AI Analysis

Log in to generate an AI summary for this stock.

Log in to generate a MOAT report for this stock.

Log in to generate an earnings report for this stock.

Log in to generate an operating leverage report for this stock.

Log in to generate a management report for this stock.

Log in to generate a valuation report for this stock.

Denali Therapeutics Inc.

$21.09 +$4.82 (+29.63%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$21.4
Day Range
$21.05$21.79
Year Range
$12.58$27.3
Market Cap
3.35B
AVG Volume
1.68M
Trailing/Forward PE
-7.43/-
PEG ratio
-3.09
Dividend Yield
-
Next Earnings Date
2026-11-05
Primary Exchange
NASDAQUS
Revenue (USD)
0100M200M300M400M2016201720182019202020212022202320242025
DNLI Revenue (USD) by year
PeriodRevenue (USD)
20250
20240
2023330.53M
2022108.46M
202148.66M
2020335.66M
201926.68M
2018129.16M
20170
20160
Net Income (USD)
-600M-400M-200M0200M2016201720182019202020212022202320242025
DNLI Net Income (USD) by year
PeriodNet Income (USD)
2025-512.54M
2024-422.77M
2023-145.22M
2022-325.99M
2021-290.58M
202071.14M
2019-197.61M
2018-36.24M
2017-88.19M
2016-86.65M
Operating Income (USD)
-600M-400M-200M0200M2016201720182019202020212022202320242025
DNLI Operating Income (USD) by year
PeriodOperating Income (USD)
2025-555.34M
2024-487.34M
2023-196.7M
2022-340.74M
2021-295.75M
202062.72M
2019-213.18M
2018-46.37M
2017-90.14M
2016-82.22M
EBITDA (USD)
-600M-400M-200M0200M2016201720182019202020212022202320242025
DNLI EBITDA (USD) by year
PeriodEBITDA (USD)
2025-497.63M
2024-444.16M
2023-128.47M
2022-315.59M
2021-283.74M
202071.25M
2019-205.19M
2018-38.96M
2017-87.06M
2016-80.66M
Cash Flows (USD)
-500M-250M0250M500M2016201720182019202020212022202320242025
DNLI Cash Flows (USD) by year
PeriodCash Flows (USD)
2025-422.1M
2024-363.61M
2023-370.93M
2022-262.55M
2021-219.89M
2020413.06M
2019-169.5M
201846.72M
2017-79.51M
2016-78.49M
EPS (USD)
-15-10-5052016201720182019202020212022202320242025
DNLI EPS (USD) by year
PeriodEPS (USD)
2025-2.97
2024-2.57
2023-1.08
2022-2.58
2021-2.38
20200.26
2019-2.06
2018-0.44
2017-3.69
2016-13.4
Expenses (USD)
0200M400M600MR&DSG&ACapex2016201720182019202020212022202320242025
DNLI Expenses (USD) by year
PeriodExpenses (USD)
2025561.98M
2024517.79M
2023540.17M
2022467.04M
2021352.91M
2020276.04M
2019257.78M
2018178.93M
201793.02M
201693.57M
Cash & Debt (USD)
0500M1B1.5BCashShort Term Debt2016201720182019202020212022202320242025
DNLI Cash & Debt (USD) by year
PeriodCash & Debt (USD)
2025867.88M
2024832.33M
20231.03B
20221.34B
2021865.41M
20201.47B
2019415.36M
2018464.3M
2017406.23M
2016178.33M
Debt ratios
02462019202020212022202320242025
DNLI Debt ratios by year
PeriodDebt ratios
20250.6
20240.67
20231.5
20221.74
20211.75
20205.39
20190.83
Margins
0%50%100%150%201820192020202120222023
DNLI Margins by year
PeriodMargins
2023100%
2022100%
2021100%
2020100%
2019100%
2018100%
Return on Capital
-60%-40%-20%0%20%2016201720182019202020212022202320242025
DNLI Return on Capital by year
PeriodReturn on Capital
2025-50.56%
2024-34.38%
2023-14.09%
2022-31.27%
2021-30.2%
20206.18%
2019-50.04%
2018-6.63%
2017-18.93%
2016-34.05%
Shares Outstanding
050M100M150M200M2016201720182019202020212022202320242025
DNLI Shares Outstanding by year
PeriodShares Outstanding
2025175.46M
2024170.09M
2023138.25M
2022132.88M
2021122.16M
2020120.16M
201995.56M
201894.3M
201730.74M
20169.02M
Book Value Per Share (USD)
01020302016201720182019202020212022202320242025
DNLI Book Value Per Share (USD) by year
PeriodBook Value Per Share (USD)
20255.78
20247.23
20237.46
20227.85
20217.88
20209.57
20194.13
20185.8
201715.15
201628.23
Total Assets (USD)
0500M1B1.5B2B2016201720182019202020212022202320242025
DNLI Total Assets (USD) by year
PeriodTotal Assets (USD)
20251.14B
20241.37B
20231.15B
20221.46B
20211.4B
20201.6B
2019553.23M
2018661.98M
2017486.72M
2016271.07M
Employee Count
0200400600201720182019202020212022202320242025
DNLI Employee Count by year
PeriodEmployee Count
2025503
2024422
2023445
2022427
2021380
2020291
2019261
2018179
2017130
PE Ratio
50100150200250med 122.94Mar 21May 21Jul 21Sep 21Nov 21Dec 21Feb 22
DNLI PE Ratio by year
PeriodPE Ratio
Feb 22136.01
Feb 22134.16
Feb 22143.5
Feb 22139.3
Jan 22133.29
Jan 22133.25
Jan 22143.46
Jan 22171.13
Dec 21183.65
Dec 21195.39
Dec 21194.65
Dec 21178.34
Dec 21175.38
Nov 21185.38
Nov 21193.99
Nov 21209.14
Nov 21226.56
Oct 21104.86
Oct 21103.67
Oct 2198.81
Oct 21110.41
Oct 21110.57
Sep 21110.61
Sep 21114.58
Sep 21111.98
Sep 21118.27
Aug 21115.27
Aug 21106.14
Aug 21114.36
Aug 21112.89
Jul 21106.51
Jul 21133.37
Jul 21134.52
Jul 21150.78
Jul 21160.71
Jun 21155.87
Jun 21153.89
Jun 21156.54
Jun 21134.92
May 21132.72
May 21122.94
May 21112.5
May 21113.33
Apr 21102.09
Apr 2195.93
Apr 2191.23
Apr 2188.28
Apr 2194.48
Mar 2193.33
Mar 21104.75
Mar 21109.27
Mar 21103.11
Feb 21121.28
Free Cash Flow Yield
-20%-15%-10%-5%med -12.23%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
DNLI Free Cash Flow Yield by year
PeriodFree Cash Flow Yield
Sep 26-11.07%
Sep 26-10.48%
Aug 26-9.73%
Aug 26-9.37%
Aug 26-9.57%
Aug 26-9.41%
Jul 26-9.76%
Jul 26-9.72%
Jul 26-9.64%
Jul 26-8.75%
Jul 26-8.7%
Jun 26-8.78%
Jun 26-9.64%
Jun 26-10.37%
Jun 26-11.51%
May 26-10.68%
May 26-12.05%
May 26-12.06%
May 26-11.45%
May 26-13.15%
Apr 26-12.11%
Apr 26-11.7%
Apr 26-12.51%
Apr 26-11.65%
Mar 26-13.25%
Mar 26-11.93%
Mar 26-11.7%
Mar 26-12.22%
Feb 26-11.36%
Feb 26-11.8%
Feb 26-12.69%
Feb 26-11.3%
Jan 26-10.96%
Jan 26-11.77%
Jan 26-13.25%
Jan 26-13.95%
Jan 26-14.65%
Dec 25-14.12%
Dec 25-14.14%
Dec 25-13.25%
Dec 25-11.94%
Nov 25-12.24%
Nov 25-13.24%
Nov 25-13.66%
Nov 25-15.86%
Oct 25-13.18%
Oct 25-13.45%
Oct 25-12.88%
Oct 25-13.96%
Oct 25-13.92%
Sep 25-15.38%
Sep 25-16.83%
Sep 25-15.12%
Sep 25-13.91%
Aug 25-14.05%
Aug 25-13.85%
Aug 25-14.6%
Aug 25-16.08%
Aug 25-16.7%
Jul 25-16.42%
Jul 25-16.04%
Jul 25-15.46%
Jul 25-15.28%
Jun 25-15.92%
Jun 25-16.16%
Jun 25-15.43%
Jun 25-15.27%
May 25-16.96%
May 25-16.73%
May 25-16.29%
May 25-15.62%
May 25-13%
Apr 25-13.63%
Apr 25-16.78%
Apr 25-16.83%
Apr 25-18.15%
Mar 25-14.46%
Mar 25-14.81%
Mar 25-14.11%
Mar 25-12.81%
Feb 25-12.91%
Feb 25-10.69%
Feb 25-10.37%
Feb 25-9.96%
Jan 25-9.52%
Jan 25-9.98%
Jan 25-10.11%
Jan 25-11.61%
Jan 25-10.43%
Dec 24-10.76%
Dec 24-10.34%
Dec 24-9.65%
Dec 24-8.91%
Nov 24-8.87%
Nov 24-8.98%
Nov 24-8.85%
Nov 24-7.07%
Nov 24-8.8%
Oct 24-9.11%
Oct 24-8.63%
Price to Sales
0200040006000med 11.97Mar 23Jul 23Oct 23Feb 24May 24Aug 24Sep 26
DNLI Price to Sales by year
PeriodPrice to Sales
Sep 261096.13
Sep 261157.98
Aug 261247.38
Aug 261295.19
Aug 261268.17
Aug 261290.52
Nov 243604.49
Oct 243484.56
Oct 243676.45
Oct 243731.08
Oct 243815.03
Sep 243921.63
Sep 244118.84
Sep 244100.19
Sep 243364.63
Aug 243256.7
Aug 243300.67
Aug 243067.48
Aug 242983.53
Aug 242914.24
Jul 2412.19
Jul 2410.85
Jul 2411.56
Jul 2410.69
Jun 2411.74
Jun 2411.45
Jun 2410.48
Jun 2410.51
May 249.39
May 249.72
May 2410.37
May 249.26
May 247.17
Apr 246.45
Apr 246.69
Apr 247.64
Apr 248.11
Mar 248.58
Mar 248.21
Mar 248.42
Mar 248.75
Mar 248.72
Feb 246.84
Feb 246.87
Feb 247.29
Feb 246.48
Jan 246.81
Jan 246.9
Jan 247.49
Jan 247.81
Dec 238.67
Dec 238.87
Dec 239.26
Dec 237.42
Dec 237.66
Nov 237.44
Nov 237.58
Nov 236.55
Nov 238.72
Oct 237.27
Oct 237.32
Oct 238.29
Oct 238.35
Sep 238.24
Sep 238.85
Sep 239.41
Sep 239.58
Sep 239.31
Aug 239.19
Aug 239.02
Aug 239.63
Aug 2337.19
Jul 2337.65
Jul 2339.21
Jul 2339.47
Jul 2339.4
Jun 2339.71
Jun 2338.91
Jun 2341.77
Jun 2341.07
Jun 2342.41
May 2340.31
May 2342.49
May 2337.62
May 2332.49
Apr 2330.43
Apr 2330.77
Apr 2330.27
Apr 2329.75
Mar 2328.23
Mar 2328.05
Mar 2328.58
Mar 2328.45
Mar 2334.07
Feb 2328.9
Feb 2334.04
Feb 2332.49
Feb 2335.36
Jan 2335.1
Jan 2332.43
EV/EBITDA
5075100125150175med 86.87Mar 21May 21Jul 21Sep 21Nov 21Dec 21Feb 22
DNLI EV/EBITDA by year
PeriodEV/EBITDA
Feb 2284.18
Feb 2282.67
Feb 2290.3
Feb 2286.87
Jan 2281.96
Jan 2281.93
Jan 2290.27
Jan 22112.87
Dec 21123.09
Dec 21132.68
Dec 21132.07
Dec 21118.75
Dec 21116.33
Nov 21124.5
Nov 21131.53
Nov 21143.91
Nov 21158.13
Oct 2176.22
Oct 2175.12
Oct 2170.64
Oct 2181.34
Oct 2181.48
Sep 2181.52
Sep 2185.18
Sep 2182.78
Sep 2188.58
Aug 2185.82
Aug 2177.4
Aug 2184.98
Aug 2183.62
Jul 2180.29
Jul 21106.2
Jul 21107.3
Jul 21122.98
Jul 21132.56
Jun 21127.89
Jun 21125.98
Jun 21128.54
Jun 21107.69
May 21105.57
May 2196.13
May 2186.07
May 2186.87
Apr 2182.27
Apr 2176.12
Apr 2171.43
Apr 2168.48
Apr 2174.66
Mar 2173.52
Mar 2184.92
Mar 2189.44
Mar 2183.28
Feb 21101.43
Price/Operating Cashflow
10152025med 15.6Mar 21May 21Jul 21Sep 21Nov 21Dec 21Feb 22
DNLI Price/Operating Cashflow by year
PeriodPrice/Operating Cashflow
Feb 2210.93
Feb 2210.78
Feb 2211.53
Feb 2211.19
Jan 2210.71
Jan 2210.7
Jan 2211.53
Jan 2213.75
Dec 2114.75
Dec 2115.7
Dec 2115.64
Dec 2114.33
Dec 2114.09
Nov 2114.89
Nov 2115.58
Nov 2116.8
Nov 2118.2
Oct 2114.32
Oct 2114.16
Oct 2113.49
Oct 2115.08
Oct 2115.1
Sep 2115.1
Sep 2115.65
Sep 2115.29
Sep 2116.15
Aug 2115.74
Aug 2114.49
Aug 2115.62
Aug 2115.42
Jul 2114.66
Jul 2118.36
Jul 2118.51
Jul 2120.75
Jul 2122.12
Jun 2121.45
Jun 2121.18
Jun 2121.54
Jun 2118.57
May 2118.27
May 2116.92
May 2115.48
May 2115.6
Apr 2117.45
Apr 2116.4
Apr 2115.6
Apr 2115.09
Apr 2116.15
Mar 2115.95
Mar 2117.91
Mar 2118.68
Mar 2117.62
Feb 2120.73
Price to Book
123456med 3.14Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
DNLI Price to Book by year
PeriodPrice to Book
Sep 264.73
Sep 265
Aug 265.38
Aug 265.59
Aug 265.47
Aug 265.57
Jul 264.64
Jul 264.66
Jul 264.69
Jul 265.18
Jul 265.21
Jun 265.15
Jun 264.7
Jun 264.37
Jun 263.93
May 264.24
May 263.76
May 263.75
May 263.95
May 263.17
Apr 263.44
Apr 263.56
Apr 263.33
Apr 263.57
Mar 263.14
Mar 263.49
Mar 263.56
Mar 263.41
Feb 263.67
Feb 263.76
Feb 263.49
Feb 263.92
Jan 264.05
Jan 263.77
Jan 263.35
Jan 263.18
Jan 263.03
Dec 253.14
Dec 253.14
Dec 253.35
Dec 253.72
Nov 253.62
Nov 253.35
Nov 253.25
Nov 252.8
Oct 252.72
Oct 252.66
Oct 252.78
Oct 252.57
Oct 252.57
Sep 252.33
Sep 252.13
Sep 252.37
Sep 252.58
Aug 252.55
Aug 252.59
Aug 252.45
Aug 252.13
Aug 252.05
Jul 252.08
Jul 252.14
Jul 252.21
Jul 252.24
Jun 252.15
Jun 252.12
Jun 252.22
Jun 252.24
May 252.02
May 252.05
May 252.1
May 252.19
May 252.27
Apr 252.17
Apr 251.76
Apr 251.76
Apr 251.63
Mar 252.04
Mar 252
Mar 252.1
Mar 252.31
Feb 252.29
Feb 252.66
Feb 252.75
Feb 252.86
Jan 252.99
Jan 252.86
Jan 252.82
Jan 252.45
Jan 252.73
Dec 242.65
Dec 242.76
Dec 242.95
Dec 243.2
Nov 243.21
Nov 243.17
Nov 243.22
Nov 244.03
Nov 243.29
Oct 243.18
Oct 243.36
Denali Therapeutics Inc.
DNLI
Stockpicker

Video analysis: DNLI

All videos

No video analysis for this stock yet. Request one from our team.

Your email is used only to follow up on this request. We do not add you to marketing lists. Privacy Policy

News: DNLI

BlackRock Inc. Takes Position in Denali Therapeutics Inc. $DNLI

defenseworld.net · 26 Aug 2026

BlackRock Inc. Takes Position in Denali Therapeutics Inc. $DNLI

BlackRock Inc. bought a new stake in Denali Therapeutics Inc. (NASDAQ: DNLI) in the undefined quarter, according to its most recent filing with the Securities and Exchange Commission. The institutional investor bought 14,026,413 shares of the company's stock, valued at approximately $360,759,000. BlackRock Inc. owned about 8.84% of Denali Therapeutics at the end

DNLI Stock Gains 33.1% in Three Months: Buy, Sell or Hold the Stock?

zacks.com · 20 Aug 2026

DNLI Stock Gains 33.1% in Three Months: Buy, Sell or Hold the Stock?

Denali's Avlayah launch drives strong uptake and a 33.1% three-month stock gain, but regulatory and pipeline risks remain.

Denali Therapeutics: Bullish On Avlayah And Their Prospects

seekingalpha.com · 19 Aug 2026

Denali Therapeutics: Bullish On Avlayah And Their Prospects

AVLAYAH's approval has helped validate Denali Therapeutics' TransportVehicle platform. They're now moving into their commercial stage as a business. Early payer coverage and Q3 guidance support a credible launch ramp. However, AVLAYAH's US label limits its near-term potential. Zafinofusp alfa and four TV-enabled 2027 readouts provide meaningful pipeline upside beyond AVLAYAH.

Head to Head Comparison: Denali Therapeutics (NASDAQ:DNLI) versus Humacyte (NASDAQ:HUMA)

defenseworld.net · 19 Aug 2026

Head to Head Comparison: Denali Therapeutics (NASDAQ:DNLI) versus Humacyte (NASDAQ:HUMA)

Denali Therapeutics (NASDAQ: DNLI - Get Free Report) and Humacyte (NASDAQ: HUMA - Get Free Report) are both healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their analyst recommendations, dividends, valuation, institutional ownership, earnings, profitability and risk. Analyst Recommendations This is a summary of recent recommendations

Denali Therapeutics: AVLAYAH Converts A Platform Story Into A Commercial One

seekingalpha.com · 13 Aug 2026

Denali Therapeutics: AVLAYAH Converts A Platform Story Into A Commercial One

Denali Therapeutics (DNLI) is transitioning from a neuroscience platform to a commercial biotech with AVLAYAH, its FDA-approved rare-disease therapy. AVLAYAH's Q2 revenue of $3.6M is projected to triple in Q3, reflecting accelerating patient uptake and payer coverage progress. DNLI's TransportVehicle platform underpins a pipeline spanning enzymes, antibodies, and oligonucleotides, targeting both rare and large neurodegenerative markets.

Baillie Gifford Trims Denali Therapeutics (DNLI) Stake in June Reduction

gurufocus.com · 10 Aug 2026

Baillie Gifford Trims Denali Therapeutics (DNLI) Stake in June Reduction

On June 30, 2026, Baillie Gifford (Trades, Portfolio) executed a reduction of 106,249 shares in Denali Therapeutics Inc (NASDAQ: DNLI) at a traded price of $25.7

Denali Therapeutics Inc. $DNLI Shares Acquired by California State Teachers Retirement System

defenseworld.net · 10 Aug 2026

Denali Therapeutics Inc. $DNLI Shares Acquired by California State Teachers Retirement System

California State Teachers Retirement System increased its position in shares of Denali Therapeutics Inc. (NASDAQ: DNLI) by 25.6% during the first quarter, according to the company in its most recent Form 13F filing with the SEC. The fund owned 162,576 shares of the company's stock after acquiring an additional 33,167 shares during the

DNLI Q2 Loss Narrows, Avlayah Sales Drive Strong Launch Momentum

zacks.com · 7 Aug 2026

DNLI Q2 Loss Narrows, Avlayah Sales Drive Strong Launch Momentum

Denali Therapeutics narrows Q2 loss as Avlayah sales top estimates, with strong launch traction and pipeline updates shaping its outlook.

Similar companies

Disclaimer: The historical data presented on this platform is provided by Financial Modeling Prep. Stock Picker is a platform for informational purposes only and does not provide financial advice. Users are encouraged to conduct their own research and consult with a qualified financial advisor before making investment decisions.