72%
Jul 26-9.64%
Jul 26-8.75%
Jul 26-8.7%
Jun 26-8.78%
Jun 26-9.64%
Jun 26-10.37%
Jun 26-11.51%
May 26-10.68%
May 26-12.05%
May 26-12.06%
May 26-11.45%
May 26-13.15%
Apr 26-12.11%
Apr 26-11.7%
Apr 26-12.51%
Apr 26-11.65%
Mar 26-13.25%
Mar 26-11.93%
Mar 26-11.7%
Mar 26-12.22%
Feb 26-11.36%
Feb 26-11.8%
Feb 26-12.69%
Feb 26-11.3%
Jan 26-10.96%
Jan 26-11.77%
Jan 26-13.25%
Jan 26-13.95%
Jan 26-14.65%
Dec 25-14.12%
Dec 25-14.14%
Dec 25-13.25%
Dec 25-11.94%
Nov 25-12.24%
Nov 25-13.24%
Nov 25-13.66%
Nov 25-15.86%
Oct 25-13.18%
Oct 25-13.45%
Oct 25-12.88%
Oct 25-13.96%
Oct 25-13.92%
Sep 25-15.38%
Sep 25-16.83%
Sep 25-15.12%
Sep 25-13.91%
Aug 25-14.05%
Aug 25-13.85%
Aug 25-14.6%
Aug 25-16.08%
Aug 25-16.7%
Jul 25-16.42%
Jul 25-16.04%
Jul 25-15.46%
Jul 25-15.28%
Jun 25-15.92%
Jun 25-16.16%
Jun 25-15.43%
Jun 25-15.27%
May 25-16.96%
May 25-16.73%
May 25-16.29%
May 25-15.62%
May 25-13%
Apr 25-13.63%
Apr 25-16.78%
Apr 25-16.83%
Apr 25-18.15%
Mar 25-14.46%
Mar 25-14.81%
Mar 25-14.11%
Mar 25-12.81%
Feb 25-12.91%
Feb 25-10.69%
Feb 25-10.37%
Feb 25-9.96%
Jan 25-9.52%
Jan 25-9.98%
Jan 25-10.11%
Jan 25-11.61%
Jan 25-10.43%
Dec 24-10.76%
Dec 24-10.34%
Dec 24-9.65%
Dec 24-8.91%
Nov 24-8.87%
Nov 24-8.98%
Nov 24-8.85%
Nov 24-7.07%
Nov 24-8.8%
Oct 24-9.11%
Oct 24-8.63%
Price to Sales
0200040006000med 11.97Mar 23Jul 23Oct 23Feb 24May 24Aug 24Sep 26
DNLI Price to Sales by quarter
PeriodPrice to Sales
Sep 261096.13
Sep 261157.98
Aug 261247.38
Aug 261295.19
Aug 261268.17
Aug 261290.52
Nov 243604.49
Oct 243484.56
Oct 243676.45
Oct 243731.08
Oct 243815.03
Sep 243921.63
Sep 244118.84
Sep 244100.19
Sep 243364.63
Aug 243256.7
Aug 243300.67
Aug 243067.48
Aug 242983.53
Aug 242914.24
Jul 2412.19
Jul 2410.85
Jul 2411.56
Jul 2410.69
Jun 2411.74
Jun 2411.45
Jun 2410.48
Jun 2410.51
May 249.39
May 249.72
May 2410.37
May 249.26
May 247.17
Apr 246.45
Apr 246.69
Apr 247.64
Apr 248.11
Mar 248.58
Mar 248.21
Mar 248.42
Mar 248.75
Mar 248.72
Feb 246.84
Feb 246.87
Feb 247.29
Feb 246.48
Jan 246.81
Jan 246.9
Jan 247.49
Jan 247.81
Dec 238.67
Dec 238.87
Dec 239.26
Dec 237.42
Dec 237.66
Nov 237.44
Nov 237.58
Nov 236.55
Nov 238.72
Oct 237.27
Oct 237.32
Oct 238.29
Oct 238.35
Sep 238.24
Sep 238.85
Sep 239.41
Sep 239.58
Sep 239.31
Aug 239.19
Aug 239.02
Aug 239.63
Aug 2337.19
Jul 2337.65
Jul 2339.21
Jul 2339.47
Jul 2339.4
Jun 2339.71
Jun 2338.91
Jun 2341.77
Jun 2341.07
Jun 2342.41
May 2340.31
May 2342.49
May 2337.62
May 2332.49
Apr 2330.43
Apr 2330.77
Apr 2330.27
Apr 2329.75
Mar 2328.23
Mar 2328.05
Mar 2328.58
Mar 2328.45
Mar 2334.07
Feb 2328.9
Feb 2334.04
Feb 2332.49
Feb 2335.36
Jan 2335.1
Jan 2332.43
EV/EBITDA
5075100125150175med 86.87Mar 21May 21Jul 21Sep 21Nov 21Dec 21Feb 22
DNLI EV/EBITDA by quarter
PeriodEV/EBITDA
Feb 2284.18
Feb 2282.67
Feb 2290.3
Feb 2286.87
Jan 2281.96
Jan 2281.93
Jan 2290.27
Jan 22112.87
Dec 21123.09
Dec 21132.68
Dec 21132.07
Dec 21118.75
Dec 21116.33
Nov 21124.5
Nov 21131.53
Nov 21143.91
Nov 21158.13
Oct 2176.22
Oct 2175.12
Oct 2170.64
Oct 2181.34
Oct 2181.48
Sep 2181.52
Sep 2185.18
Sep 2182.78
Sep 2188.58
Aug 2185.82
Aug 2177.4
Aug 2184.98
Aug 2183.62
Jul 2180.29
Jul 21106.2
Jul 21107.3
Jul 21122.98
Jul 21132.56
Jun 21127.89
Jun 21125.98
Jun 21128.54
Jun 21107.69
May 21105.57
May 2196.13
May 2186.07
May 2186.87
Apr 2182.27
Apr 2176.12
Apr 2171.43
Apr 2168.48
Apr 2174.66
Mar 2173.52
Mar 2184.92
Mar 2189.44
Mar 2183.28
Feb 21101.43
Price/Operating Cashflow
10152025med 15.6Mar 21May 21Jul 21Sep 21Nov 21Dec 21Feb 22
DNLI Price/Operating Cashflow by quarter
PeriodPrice/Operating Cashflow
Feb 2210.93
Feb 2210.78
Feb 2211.53
Feb 2211.19
Jan 2210.71
Jan 2210.7
Jan 2211.53
Jan 2213.75
Dec 2114.75
Dec 2115.7
Dec 2115.64
Dec 2114.33
Dec 2114.09
Nov 2114.89
Nov 2115.58
Nov 2116.8
Nov 2118.2
Oct 2114.32
Oct 2114.16
Oct 2113.49
Oct 2115.08
Oct 2115.1
Sep 2115.1
Sep 2115.65
Sep 2115.29
Sep 2116.15
Aug 2115.74
Aug 2114.49
Aug 2115.62
Aug 2115.42
Jul 2114.66
Jul 2118.36
Jul 2118.51
Jul 2120.75
Jul 2122.12
Jun 2121.45
Jun 2121.18
Jun 2121.54
Jun 2118.57
May 2118.27
May 2116.92
May 2115.48
May 2115.6
Apr 2117.45
Apr 2116.4
Apr 2115.6
Apr 2115.09
Apr 2116.15
Mar 2115.95
Mar 2117.91
Mar 2118.68
Mar 2117.62
Feb 2120.73
Price to Book
123456med 3.14Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
DNLI Price to Book by quarter
PeriodPrice to Book
Sep 264.73
Sep 265
Aug 265.38
Aug 265.59
Aug 265.47
Aug 265.57
Jul 264.64
Jul 264.66
Jul 264.69
Jul 265.18
Jul 265.21
Jun 265.15
Jun 264.7
Jun 264.37
Jun 263.93
May 264.24
May 263.76
May 263.75
May 263.95
May 263.17
Apr 263.44
Apr 263.56
Apr 263.33
Apr 263.57
Mar 263.14
Mar 263.49
Mar 263.56
Mar 263.41
Feb 263.67
Feb 263.76
Feb 263.49
Feb 263.92
Jan 264.05
Jan 263.77
Jan 263.35
Jan 263.18
Jan 263.03
Dec 253.14
Dec 253.14
Dec 253.35
Dec 253.72
Nov 253.62
Nov 253.35
Nov 253.25
Nov 252.8
Oct 252.72
Oct 252.66
Oct 252.78
Oct 252.57
Oct 252.57
Sep 252.33
Sep 252.13
Sep 252.37
Sep 252.58
Aug 252.55
Aug 252.59
Aug 252.45
Aug 252.13
Aug 252.05
Jul 252.08
Jul 252.14
Jul 252.21
Jul 252.24
Jun 252.15
Jun 252.12
Jun 252.22
Jun 252.24
May 252.02
May 252.05
May 252.1
May 252.19
May 252.27
Apr 252.17
Apr 251.76
Apr 251.76
Apr 251.63
Mar 252.04
Mar 252
Mar 252.1
Mar 252.31
Feb 252.29
Feb 252.66
Feb 252.75
Feb 252.86
Jan 252.99
Jan 252.86
Jan 252.82
Jan 252.45
Jan 252.73
Dec 242.65
Dec 242.76
Dec 242.95
Dec 243.2
Nov 243.21
Nov 243.17
Nov 243.22
Nov 244.03
Nov 243.29
Oct 243.18
Oct 243.36
Denali Therapeutics Inc.
DNLI
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News: DNLI

BlackRock Inc. Takes Position in Denali Therapeutics Inc. $DNLI

defenseworld.net · 26 Aug 2026

BlackRock Inc. Takes Position in Denali Therapeutics Inc. $DNLI

BlackRock Inc. bought a new stake in Denali Therapeutics Inc. (NASDAQ: DNLI) in the undefined quarter, according to its most recent filing with the Securities and Exchange Commission. The institutional investor bought 14,026,413 shares of the company's stock, valued at approximately $360,759,000. BlackRock Inc. owned about 8.84% of Denali Therapeutics at the end

DNLI Stock Gains 33.1% in Three Months: Buy, Sell or Hold the Stock?

zacks.com · 20 Aug 2026

DNLI Stock Gains 33.1% in Three Months: Buy, Sell or Hold the Stock?

Denali's Avlayah launch drives strong uptake and a 33.1% three-month stock gain, but regulatory and pipeline risks remain.

Denali Therapeutics: Bullish On Avlayah And Their Prospects

seekingalpha.com · 19 Aug 2026

Denali Therapeutics: Bullish On Avlayah And Their Prospects

AVLAYAH's approval has helped validate Denali Therapeutics' TransportVehicle platform. They're now moving into their commercial stage as a business. Early payer coverage and Q3 guidance support a credible launch ramp. However, AVLAYAH's US label limits its near-term potential. Zafinofusp alfa and four TV-enabled 2027 readouts provide meaningful pipeline upside beyond AVLAYAH.

Head to Head Comparison: Denali Therapeutics (NASDAQ:DNLI) versus Humacyte (NASDAQ:HUMA)

defenseworld.net · 19 Aug 2026

Head to Head Comparison: Denali Therapeutics (NASDAQ:DNLI) versus Humacyte (NASDAQ:HUMA)

Denali Therapeutics (NASDAQ: DNLI - Get Free Report) and Humacyte (NASDAQ: HUMA - Get Free Report) are both healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their analyst recommendations, dividends, valuation, institutional ownership, earnings, profitability and risk. Analyst Recommendations This is a summary of recent recommendations

Denali Therapeutics: AVLAYAH Converts A Platform Story Into A Commercial One

seekingalpha.com · 13 Aug 2026

Denali Therapeutics: AVLAYAH Converts A Platform Story Into A Commercial One

Denali Therapeutics (DNLI) is transitioning from a neuroscience platform to a commercial biotech with AVLAYAH, its FDA-approved rare-disease therapy. AVLAYAH's Q2 revenue of $3.6M is projected to triple in Q3, reflecting accelerating patient uptake and payer coverage progress. DNLI's TransportVehicle platform underpins a pipeline spanning enzymes, antibodies, and oligonucleotides, targeting both rare and large neurodegenerative markets.

Baillie Gifford Trims Denali Therapeutics (DNLI) Stake in June Reduction

gurufocus.com · 10 Aug 2026

Baillie Gifford Trims Denali Therapeutics (DNLI) Stake in June Reduction

On June 30, 2026, Baillie Gifford (Trades, Portfolio) executed a reduction of 106,249 shares in Denali Therapeutics Inc (NASDAQ: DNLI) at a traded price of $25.7

Denali Therapeutics Inc. $DNLI Shares Acquired by California State Teachers Retirement System

defenseworld.net · 10 Aug 2026

Denali Therapeutics Inc. $DNLI Shares Acquired by California State Teachers Retirement System

California State Teachers Retirement System increased its position in shares of Denali Therapeutics Inc. (NASDAQ: DNLI) by 25.6% during the first quarter, according to the company in its most recent Form 13F filing with the SEC. The fund owned 162,576 shares of the company's stock after acquiring an additional 33,167 shares during the

DNLI Q2 Loss Narrows, Avlayah Sales Drive Strong Launch Momentum

zacks.com · 7 Aug 2026

DNLI Q2 Loss Narrows, Avlayah Sales Drive Strong Launch Momentum

Denali Therapeutics narrows Q2 loss as Avlayah sales top estimates, with strong launch traction and pipeline updates shaping its outlook.

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