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Septerna Inc

$38.51 +$10.53 (+37.63%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$37.75
Day Range
$37.56$40.01
Year Range
$14$51.1
Market Cap
1.74B
AVG Volume
405.49K
Trailing/Forward PE
-71.31/-
PEG ratio
-1.04
Dividend Yield
-
Next Earnings Date
2026-11-09
Primary Exchange
NASDAQUS
Revenue (USD)
020M40M60M20242025
SEPN Revenue (USD) by year
PeriodRevenue (USD)
202545.95M
20241.07M
Net Income (USD)
-80M-60M-40M-20M020242025
SEPN Net Income (USD) by year
PeriodNet Income (USD)
2025-48.88M
2024-71.8M
Operating Income (USD)
-100M-75M-50M-25M020242025
SEPN Operating Income (USD) by year
PeriodOperating Income (USD)
2025-68.3M
2024-80.82M
EBITDA (USD)
-80M-60M-40M-20M020242025
SEPN EBITDA (USD) by year
PeriodEBITDA (USD)
2025-65.32M
2024-70.89M
Cash Flows (USD)
-100M-50M050M100M150M20242025
SEPN Cash Flows (USD) by year
PeriodCash Flows (USD)
2025109.67M
2024-69.57M
EPS (USD)
-2-1.5-1-0.5020242025
SEPN EPS (USD) by year
PeriodEPS (USD)
2025-1.11
2024-1.86
Expenses (USD)
050M100M150MR&DSG&ACapex20242025
SEPN Expenses (USD) by year
PeriodExpenses (USD)
2025127.27M
202484M
Cash & Debt (USD)
0100M200M300M400M20242025
SEPN Cash & Debt (USD) by year
PeriodCash & Debt (USD)
2025391.09M
2024350.92M
Debt ratios
0510152020242025
SEPN Debt ratios by year
PeriodDebt ratios
20251.39
202418.54
Margins
0%50%100%150%20242025
SEPN Margins by year
PeriodMargins
2025100%
2024100%
Return on Capital
-20%-15%-10%-5%0%20242025
SEPN Return on Capital by year
PeriodReturn on Capital
2025-12.8%
2024-17.09%
Shares Outstanding
020M40M60M20242025
SEPN Shares Outstanding by year
PeriodShares Outstanding
202544.26M
202432.38M
Book Value Per Share (USD)
05101520242025
SEPN Book Value Per Share (USD) by year
PeriodBook Value Per Share (USD)
20258.63
202412.97
Total Assets (USD)
0200M400M600M20242025
SEPN Total Assets (USD) by year
PeriodTotal Assets (USD)
2025596.19M
2024456.55M
Employee Count
05010015020242025
SEPN Employee Count by year
PeriodEmployee Count
2025130
202475
Free Cash Flow Yield
-40%-20%0%20%med -5.57%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
SEPN Free Cash Flow Yield by year
PeriodFree Cash Flow Yield
Sep 266.06%
Sep 266.35%
Aug 266%
Aug 265.83%
Aug 265.24%
Aug 266.15%
Jul 266.93%
Jul 267.22%
Jul 267.15%
Jul 266.65%
Jul 267.03%
Jun 266.4%
Jun 266.61%
Jun 266.65%
Jun 267.67%
May 267.91%
May 268.42%
May 268.86%
May 2610.38%
May 2610.5%
Apr 2610.04%
Apr 269.48%
Apr 2610.73%
Apr 269.84%
Mar 2610.38%
Mar 2610.25%
Mar 269.86%
Mar 268.08%
Feb 268.02%
Feb 268.53%
Feb 268.46%
Feb 269.15%
Jan 269.97%
Jan 269.03%
Jan 268.92%
Jan 269.19%
Jan 268.31%
Dec 258.13%
Dec 257.86%
Dec 259.14%
Dec 258.69%
Nov 258.02%
Nov 259.1%
Nov 2510%
Nov 25-10.16%
Oct 25-9.13%
Oct 25-8.68%
Oct 25-8.52%
Oct 25-8.15%
Oct 25-9.09%
Sep 25-10.77%
Sep 25-11.97%
Sep 25-13.17%
Sep 25-13.03%
Aug 25-15.54%
Aug 25-15.68%
Aug 25-16.04%
Aug 25-14.76%
Aug 25-14.13%
Jul 25-12.43%
Jul 25-13.75%
Jul 25-14.71%
Jul 25-15.18%
Jun 25-16.42%
Jun 25-16.48%
Jun 25-16.97%
Jun 25-16.9%
May 25-18.66%
May 25-18.78%
May 25-17.54%
May 25-32.11%
May 25-28.72%
Apr 25-33.26%
Apr 25-36.41%
Apr 25-37.56%
Apr 25-39.2%
Mar 25-35.22%
Mar 25-23.34%
Mar 25-21.93%
Mar 25-21.49%
Feb 25-21.36%
Feb 25-23.82%
Feb 25-10.66%
Feb 25-10.56%
Jan 25-8.17%
Jan 25-7.48%
Jan 25-8.18%
Jan 25-7.68%
Jan 25-5.83%
Dec 24-5.46%
Dec 24-5.69%
Dec 24-6.17%
Dec 24-5.37%
Nov 24-5.46%
Nov 24-6.28%
Nov 24-5.39%
Nov 24-4.68%
Nov 24-5.57%
Oct 24-5.67%
Price to Sales
050010001500med 201.53Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
SEPN Price to Sales by year
PeriodPrice to Sales
Sep 2617.54
Sep 2616.74
Aug 2617.72
Aug 2618.22
Aug 2620.27
Aug 2624.05
Jul 2621.34
Jul 2620.5
Jul 2620.69
Jul 2622.26
Jul 2621.06
Jun 2623.13
Jun 2622.41
Jun 2622.27
Jun 2619.3
May 2618.71
May 2617.57
May 2616.69
May 2622.99
May 2622.74
Apr 2623.76
Apr 2625.17
Apr 2622.24
Apr 2624.25
Mar 2622.99
Mar 2623.29
Mar 2624.21
Mar 2657.89
Feb 2658.37
Feb 2654.87
Feb 2655.32
Feb 2651.11
Jan 2646.95
Jan 2651.84
Jan 2652.44
Jan 2650.89
Jan 2656.28
Dec 2557.57
Dec 2559.5
Dec 2551.17
Dec 2553.83
Nov 2558.37
Nov 2551.41
Nov 2546.81
Nov 251126.03
Oct 251253.17
Oct 251318.26
Oct 251341.99
Oct 251403.43
Oct 251258.04
Sep 251061.55
Sep 25955.09
Sep 25868.7
Sep 25877.83
Aug 25736.09
Aug 25729.39
Aug 25712.97
Aug 25525.72
Aug 25549.11
Jul 25624.21
Jul 25564.4
Jul 25527.52
Jul 25511.33
Jun 25472.65
Jun 25470.85
Jun 25457.36
Jun 25459.16
May 25415.99
May 25413.29
May 25442.52
May 25201.53
May 25225.33
Apr 25194.6
Apr 25177.73
Apr 25172.31
Apr 25165.08
Mar 25183.76
Mar 25253.47
Mar 25269.74
Mar 25275.31
Feb 25277.02
Feb 25248.33
Feb 25554.9
Feb 25560.47
Jan 25724.02
Jan 25791.25
Jan 25723.17
Jan 25770.27
Jan 251014.32
Dec 241084.54
Dec 241039.58
Dec 24958.66
Dec 241102.52
Nov 241082.82
Nov 24941.96
Nov 241129.26
Nov 241298.68
Nov 241092.17
Oct 241072.63
Price/Operating Cashflow
7.51012.51517.520med 11.83Nov 25Jan 26Feb 26Apr 26Jun 26Jul 26Sep 26
SEPN Price/Operating Cashflow by year
PeriodPrice/Operating Cashflow
Sep 2616.36
Sep 2615.61
Aug 2616.53
Aug 2617
Aug 2618.91
Aug 2616.11
Jul 2614.29
Jul 2613.73
Jul 2613.86
Jul 2614.9
Jul 2614.1
Jun 2615.49
Jun 2615
Jun 2614.91
Jun 2612.92
May 2612.53
May 2611.76
May 2611.18
May 269.59
May 269.48
Apr 269.91
Apr 2610.5
Apr 269.27
Apr 2610.11
Mar 269.59
Mar 269.71
Mar 2610.1
Mar 2612.25
Feb 2612.35
Feb 2611.61
Feb 2611.7
Feb 2610.81
Jan 269.93
Jan 2610.96
Jan 2611.09
Jan 2610.76
Jan 2611.9
Dec 2512.18
Dec 2512.59
Dec 2510.82
Dec 2511.39
Nov 2512.35
Nov 2510.88
Nov 259.9
Price to Book
0246med 2.77Jun 25Aug 25Nov 25Jan 26Apr 26Jun 26Sep 26
SEPN Price to Book by year
PeriodPrice to Book
Sep 264.49
Sep 264.28
Aug 264.53
Aug 264.66
Aug 265.18
Aug 264.59
Jul 264.07
Jul 263.91
Jul 263.95
Jul 264.25
Jul 264.02
Jun 264.42
Jun 264.28
Jun 264.25
Jun 263.68
May 263.57
May 263.35
May 263.19
May 262.77
May 262.74
Apr 262.86
Apr 263.03
Apr 262.68
Apr 262.92
Mar 262.77
Mar 262.8
Mar 262.91
Mar 263.28
Feb 263.31
Feb 263.11
Feb 263.14
Feb 262.9
Jan 262.66
Jan 262.94
Jan 262.97
Jan 262.89
Jan 263.19
Dec 253.26
Dec 253.37
Dec 252.9
Dec 253.05
Nov 253.31
Nov 252.92
Nov 252.65
Nov 252.17
Oct 252.41
Oct 252.53
Oct 252.58
Oct 252.7
Oct 252.42
Sep 252.04
Sep 251.84
Sep 251.67
Sep 251.69
Aug 251.42
Aug 251.4
Aug 251.37
Aug 251.28
Aug 251.34
Jul 251.52
Jul 251.38
Jul 251.29
Jul 251.25
Jun 251.15
Jun 251.15
Jun 251.12
Jun 251.12
May 251.02
May 251.01
May 251.08
May 250.52
May 250.58
Apr 250.5
Apr 250.45
Apr 250.44
Apr 250.42
Mar 250.47
Septerna Inc
SEPN
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News: SEPN

Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

globenewswire.com · 10 Sep 2026

Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

SOUTH SAN FRANCISCO, Calif., Sept. 10, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), today announced that the Company granted a non-qualified stock option to purchase up to 275,000 shares of the Company's common stock to Rajiv Patni, M.D., the Company's newly appointed Chief Medical Officer, under the Company's 2026 Inducement Plan (the “Inducement Plan”). The inducement grant was effective as of September 8, 2026. The award was granted as an inducement material to Dr. Patni's employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4).

Septerna to Participate in Upcoming Investor Conferences

globenewswire.com · 1 Sep 2026

Septerna to Participate in Upcoming Investor Conferences

SOUTH SAN FRANCISCO, Calif., Sept. 01, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced that management will participate in the following investor conferences in September:

Septerna: GPCR Programs May Be Experimental, But I'm Holding For The Long Term

seekingalpha.com · 28 Aug 2026

Septerna: GPCR Programs May Be Experimental, But I'm Holding For The Long Term

Septerna, Inc. has surged >315% since May 2025, driven by its GPCR-focused drug discovery and a high-profile collaboration with Novo Nordisk. The SEPT partnership with NOVO targets GLP-1, GIP, and glucagon receptors, with $26.7m Q2 collaboration revenue and a new R&D program initiated. SEP-479, an oral small molecule for hypoparathyroidism, is a differentiated asset with a pivotal Q1 2027 data readout as a key catalyst.

Septerna Appoints Industry Veteran Rajiv Patni, M.D., as Chief Medical Officer

globenewswire.com · 25 Aug 2026

Septerna Appoints Industry Veteran Rajiv Patni, M.D., as Chief Medical Officer

SOUTH SAN FRANCISCO, Calif., Aug. 25, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced the appointment of Rajiv Patni, M.D., as Chief Medical Officer. Dr. Patni is a physician-scientist and accomplished biopharmaceutical executive with more than 25 years of experience leading research, development, regulatory, and medical affairs organizations.

Septerna, Inc. (SEPN) Reports Q2 Loss, Beats Revenue Estimates

zacks.com · 10 Aug 2026

Septerna, Inc. (SEPN) Reports Q2 Loss, Beats Revenue Estimates

Septerna, Inc. (SEPN) came out with a quarterly loss of $0.29 per share versus the Zacks Consensus Estimate of a loss of $0.48. This compares to a loss of $0.56 per share a year ago.

Septerna's Chief People Officer Sold Nearly 12,000 Company Shares. What Does That Mean for Investors?

fool.com · 5 Jul 2026

Septerna's Chief People Officer Sold Nearly 12,000 Company Shares. What Does That Mean for Investors?

Samira Shaikhly sold 11,798 shares of Common Stock on May 26, 2026, for a transaction value of ~$355,000. The transaction reduced direct Common Stock holdings by 93.7%, leaving 793 shares directly owned post-sale.

Is Septerna a Stock to Sell After an Insider Let Go of 15,000 Shares?

fool.com · 29 Jun 2026

Is Septerna a Stock to Sell After an Insider Let Go of 15,000 Shares?

15,000 shares were exercised and sold for a total of ~$533,000 on June 22, 2026, at a weighted average price of around $35.51 per share. This transaction impacted 13.46% of Long's direct Common Stock holdings, reducing his position to 96,412 shares.

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