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Spero Therapeutics, Inc.

$1.13 -$1.22 (-51.91%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$1.12
Day Range
$1.13$1.15
Year Range
$1.08$3.08
Market Cap
65.43M
AVG Volume
1.26M
Trailing/Forward PE
8.07/1.69
PEG ratio
-0.02
Dividend Yield
-
Next Earnings Date
2026-11-12
Primary Exchange
NASDAQUS
Revenue (USD)
050M100M150M201720182019202020212022202320242025
SPRO Revenue (USD) by year
PeriodRevenue (USD)
202560.38M
202442.91M
2023103.78M
202248.58M
202112.86M
20209.33M
20199.77M
20183.97M
20171.98M
Net Income (USD)
-100M-50M050M201720182019202020212022202320242025
SPRO Net Income (USD) by year
PeriodNet Income (USD)
20258.57M
2024-68.57M
202322.81M
2022-46.41M
2021-89.76M
2020-78.28M
2019-60.92M
2018-41.66M
2017-39.65M
Operating Income (USD)
-100M-50M050M201720182019202020212022202320242025
SPRO Operating Income (USD) by year
PeriodOperating Income (USD)
20256.31M
2024-73.36M
202321.48M
2022-42.2M
2021-87.97M
2020-79.11M
2019-63.22M
2018-42.81M
2017-41.73M
EBITDA (USD)
-100M-50M050M201720182019202020212022202320242025
SPRO EBITDA (USD) by year
PeriodEBITDA (USD)
20257.54M
2024-68.81M
202330.14M
2022-42.94M
2021-87.17M
2020-78.35M
2019-62.17M
2018-42.4M
2017-40.17M
Cash Flows (USD)
-100M-75M-50M-25M0201720182019202020212022202320242025
SPRO Cash Flows (USD) by year
PeriodCash Flows (USD)
2025-12.62M
2024-23.44M
2023-32.99M
2022-7.86M
2021-64.31M
2020-86.03M
2019-50.33M
2018-42.04M
2017-39.14M
EPS (USD)
-6-4-202201720182019202020212022202320242025
SPRO EPS (USD) by year
PeriodEPS (USD)
20250.12
2024-1.28
20230.44
2022-1.74
2021-2.9
2020-3.58
2019-3.3
2018-2.63
2017-4.6
Expenses (USD)
-50M050M100M150MR&DSG&ACapex201720182019202020212022202320242025
SPRO Expenses (USD) by year
PeriodExpenses (USD)
202559.64M
2024120.46M
202376.99M
202284.2M
2021106.29M
202088.8M
201983.48M
201849.19M
201743.74M
Cash & Debt (USD)
050M100M150MCashShort Term Debt201720182019202020212022202320242025
SPRO Cash & Debt (USD) by year
PeriodCash & Debt (USD)
202540.27M
202452.89M
202376.33M
2022109.11M
2021146.4M
2020126.91M
201982.05M
2018115.44M
201787.29M
Debt ratios
00.20.40.6202020212022202320242025
SPRO Debt ratios by year
PeriodDebt ratios
20250.5
20240.29
20230.4
20220.38
20210.51
20200.53
Margins
-400%-200%0%200%201720182019202020212022202320242025
SPRO Margins by year
PeriodMargins
202577.47%
2024-175.81%
202333.95%
2022100%
2021-177.1%
2020-308.81%
2019-163.47%
2018100%
2017100%
Return on Capital
-150%-100%-50%0%50%2019202020212022202320242025
SPRO Return on Capital by year
PeriodReturn on Capital
202514.52%
2024-148.66%
202321.34%
2022-61.13%
2021-101.66%
2020-59.29%
2019-81.7%
Shares Outstanding
020M40M60M201720182019202020212022202320242025
SPRO Shares Outstanding by year
PeriodShares Outstanding
202556.02M
202454.04M
202353M
202248.72M
202132.13M
202027.37M
201919.05M
201817.74M
20179.27M
Dividends (USD)
00.020.040.06201020112012201320142015
SPRO Dividends (USD) by year
PeriodDividends (USD)
20150.04
20140.06
20130.06
20120.04
20110.04
20100.04
Employee Count
050100150201720182019202020212022202320242025
SPRO Employee Count by year
PeriodEmployee Count
202525
202432
202346
202235
2021146
202089
201957
201841
201735
Book Value Per Share (USD)
0246201720182019202020212022202320242025
SPRO Book Value Per Share (USD) by year
PeriodBook Value Per Share (USD)
20251.05
20240.85
20232.02
20221.56
20212.75
20204.82
20193.91
20180
20170
Total Assets (USD)
050M100M150M200M201720182019202020212022202320242025
SPRO Total Assets (USD) by year
PeriodTotal Assets (USD)
202568.92M
2024110.54M
2023182.39M
2022124.8M
2021171.07M
2020153.45M
2019106.1M
2018129.01M
201793.48M
PE Ratio
05101520med 7.9Apr 24Jul 24Oct 24Jan 25Mar 26Jun 26Sep 26
SPRO PE Ratio by year
PeriodPE Ratio
Sep 268.87
Sep 269.5
Aug 269.42
Aug 269.58
Aug 269.66
Aug 264.74
Jul 264.4
Jul 264.47
Jul 265.94
Jul 267.9
Jul 268.27
Jun 268.5
Jun 268.57
Jun 2610.72
Jun 2610.6
May 2610.64
May 2610.38
May 2610.49
May 2616.73
May 2616.21
Apr 2617.91
Apr 2617.97
Apr 2617.45
Apr 2615.88
Mar 2615.23
Mar 2512.67
Mar 2512.05
Mar 2512
Feb 2511.95
Feb 2512.8
Feb 2512.56
Feb 2512.61
Jan 2513.2
Jan 2513.37
Jan 2514.02
Jan 2515.1
Jan 2516.95
Dec 2415.87
Dec 2414.72
Dec 2416.49
Dec 2418.03
Nov 2417.56
Nov 2417.87
Nov 2418.18
Nov 244.08
Nov 243.65
Oct 244.11
Oct 243.96
Oct 243.86
Oct 244.02
Sep 244.05
Sep 244.11
Sep 244.24
Sep 244.08
Aug 244.24
Aug 244.24
Aug 243.68
Aug 243.96
Aug 243
Jul 243.29
Jul 243.2
Jul 243.25
Jul 243
Jun 242.97
Jun 243.13
Jun 243.11
Jun 243.22
May 243.25
May 243.36
May 243.64
May 243.81
May 243.79
Apr 243.39
Apr 243.25
Apr 243.81
Apr 243.83
Mar 244
Mar 244.07
Mar 244.16
Free Cash Flow Yield
-100%-50%0%50%med -22.1%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
SPRO Free Cash Flow Yield by year
PeriodFree Cash Flow Yield
Sep 2629.89%
Sep 2627.91%
Aug 2628.15%
Aug 2627.69%
Aug 2627.46%
Aug 2610.03%
Jul 2610.81%
Jul 2610.62%
Jul 268%
Jul 266.02%
Jul 265.75%
Jun 265.59%
Jun 265.55%
Jun 264.44%
Jun 264.48%
May 264.47%
May 264.58%
May 264.53%
May 26-8.8%
May 26-9.09%
Apr 26-8.22%
Apr 26-8.19%
Apr 26-8.44%
Apr 26-9.27%
Mar 26-9.67%
Mar 26-20.75%
Mar 26-19.06%
Mar 26-21.38%
Feb 26-22.66%
Feb 26-21.38%
Feb 26-20.57%
Feb 26-20.32%
Jan 26-22.45%
Jan 26-20.15%
Jan 26-20.4%
Jan 26-19.28%
Jan 26-20.92%
Dec 25-21.19%
Dec 25-21.19%
Dec 25-21.19%
Dec 25-21.76%
Nov 25-20.49%
Nov 25-21.29%
Nov 25-20.4%
Nov 25-23.46%
Oct 25-23.75%
Oct 25-26.11%
Oct 25-26.11%
Oct 25-25.65%
Oct 25-28.15%
Sep 25-30.53%
Sep 25-28.85%
Sep 25-30.37%
Sep 25-26.84%
Aug 25-27.88%
Aug 25-30.86%
Aug 25-30.21%
Aug 25-27.53%
Aug 25-26.21%
Jul 25-25.87%
Jul 25-25.44%
Jul 25-21.45%
Jul 25-20.72%
Jun 25-20.51%
Jun 25-19.96%
Jun 25-21.3%
Jun 25-24.11%
May 25-24.11%
May 25-86.58%
May 25-92.6%
May 25-69.97%
May 25-67.05%
Apr 25-59.82%
Apr 25-57.52%
Apr 25-72.31%
Apr 25-74.54%
Mar 25-56.6%
Mar 25-39.41%
Mar 25-41.41%
Mar 25-41.59%
Feb 25-41.77%
Feb 25-38.99%
Feb 25-39.75%
Feb 25-39.59%
Jan 25-37.82%
Jan 25-37.34%
Jan 25-35.6%
Jan 25-33.06%
Jan 25-29.45%
Dec 24-31.46%
Dec 24-33.92%
Dec 24-30.28%
Dec 24-27.69%
Nov 24-28.42%
Nov 24-27.93%
Nov 24-27.46%
Nov 24-20.2%
Nov 24-22.59%
Oct 24-20.04%
Oct 24-20.83%
Price to Sales
012345med 2.34Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
SPRO Price to Sales by year
PeriodPrice to Sales
Sep 261.52
Sep 261.63
Aug 261.62
Aug 261.65
Aug 261.66
Aug 261.32
Jul 261.22
Jul 261.24
Jul 261.65
Jul 262.2
Jul 262.3
Jun 262.36
Jun 262.38
Jun 262.98
Jun 262.95
May 262.96
May 262.89
May 262.92
May 262.38
May 262.3
Apr 262.54
Apr 262.55
Apr 262.48
Apr 262.25
Mar 262.16
Mar 263.73
Mar 264.06
Mar 263.62
Feb 263.41
Feb 263.62
Feb 263.76
Feb 263.81
Jan 263.45
Jan 263.84
Jan 263.79
Jan 264.01
Jan 263.7
Dec 253.65
Dec 253.65
Dec 253.65
Dec 253.56
Nov 253.78
Nov 253.63
Nov 253.79
Nov 252.98
Oct 252.95
Oct 252.68
Oct 252.68
Oct 252.73
Oct 252.49
Sep 252.29
Sep 252.43
Sep 252.3
Sep 252.61
Aug 252.51
Aug 252.27
Aug 252.32
Aug 252.72
Aug 252.86
Jul 252.89
Jul 252.94
Jul 253.49
Jul 253.61
Jun 253.65
Jun 253.75
Jun 253.52
Jun 253.11
May 253.11
May 250.86
May 250.81
May 250.78
May 250.81
Apr 250.91
Apr 250.95
Apr 250.76
Apr 250.73
Mar 250.97
Mar 250.44
Mar 250.42
Mar 250.42
Feb 250.41
Feb 250.44
Feb 250.44
Feb 250.44
Jan 250.46
Jan 250.46
Jan 250.49
Jan 250.52
Jan 250.59
Dec 240.55
Dec 240.51
Dec 240.57
Dec 240.62
Nov 240.61
Nov 240.62
Nov 240.63
Nov 240.63
Nov 240.56
Oct 240.63
Oct 240.61
EV/EBITDA
-1001020med 0.2Feb 24May 24Aug 24Nov 24Feb 25Jun 26Sep 26
SPRO EV/EBITDA by year
PeriodEV/EBITDA
Sep 262.18
Sep 262.78
Aug 262.71
Aug 262.86
Aug 262.93
Aug 261.24
Jul 260.9
Jul 260.97
Jul 262.47
Jul 264.48
Jul 264.86
Jun 265.09
Jun 265.17
Jun 267.36
Jun 267.25
May 267.28
May 267.01
May 267.13
May 2614.07
May 2613.48
Apr 2615.41
Apr 2615.48
Apr 2614.89
Apr 2613.1
Mar 2612.36
Mar 25-7.44
Mar 25-8.03
Mar 25-8.08
Feb 25-8.13
Feb 25-7.31
Feb 25-7.55
Feb 25-7.5
Jan 25-6.93
Jan 25-6.77
Jan 25-6.14
Jan 25-5.1
Jan 25-3.32
Dec 24-4.36
Dec 24-5.47
Dec 24-3.77
Dec 24-2.28
Nov 24-2.73
Nov 24-2.43
Nov 24-2.14
Nov 240.51
Nov 240.21
Oct 240.54
Oct 240.43
Oct 240.36
Oct 240.47
Sep 240.49
Sep 240.54
Sep 240.62
Sep 240.51
Aug 240.62
Aug 240.62
Aug 240.23
Aug 240.43
Aug 24-0.23
Jul 240
Jul 24-0.07
Jul 24-0.03
Jul 24-0.23
Jun 24-0.24
Jun 24-0.12
Jun 24-0.14
Jun 24-0.05
May 24-0.03
May 240.05
May 240.26
May 240.54
May 240.52
Apr 240.22
Apr 240.11
Apr 240.54
Apr 240.55
Mar 240.68
Mar 240.73
Mar 240.8
Mar 24-0.09
Mar 240.2
Feb 24-1.55
Feb 24-1.36
Feb 24-2.91
Feb 24-2.04
Jan 24-0.97
Jan 24-2.72
Jan 24-2.13
Jan 24-2.33
Dec 23-1.94
Dec 23-3.11
Dec 23-3.69
Dec 23-3.4
Dec 23-4.86
Nov 23-4.66
Nov 23-4.66
Price/Operating Cashflow
0102030med 5.56Jun 23Sep 23Nov 23Jan 24Mar 24Jul 26Sep 26
SPRO Price/Operating Cashflow by year
PeriodPrice/Operating Cashflow
Sep 263.35
Sep 263.58
Aug 263.55
Aug 263.61
Aug 263.64
Aug 269.97
Jul 269.25
Jul 269.41
Jul 2612.5
Jul 2616.61
Jul 2617.4
Jun 2617.88
Jun 2618.03
Jun 2622.54
Jun 2622.31
May 2622.38
May 2621.83
May 2622.07
Mar 243.02
Mar 243.07
Feb 242.75
Feb 242.78
Feb 242.49
Feb 242.66
Jan 242.86
Jan 242.53
Jan 242.64
Jan 242.6
Dec 232.67
Dec 232.46
Dec 232.35
Dec 232.4
Dec 232.13
Nov 232.16
Nov 232.16
Nov 234.82
Nov 235.17
Oct 234.43
Oct 234.65
Oct 234.91
Oct 234.95
Sep 235.25
Sep 235.25
Sep 235.56
Sep 235.9
Sep 236.6
Aug 235.56
Aug 235.56
Aug 236.08
Aug 2310.38
Jul 239.76
Jul 239.97
Jul 2310.38
Jul 2310.04
Jun 239.97
Jun 2311
Jun 2310.73
Jun 2312.24
Jun 2312.51
May 2312.17
May 2312.72
May 2312.72
Price to Book
0246med 2.57Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
SPRO Price to Book by year
PeriodPrice to Book
Sep 261.48
Sep 261.59
Aug 261.57
Aug 261.6
Aug 261.61
Aug 261.36
Jul 261.27
Jul 261.29
Jul 261.71
Jul 262.27
Jul 262.38
Jun 262.45
Jun 262.47
Jun 263.08
Jun 263.05
May 263.06
May 262.99
May 263.02
May 262.43
May 262.35
Apr 262.6
Apr 262.61
Apr 262.53
Apr 262.31
Mar 262.21
Mar 265.03
Mar 265.48
Mar 264.89
Feb 264.61
Feb 264.89
Feb 265.08
Feb 265.14
Jan 264.65
Jan 265.18
Jan 265.12
Jan 265.42
Jan 264.99
Dec 254.93
Dec 254.93
Dec 254.93
Dec 254.8
Nov 255.1
Nov 254.91
Nov 255.12
Nov 254.2
Oct 254.15
Oct 253.77
Oct 253.77
Oct 253.84
Oct 253.5
Sep 253.23
Sep 253.41
Sep 253.24
Sep 253.67
Aug 253.53
Aug 253.19
Aug 253.26
Aug 253.59
Aug 253.77
Jul 253.82
Jul 253.88
Jul 254.6
Jul 254.77
Jun 254.81
Jun 254.95
Jun 254.63
Jun 254.09
May 254.09
May 251.14
May 251.07
May 250.73
May 250.76
Apr 250.85
Apr 250.88
Apr 250.7
Apr 250.68
Mar 250.9
Mar 250.68
Mar 250.65
Mar 250.64
Feb 250.64
Feb 250.69
Feb 250.67
Feb 250.68
Jan 250.71
Jan 250.72
Jan 250.75
Jan 250.81
Jan 250.91
Dec 240.85
Dec 240.79
Dec 240.88
Dec 240.97
Nov 240.94
Nov 240.96
Nov 240.97
Nov 240.88
Nov 240.79
Oct 240.89
Oct 240.86
Spero Therapeutics, Inc.
SPRO
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News: SPRO

Spero Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

globenewswire.com · 3 Sep 2026

Spero Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

CAMBRIDGE, Mass., Sept. 03, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced that the Compensation Committee of Spero's Board of Directors approved a grant, made on September 1, 2026, of an aggregate of 102,000 restricted stock unit awards (RSUs) and 67,600 stock options to new employees under the Spero Therapeutics, Inc. 2019 Inducement Equity Incentive Plan, as amended (2019 Inducement Plan).

Spero Therapeutics to Present at H.C. Wainwright 28th Annual Global Investment Conference

globenewswire.com · 2 Sep 2026

Spero Therapeutics to Present at H.C. Wainwright 28th Annual Global Investment Conference

CAMBRIDGE, Mass., Sept. 02, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced that Esther Rajavelu, President and Chief Executive Officer, will present at the H.C.

Spero Therapeutics, Inc. (SPRO) Q2 2026 Earnings Call Transcript

seekingalpha.com · 12 Aug 2026

Spero Therapeutics, Inc. (SPRO) Q2 2026 Earnings Call Transcript

Spero Therapeutics, Inc. (SPRO) Q2 2026 Earnings Call Transcript

Spero Therapeutics Q2 Earnings Call Highlights

marketbeat.com · 12 Aug 2026

Spero Therapeutics Q2 Earnings Call Highlights

Spero Therapeutics NASDAQ: SPRO used its second-quarter update to outline a strategic shift toward immune-mediated diseases, supported by the FDA approval of Utebzi and a new licensing agreement for SP001, an antibody candidate the company plans to develop initially for IgG4-related disease.

Spero Therapeutics Announces Second Quarter 2026 Operating Results and Provides Business Update

globenewswire.com · 12 Aug 2026

Spero Therapeutics Announces Second Quarter 2026 Operating Results and Provides Business Update

CAMBRIDGE, Mass., Aug. 12, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced financial results for the second quarter ended June 30, 2026, and provided a corporate update.

Spero Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

globenewswire.com · 5 Aug 2026

Spero Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

CAMBRIDGE, Mass., Aug. 05, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced that on July 22, 2026, the Compensation Committee of Spero's Board of Directors approved a grant, to be made on August 3rd, of an aggregate of 324,622 stock options and 162,311 restricted stock unit awards (RSUs) to a new employee under the Spero Therapeutics, Inc. 2019 Inducement Equity Incentive Plan, as amended (2019 Inducement Plan).

Spero Therapeutics to Report Second Quarter 2026 Financial Results and Provide Business Update on August 12, 2026

globenewswire.com · 4 Aug 2026

Spero Therapeutics to Report Second Quarter 2026 Financial Results and Provide Business Update on August 12, 2026

CAMBRIDGE, Mass., Aug. 04, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced that announced that it will report its financial results for the second quarter ended June 30, 2026 on Wednesday, August 12, 2026, after market close.

Spero Therapeutics Appoints Debra Jeske Zack, M.D., Ph.D., as Chief Medical Officer

globenewswire.com · 27 Jul 2026

Spero Therapeutics Appoints Debra Jeske Zack, M.D., Ph.D., as Chief Medical Officer

Dr. Zack brings more than 25 years of leadership in developing therapeutics for immune-mediated diseases Appointment strengthens Spero's clinical leadership team as the Company advances SP001, a Phase 2-ready third-generation anti-CD40L antibody for IgG4-related disease (IgG4-RD) and other immune-mediated conditions CAMBRIDGE, Mass., July 27, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced the appointment of Debra Jeske Zack, M.D.

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