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Aprea Therapeutics, Inc.

$0.77 -$0.08 (-9.27%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$0.79
Day Range
$0.77$0.82
Year Range
$0.55$1.69
Market Cap
9.58M
AVG Volume
216.41K
Trailing/Forward PE
-0.6/-
PEG ratio
-0.52
Dividend Yield
-
Next Earnings Date
2026-11-11
Primary Exchange
NASDAQUS
Revenue (USD)
0500K1M1.5M2M2019202020212022202320242025
APRE Revenue (USD) by year
PeriodRevenue (USD)
2025280.57K
20241.5M
2023583.23K
20220
20210
20200
20190
Net Income (USD)
-150M-100M-50M02019202020212022202320242025
APRE Net Income (USD) by year
PeriodNet Income (USD)
2025-12.6M
2024-12.96M
2023-14.29M
2022-112.66M
2021-37.13M
2020-53.48M
2019-28.06M
Operating Income (USD)
-150M-100M-50M02019202020212022202320242025
APRE Operating Income (USD) by year
PeriodOperating Income (USD)
2025-13.23M
2024-14.32M
2023-15.47M
2022-113.39M
2021-37.45M
2020-52.81M
2019-29.54M
EBITDA (USD)
-60M-40M-20M02019202020212022202320242025
APRE EBITDA (USD) by year
PeriodEBITDA (USD)
2025-12.58M
2024-12.94M
2023-14.28M
2022-36.78M
2021-37.38M
2020-52.58M
2019-31.97M
Cash Flows (USD)
-60M-40M-20M02019202020212022202320242025
APRE Cash Flows (USD) by year
PeriodCash Flows (USD)
2025-12.89M
2024-13.57M
2023-12.4M
2022-25.01M
2021-37.69M
2020-43.56M
2019-26.67M
EPS (USD)
-1000-750-500-25002019202020212022202320242025
APRE EPS (USD) by year
PeriodEPS (USD)
2025-1.98
2024-2.38
2023-3.92
2022-930.85
2021-34.91
2020-50.6
2019-29.58
Expenses (USD)
050M100M150MR&DSG&ACapex2019202020212022202320242025
APRE Expenses (USD) by year
PeriodExpenses (USD)
202513.52M
202415.84M
202316.15M
2022113.39M
202137.45M
202052.84M
201929.58M
Cash & Debt (USD)
050M100M150M2019202020212022202320242025
APRE Cash & Debt (USD) by year
PeriodCash & Debt (USD)
202514.6M
202422.85M
202321.61M
202228.79M
202153.08M
202089.02M
2019130.09M
Debt ratios
00.10.20.32022202320242025
APRE Debt ratios by year
PeriodDebt ratios
20250.19
20240.23
20230.15
20220.18
Margins
-1500%-1000%-500%0%202320242025
APRE Margins by year
PeriodMargins
2025-1466.53%
2024-523.16%
2023-1207.8%
Return on Capital
-600%-400%-200%0%2019202020212022202320242025
APRE Return on Capital by year
PeriodReturn on Capital
2025-101.27%
2024-67.12%
2023-78.22%
2022-439.34%
2021-74.99%
2020-69.1%
2019-22.58%
Shares Outstanding
02M4M6M8M2019202020212022202320242025
APRE Shares Outstanding by year
PeriodShares Outstanding
20257.69M
20245.95M
20233.74M
20223.73M
20211.08M
20201.06M
20191.02M
Book Value Per Share (USD)
0501001502019202020212022202320242025
APRE Book Value Per Share (USD) by year
PeriodBook Value Per Share (USD)
20251.62
20243.24
20234.89
20226.87
202145.97
202073.06
2019122.3
Total Assets (USD)
050M100M150M2019202020212022202320242025
APRE Total Assets (USD) by year
PeriodTotal Assets (USD)
202515.93M
202423.98M
202322.65M
202230.16M
202156.82M
202092.81M
2019133.61M
Employee Count
051015202019202020212022202320242025
APRE Employee Count by year
PeriodEmployee Count
20258
20248
20237
20229
202116
202017
201913
Free Cash Flow Yield
-400%-300%-200%-100%0%med -137.82%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
APRE Free Cash Flow Yield by year
PeriodFree Cash Flow Yield
Sep 26-29.43%
Sep 26-28.68%
Aug 26-27.16%
Aug 26-35.58%
Aug 26-33.5%
Aug 26-240.42%
Jul 26-252.17%
Jul 26-247.39%
Jul 26-220.36%
Jul 26-209.86%
Jul 26-211%
Jun 26-197.91%
Jun 26-218.67%
Jun 26-227.88%
Jun 26-210.88%
May 26-175.16%
May 26-164.58%
May 26-168.1%
May 26-171.16%
May 26-205.04%
Apr 26-180.37%
Apr 26-167.72%
Apr 26-182.94%
Apr 26-234.45%
Mar 26-245.57%
Mar 26-220.05%
Mar 26-286.62%
Mar 26-234.34%
Feb 26-230.12%
Feb 26-278.38%
Feb 26-346.17%
Feb 26-305.73%
Jan 26-265.02%
Jan 26-254.16%
Jan 26-237.03%
Jan 26-223.19%
Jan 26-247.31%
Dec 25-215.22%
Dec 25-226.83%
Dec 25-225.64%
Dec 25-199.01%
Nov 25-167.42%
Nov 25-180.3%
Nov 25-174.34%
Nov 25-170.28%
Oct 25-149.6%
Oct 25-149.6%
Oct 25-133.4%
Oct 25-147.5%
Oct 25-139.63%
Sep 25-143.45%
Sep 25-145.45%
Sep 25-136%
Sep 25-135.12%
Aug 25-133.4%
Aug 25-126.94%
Aug 25-123.93%
Aug 25-130.13%
Aug 25-133.26%
Jul 25-117.05%
Jul 25-133.26%
Jul 25-127.87%
Jul 25-127.14%
Jun 25-131.68%
Jun 25-134.89%
Jun 25-120.23%
Jun 25-126.41%
May 25-127.14%
May 25-132.47%
May 25-118.93%
May 25-140.69%
May 25-123.2%
Apr 25-143.35%
Apr 25-151.95%
Apr 25-147.05%
Apr 25-134.07%
Mar 25-109.05%
Mar 25-98.15%
Mar 25-97.74%
Mar 25-100.68%
Feb 25-92.72%
Feb 25-89.53%
Feb 25-65.34%
Feb 25-61.25%
Jan 25-59.99%
Jan 25-55.85%
Jan 25-60.93%
Jan 25-64.09%
Jan 25-60.46%
Dec 24-69.61%
Dec 24-76.91%
Dec 24-73.3%
Dec 24-67.02%
Nov 24-80.89%
Nov 24-81.45%
Nov 24-72.18%
Nov 24-66.08%
Nov 24-59.26%
Oct 24-56.94%
Oct 24-52.8%
Price to Sales
020406080med 12.2Nov 24Feb 25Jun 25Sep 25Jan 26Apr 26Aug 26
APRE Price to Sales by year
PeriodPrice to Sales
Aug 2642.33
Jul 2640.36
Jul 2641.14
Jul 2646.18
Jul 2648.49
Jul 2648.23
Jun 2651.42
Jun 2646.54
Jun 2644.66
Jun 2648.26
May 2658.1
May 2661.84
May 2660.54
May 2626.85
May 2622.41
Apr 2625.48
Apr 2627.4
Apr 2625.12
Apr 2619.6
Mar 2618.71
Mar 2620.88
Mar 269.64
Mar 2611.79
Feb 2612.01
Feb 269.93
Feb 267.98
Feb 269.04
Jan 2610.43
Jan 2610.88
Jan 2611.66
Jan 2612.38
Jan 2611.18
Dec 2512.84
Dec 2512.19
Dec 2512.25
Dec 2513.89
Nov 2516.51
Nov 2515.33
Nov 2515.85
Nov 258.9
Oct 2510.13
Oct 2510.13
Oct 2511.36
Oct 2510.27
Oct 2510.85
Sep 2510.56
Sep 2510.42
Sep 2511.14
Sep 2511.21
Aug 2511.36
Aug 2511.94
Aug 2512.22
Aug 257.93
Aug 257.75
Jul 258.82
Jul 257.75
Jul 258.07
Jul 258.12
Jun 257.84
Jun 257.65
Jun 258.59
Jun 258.17
May 258.12
May 257.79
May 258.68
May 256.42
May 257.33
Apr 256.3
Apr 255.94
Apr 256.14
Apr 256.74
Mar 258.28
Mar 2510.83
Mar 2510.88
Mar 2510.56
Feb 2511.46
Feb 2511.87
Feb 2516.27
Feb 2517.35
Jan 2517.72
Jan 2519.03
Jan 2517.45
Jan 2516.58
Jan 2517.58
Dec 2415.27
Dec 2413.82
Dec 2414.5
Dec 2415.86
Nov 2413.14
Nov 2413.05
Nov 2414.73
Nov 2416.09
Nov 2418.24
Oct 2418.99
Oct 2420.48
Oct 2412.1
Oct 2412.1
Sep 2412.8
Sep 2414.57
Sep 2414.66
Price to Book
00.511.5med 0.64Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
APRE Price to Book by year
PeriodPrice to Book
Sep 261.08
Sep 261.1
Aug 261.17
Aug 260.89
Aug 260.95
Aug 260.12
Jul 260.11
Jul 260.11
Jul 260.13
Jul 260.13
Jul 260.13
Jun 260.14
Jun 260.13
Jun 260.12
Jun 260.13
May 260.16
May 260.17
May 260.17
May 260.61
May 260.51
Apr 260.57
Apr 260.62
Apr 260.57
Apr 260.44
Mar 260.42
Mar 260.47
Mar 260.4
Mar 260.49
Feb 260.5
Feb 260.41
Feb 260.33
Feb 260.38
Jan 260.44
Jan 260.45
Jan 260.49
Jan 260.52
Jan 260.47
Dec 250.54
Dec 250.51
Dec 250.51
Dec 250.58
Nov 250.69
Nov 250.64
Nov 250.66
Nov 250.56
Oct 250.63
Oct 250.63
Oct 250.71
Oct 250.64
Oct 250.68
Sep 250.66
Sep 250.65
Sep 250.7
Sep 250.7
Aug 250.71
Aug 250.75
Aug 250.77
Aug 250.66
Aug 250.64
Jul 250.73
Jul 250.64
Jul 250.67
Jul 250.67
Jun 250.65
Jun 250.63
Jun 250.71
Jun 250.67
May 250.67
May 250.64
May 250.72
May 250.5
May 250.57
Apr 250.49
Apr 250.46
Apr 250.48
Apr 250.52
Mar 250.64
Mar 250.65
Mar 250.65
Mar 250.63
Feb 250.68
Feb 250.71
Feb 250.97
Feb 251.04
Jan 251.06
Jan 251.14
Jan 251.04
Jan 250.99
Jan 251.05
Dec 240.91
Dec 240.83
Dec 240.87
Dec 240.95
Nov 240.78
Nov 240.78
Nov 240.88
Nov 240.96
Nov 240.87
Oct 240.9
Oct 240.97
Aprea Therapeutics, Inc.
APRE
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News: APRE

Aprea Therapeutics to Present at H.C. Wainwright 28th Annual Global Investment Conference

globenewswire.com · 10 Sep 2026

Aprea Therapeutics to Present at H.C. Wainwright 28th Annual Global Investment Conference

DOYLESTOWN, Pa., Sept. 10, 2026 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers, today announced that Oren Gilad, Ph.D., President and Chief Executive Officer, will present at the H.C. Wainwright 28th Annual Global Investment Conference, to be held in person and virtually September 14-16, 2026.

Aprea Therapeutics Announces Expansion of Intellectual Property Portfolio for Precision Oncology Programs

globenewswire.com · 28 Aug 2026

Aprea Therapeutics Announces Expansion of Intellectual Property Portfolio for Precision Oncology Programs

Company Strengthens Global Intellectual Property Portfolio with 28 Issued and 30 Pending Patents Company Strengthens Global Intellectual Property Portfolio with 28 Issued and 30 Pending Patents

Aprea Therapeutics Announces Second Quarter 2026 Financial Results

globenewswire.com · 12 Aug 2026

Aprea Therapeutics Announces Second Quarter 2026 Financial Results

Enrollment in the ongoing Phase 1 dose escalation ACESOT-1051 trial of oral WEE1 inhibitor APR-1051 is accelerating as dose escalation advances

Lipocine Appoints Michael J. Grissinger to Board of Directors

prnewswire.com · 3 Aug 2026

Lipocine Appoints Michael J. Grissinger to Board of Directors

SALT LAKE CITY, Aug. 3, 2026 /PRNewswire/ -- Lipocine Inc. (NASDAQ: LPCN), a biopharmaceutical company leveraging its proprietary technology platform to augment therapeutics through effective oral delivery, today announced the appointment of Michael J. Grissinger to its Board of Directors, effective August 3, 2026.

Aprea Therapeutics Provides ACESOT-1051 Program Update for WEE1 Inhibitor APR-1051: Accelerating and Expanding Enrollment. Clinical Data Presentation Planned for Q4 2026

globenewswire.com · 30 Jul 2026

Aprea Therapeutics Provides ACESOT-1051 Program Update for WEE1 Inhibitor APR-1051: Accelerating and Expanding Enrollment. Clinical Data Presentation Planned for Q4 2026

Next clinical data update from the ongoing Phase 1 dose escalation ACESOT-1051 trial anticipated at a medical meeting in Q4 2026, providing a near-term opportunity to demonstrate continued clinical progress with APR-1051 Enrollment in ACESOT-1051 is accelerating as the Company advances dose escalation and amasses the clinical data needed to inform dose selection and subsequent development Aprea plans to advance APR-1051 in uterine serous carcinoma (USC) and Cyclin E–overexpressing platinum-resistant ovarian cancer (PROC) while also evaluating combination regimens with standard of care in HPV-positive head and neck cancer and colorectal cancer, utilizing dose levels that have shown single-agent activity and cleared safety review The expanded development strategy builds on emerging single-agent activity and positions APR-1051 across biomarker-defined indications where WEE1 inhibition may address significant unmet medical need DOYLESTOWN, Pa., July 30, 2026 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers, today provided an update on the ongoing Phase 1 dose escalation ACESOT-1051 trial of its oral WEE1 inhibitor APR-1051.

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