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Upstream Bio, Inc.

$5.73 -$21.34 (-78.83%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$5.75
Day Range
$5.65$5.84
Year Range
$5.65$33.68
Market Cap
311.83M
AVG Volume
605.74K
Trailing/Forward PE
-1.98/-
PEG ratio
0.51
Dividend Yield
-
Next Earnings Date
2026-11-04
Primary Exchange
NASDAQUS
Revenue (USD) · TTM
01M2M3M4M24 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
UPB Revenue (USD) · TTM by quarter
PeriodRevenue (USD) · TTM
26 Q23.16M
26 Q13.32M
25 Q42.85M
25 Q32.8M
25 Q22.72M
25 Q12.3M
24 Q42.37M
24 Q32.21M
24 Q22.22M
Net Income (USD) · TTM
-200M-150M-100M-50M024 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
UPB Net Income (USD) · TTM by quarter
PeriodNet Income (USD) · TTM
26 Q2-156.5M
26 Q1-156.76M
25 Q4-143.44M
25 Q3-122.23M
25 Q2-104.47M
25 Q1-79.18M
24 Q4-62.81M
24 Q3-53.4M
24 Q2-40.51M
Operating Income (USD) · TTM
-200M-150M-100M-50M024 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
UPB Operating Income (USD) · TTM by quarter
PeriodOperating Income (USD) · TTM
26 Q2-169.98M
26 Q1-171.96M
25 Q4-160.36M
25 Q3-140.51M
25 Q2-121.57M
25 Q1-94.76M
24 Q4-77.76M
24 Q3-65.78M
24 Q2-56.27M
EBITDA (USD) · TTM
-200M-150M-100M-50M024 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
UPB EBITDA (USD) · TTM by quarter
PeriodEBITDA (USD) · TTM
26 Q2-156.35M
26 Q1-156.57M
25 Q4-143.25M
25 Q3-122.05M
25 Q2-104.32M
25 Q1-79.06M
24 Q4-62.72M
24 Q3-53.34M
24 Q2-40.45M
Cash Flows (USD) · TTM
-150M-100M-50M024 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
UPB Cash Flows (USD) · TTM by quarter
PeriodCash Flows (USD) · TTM
26 Q2-136.34M
26 Q1-140.01M
25 Q4-133.32M
25 Q3-122.44M
25 Q2-114.54M
25 Q1-83.29M
24 Q4-59.68M
24 Q3-56M
24 Q2-46.53M
EPS (USD) · TTM
-3-2-1024 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
UPB EPS (USD) · TTM by quarter
PeriodEPS (USD) · TTM
26 Q2-2.9
26 Q1-2.91
25 Q4-2.67
25 Q3-2.29
25 Q2-2.07
25 Q1-1.71
24 Q4-1.47
24 Q3-1.47
24 Q2-1.23
Expenses (USD) · TTM
050M100M150M200MR&DSG&ACapex24 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
UPB Expenses (USD) · TTM by quarter
PeriodExpenses (USD) · TTM
26 Q2173.14M
26 Q1175.33M
25 Q4163.26M
25 Q3143.5M
25 Q2124.85M
25 Q197.57M
24 Q480.64M
24 Q368.31M
24 Q258.49M
Shares Outstanding · TTM
-15M-10M-5M024 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
UPB Shares Outstanding · TTM by quarter
PeriodShares Outstanding · TTM
26 Q2-14.1M
26 Q1-12.34M
25 Q4-10.33M
25 Q3-9.91M
25 Q2-9.18M
25 Q1-8M
24 Q4-6M
24 Q3-4.73M
24 Q2-3.55M
Employee Count
02040608020242025
UPB Employee Count by quarter
PeriodEmployee Count
202575
202452
Free Cash Flow Yield
-60%-40%-20%0%med -13.6%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
UPB Free Cash Flow Yield by quarter
PeriodFree Cash Flow Yield
Sep 26-43.61%
Sep 26-41.57%
Aug 26-37.35%
Aug 26-35.85%
Aug 26-35.34%
Aug 26-35.54%
Jul 26-40.84%
Jul 26-40.2%
Jul 26-36.76%
Jul 26-34.22%
Jul 26-34.31%
Jun 26-38.18%
Jun 26-41.23%
Jun 26-42.24%
Jun 26-36.55%
May 26-30.82%
May 26-30.79%
May 26-28.35%
May 26-27.04%
May 26-26.15%
Apr 26-26.43%
Apr 26-24.61%
Apr 26-23.43%
Apr 26-25.87%
Mar 26-28.35%
Mar 26-26.19%
Mar 26-24.6%
Mar 26-29.64%
Feb 26-29.56%
Feb 26-28.1%
Feb 26-25.95%
Feb 26-8.67%
Jan 26-7.3%
Jan 26-7.56%
Jan 26-7.32%
Jan 26-7.63%
Jan 26-8.39%
Dec 25-7.7%
Dec 25-7.74%
Dec 25-8.37%
Dec 25-8.18%
Nov 25-7.94%
Nov 25-8.89%
Nov 25-9.26%
Nov 25-9.89%
Oct 25-8.24%
Oct 25-9.74%
Oct 25-10.16%
Oct 25-10.86%
Oct 25-11.43%
Sep 25-12.34%
Sep 25-13%
Sep 25-12.12%
Sep 25-10.67%
Aug 25-12.43%
Aug 25-12.08%
Aug 25-11.25%
Aug 25-13.31%
Aug 25-10%
Jul 25-11.4%
Jul 25-14.49%
Jul 25-13.53%
Jul 25-13.87%
Jun 25-14.21%
Jun 25-14.28%
Jun 25-13.67%
Jun 25-13.78%
May 25-16.83%
May 25-16.96%
May 25-17.98%
May 25-17.61%
May 25-13.45%
Apr 25-13.86%
Apr 25-13.24%
Apr 25-15.77%
Apr 25-19.06%
Mar 25-16.92%
Mar 25-15.26%
Mar 25-12.1%
Mar 25-13%
Feb 25-13.75%
Feb 25-13.67%
Feb 25-14.35%
Feb 25-13.77%
Jan 25-10.13%
Jan 25-10.5%
Jan 25-9.92%
Jan 25-7.96%
Jan 25-5.94%
Dec 24-5.68%
Dec 24-6.73%
Dec 24-5.39%
Dec 24-4.57%
Nov 24-4.99%
Nov 24-4.98%
Nov 24-3.56%
Nov 24-3.46%
Nov 24-3.66%
Oct 24-3.62%
Oct 24-3.5%
Price to Sales
0200400600800med 250.44Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
UPB Price to Sales by quarter
PeriodPrice to Sales
Sep 2699.01
Sep 26103.85
Aug 26115.6
Aug 26120.44
Aug 26122.16
Aug 26118.58
Jul 26103.2
Jul 26104.84
Jul 26114.65
Jul 26123.16
Jul 26122.83
Jun 26110.4
Jun 26102.22
Jun 2699.77
Jun 26115.3
May 26136.73
May 26136.89
May 26148.67
May 26172.75
May 26178.64
Apr 26176.74
Apr 26189.85
Apr 26199.35
Apr 26180.54
Mar 26164.77
Mar 26167.05
Mar 26177.84
Mar 26147.59
Feb 26147.98
Feb 26155.68
Feb 26168.59
Feb 26504.82
Jan 26598.85
Jan 26578.42
Jan 26597.31
Jan 26573.22
Jan 26521.58
Dec 25568.02
Dec 25565.51
Dec 25522.93
Dec 25534.69
Nov 25551.06
Nov 25492.3
Nov 25472.64
Nov 25442.39
Oct 25510.46
Oct 25431.67
Oct 25414.09
Oct 25387.43
Oct 25367.89
Sep 25340.83
Sep 25323.45
Sep 25346.95
Sep 25394.35
Aug 25338.26
Aug 25348.14
Aug 25373.81
Aug 25315.95
Aug 25362.9
Jul 25318.3
Jul 25250.34
Jul 25268.09
Jul 25261.55
Jun 25255.24
Jun 25254.08
Jun 25265.29
Jun 25263.18
May 25215.55
May 25213.91
May 25201.77
May 25205.97
May 25187.17
Apr 25181.75
Apr 25190.2
Apr 25159.66
Apr 25132.15
Mar 25148.83
Mar 25165.07
Mar 25208.18
Mar 25193.67
Feb 25184.48
Feb 25185.64
Feb 25176.8
Feb 25184.24
Jan 25250.54
Jan 25241.7
Jan 25255.89
Jan 25318.7
Jan 25426.88
Dec 24446.42
Dec 24377.1
Dec 24471.08
Dec 24554.59
Nov 24508.76
Nov 24420.49
Nov 24588.55
Nov 24605.19
Nov 24572.36
Oct 24579.3
Oct 24598.25
Price to Book
012345med 1.39Apr 25Jul 25Oct 25Jan 26Mar 26Jun 26Sep 26
UPB Price to Book by quarter
PeriodPrice to Book
Sep 261.15
Sep 261.21
Aug 261.35
Aug 261.4
Aug 261.42
Aug 261.3
Jul 261.13
Jul 261.15
Jul 261.25
Jul 261.35
Jul 261.34
Jun 261.21
Jun 261.12
Jun 261.09
Jun 261.26
May 261.49
May 261.5
May 261.62
May 261.45
May 261.5
Apr 261.48
Apr 261.59
Apr 261.67
Apr 261.52
Mar 261.38
Mar 261.24
Mar 261.31
Mar 261.09
Feb 261.09
Feb 261.15
Feb 261.25
Feb 263.73
Jan 264.43
Jan 264.28
Jan 264.42
Jan 264.24
Jan 263.86
Dec 254.2
Dec 254.18
Dec 253.87
Dec 253.95
Nov 254.07
Nov 253.64
Nov 253.49
Nov 253.27
Oct 253.4
Oct 252.88
Oct 252.76
Oct 252.58
Oct 252.45
Sep 252.27
Sep 252.15
Sep 252.31
Sep 252.63
Aug 252.25
Aug 252.32
Aug 252.49
Aug 252.1
Aug 251.87
Jul 251.64
Jul 251.29
Jul 251.38
Jul 251.35
Jun 251.32
Jun 251.31
Jun 251.37
Jun 251.36
May 251.11
May 251.1
May 251.04
May 251.06
May 250.94
Apr 250.92
Apr 250.96
Apr 250.81
Apr 250.67
Mar 250.75
Mar 250.83
Mar 251.05
Mar 250.98
Upstream Bio, Inc.
UPB
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News: UPB

Upstream Bio Presents Results from the Phase 2 VALIANT Trial of Verekitug for the Treatment of Severe Asthma in Oral Presentation at ERS Congress 2026

globenewswire.com · 8 Sep 2026

Upstream Bio Presents Results from the Phase 2 VALIANT Trial of Verekitug for the Treatment of Severe Asthma in Oral Presentation at ERS Congress 2026

– Verekitug, 100 mg dosed every 12 weeks, reduced AAER by 56% compared to placebo in patients with severe asthma – – Verekitug also delivered clinically meaningful improvements in lung function (FEV 1 ) and exhaled nitric oxide (FeNO) with every 12-week dosing – – The Company remains on track to initiate Phase 3 trials in severe asthma and CRSwNP in Q1 2027 , designed to deliver best-in-class efficacy in both indications by evaluating a 400 mg quarterly regimen of verekitug in broad patient populations – WALTHAM, Mass., Sept. 08, 2026 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for severe inflammatory respiratory diseases, today presented results from the Phase 2 VALIANT clinical trial evaluating the safety and efficacy of verekitug in adults with severe asthma in a late-breaking oral presentation at the European Respiratory Society (ERS) Congress 2026 in Barcelona.

Upstream Bio Announces Pivotal Phase 3 Development Plans for Verekitug in Both Severe Asthma and CRSwNP

globenewswire.com · 1 Sep 2026

Upstream Bio Announces Pivotal Phase 3 Development Plans for Verekitug in Both Severe Asthma and CRSwNP

– Following productive FDA discussions, Upstream Bio will study 400 mg of verekitug administered every 12 weeks, versus placebo, in severe asthma and CRSwNP with one pivotal Phase 3 trial in each indication – – The Company's Phase 3 strategy is designed to deliver best-in-class efficacy across both indications by evaluating a high-dose, quarterly regimen of verekitug in broad patient populations – – The Company remains on track to initiate both Phase 3 trials in Q1 2027 – WALTHAM, Mass., Sept. 01, 2026 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for severe inflammatory respiratory diseases, today announced its pivotal Phase 3 development plans for verekitug in severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).

Fannie Mae Announces Sale of Non-Performing Loans

gurufocus.com · 19 Aug 2026

Fannie Mae Announces Sale of Non-Performing Loans

Fannie Mae Announces Sale of Non-Performing Loans PR Newswire WASHINGTON, Aug. 19, 2026

Upstream Bio, Inc. (UPB) Reports Q2 Loss, Tops Revenue Estimates

zacks.com · 11 Aug 2026

Upstream Bio, Inc. (UPB) Reports Q2 Loss, Tops Revenue Estimates

Upstream Bio, Inc. (UPB) came out with a quarterly loss of $0.73 per share versus the Zacks Consensus Estimate of a loss of $0.78. This compares to a loss of $0.74 per share a year ago.

Upstream Bio, Inc. (UPB) Upgraded to Buy: What Does It Mean for the Stock?

zacks.com · 14 Jul 2026

Upstream Bio, Inc. (UPB) Upgraded to Buy: What Does It Mean for the Stock?

Upstream Bio, Inc. (UPB) has been upgraded to a Zacks Rank #2 (Buy), reflecting growing optimism about the company's earnings prospects. This might drive the stock higher in the near term.

Fannie Mae Announces the Results of its Thirty-sixth Reperforming Loan Sale Transaction

gurufocus.com · 29 Jun 2026

Fannie Mae Announces the Results of its Thirty-sixth Reperforming Loan Sale Transaction

Fannie Mae Announces the Results of its Thirty-sixth Reperforming Loan Sale Transaction PR Newswire WASHINGTON,

Upstream Bio Presents New Responder Analyses Demonstrating Clinically Meaningful Improvements in CRSwNP in Significant Majority of Participants Treated with Verekitug in the Phase 2 VIBRANT Trial at EAACI 2026

globenewswire.com · 14 Jun 2026

Upstream Bio Presents New Responder Analyses Demonstrating Clinically Meaningful Improvements in CRSwNP in Significant Majority of Participants Treated with Verekitug in the Phase 2 VIBRANT Trial at EAACI 2026

– Verekitug, administered once every three months, led to clinically meaningful improvements in nasal polyp score (NPS) in approximately 80% of participants –

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