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Septerna Inc

$38.51 +$10.53 (+37.63%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$37.75
Day Range
$37.56$40.01
Year Range
$14$51.1
Market Cap
1.74B
AVG Volume
405.49K
Trailing/Forward PE
-71.31/-
PEG ratio
-1.04
Dividend Yield
-
Next Earnings Date
2026-11-09
Primary Exchange
NASDAQUS
Revenue (USD)
010M20M30M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Revenue (USD) by quarter
PeriodRevenue (USD)
26 Q226.75M
26 Q126.52M
25 Q424.12M
25 Q321.5M
25 Q2119K
25 Q1219K
24 Q4212K
24 Q3176K
24 Q2370K
24 Q1317K
Net Income (USD)
-30M-20M-10M010M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Net Income (USD) by quarter
PeriodNet Income (USD)
26 Q2-13.03M
26 Q1-8.64M
25 Q4-10.74M
25 Q38.17M
25 Q2-24.84M
25 Q1-21.48M
24 Q4-20.67M
24 Q3-20.52M
24 Q2-16.44M
24 Q1-14.17M
Operating Income (USD)
-30M-20M-10M010M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Operating Income (USD) by quarter
PeriodOperating Income (USD)
26 Q2-16.84M
26 Q1-13.3M
25 Q4-16.02M
25 Q32.61M
25 Q2-28.98M
25 Q1-25.91M
24 Q4-24.72M
24 Q3-22.55M
24 Q2-18.07M
24 Q1-15.49M
EBITDA (USD)
-30M-20M-10M024 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN EBITDA (USD) by quarter
PeriodEBITDA (USD)
26 Q2-12.06M
26 Q1-7.88M
25 Q4-10.32M
25 Q3-9.48M
25 Q2-24.43M
25 Q1-21.08M
24 Q4-20.44M
24 Q3-20.3M
24 Q2-16.22M
24 Q1-13.94M
Cash Flows (USD)
-50M050M100M150M200M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Cash Flows (USD) by quarter
PeriodCash Flows (USD)
26 Q2-22.18M
26 Q1-26.46M
25 Q4-15.05M
25 Q3168.79M
25 Q2-20.34M
25 Q1-23.73M
24 Q4-21.57M
24 Q3-17.39M
24 Q2-13.14M
24 Q1-17.48M
EPS (USD)
-0.75-0.5-0.2500.2524 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN EPS (USD) by quarter
PeriodEPS (USD)
26 Q2-0.29
26 Q1-0.19
25 Q4-0.24
25 Q30.18
25 Q2-0.56
25 Q1-0.49
24 Q4-0.64
24 Q3-0.49
24 Q2-0.39
24 Q1-0.34
Expenses (USD)
020M40M60MR&DSG&ACapex24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Expenses (USD) by quarter
PeriodExpenses (USD)
26 Q243.58M
26 Q140.23M
25 Q440.21M
25 Q331.39M
25 Q229.16M
25 Q126.51M
24 Q425.54M
24 Q323.3M
24 Q218.58M
24 Q116.57M
Cash & Debt (USD)
0200M400M600M24 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Cash & Debt (USD) by quarter
PeriodCash & Debt (USD)
26 Q2372.32M
26 Q1347.4M
25 Q4391.09M
25 Q3474.35M
25 Q2326.56M
25 Q1336M
24 Q4350.92M
24 Q3130.53M
24 Q2148.84M
Debt ratios
02.557.51024 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Debt ratios by quarter
PeriodDebt ratios
26 Q28.8
26 Q16.22
25 Q45.63
25 Q35.97
25 Q23.5
25 Q13.99
24 Q44.59
24 Q31.66
24 Q22.53
Margins
0%25%50%75%100%24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Margins by quarter
PeriodMargins
26 Q2100%
26 Q198.41%
25 Q4100%
25 Q3100%
25 Q2100%
25 Q1100%
24 Q4100%
24 Q3100%
24 Q2100%
24 Q1100%
Return on Capital
-10%0%10%20%30%24 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Return on Capital by quarter
PeriodReturn on Capital
26 Q2-3.37%
26 Q1-2.28%
25 Q4-2.81%
25 Q32.1%
25 Q2-6.58%
25 Q1-5.37%
24 Q4-4.92%
24 Q323.48%
24 Q224.26%
Shares Outstanding
020M40M60M24 Q124 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Shares Outstanding by quarter
PeriodShares Outstanding
26 Q245.04M
26 Q144.76M
25 Q444.26M
25 Q344.34M
25 Q244.17M
25 Q143.94M
24 Q432.38M
24 Q342M
24 Q242M
24 Q142M
Book Value Per Share (USD)
-505101524 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Book Value Per Share (USD) by quarter
PeriodBook Value Per Share (USD)
26 Q28.59
26 Q18.46
25 Q48.63
25 Q38.77
25 Q28.55
25 Q19.11
24 Q412.97
24 Q3-2.08
24 Q2-1.61
Total Assets (USD)
0200M400M600M800M24 Q224 Q324 Q425 Q125 Q225 Q325 Q426 Q126 Q2
SEPN Total Assets (USD) by quarter
PeriodTotal Assets (USD)
26 Q2566.74M
26 Q1569.69M
25 Q4596.19M
25 Q3606.65M
25 Q2415.23M
25 Q1434.02M
24 Q4456.55M
24 Q3174.28M
24 Q2176.63M
Employee Count
05010015020242025
SEPN Employee Count by quarter
PeriodEmployee Count
2025130
202475
Free Cash Flow Yield
-40%-20%0%20%med -5.57%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
SEPN Free Cash Flow Yield by quarter
PeriodFree Cash Flow Yield
Sep 266.06%
Sep 266.35%
Aug 266%
Aug 265.83%
Aug 265.24%
Aug 266.15%
Jul 266.93%
Jul 267.22%
Jul 267.15%
Jul 266.65%
Jul 267.03%
Jun 266.4%
Jun 266.61%
Jun 266.65%
Jun 267.67%
May 267.91%
May 268.42%
May 268.86%
May 2610.38%
May 2610.5%
Apr 2610.04%
Apr 269.48%
Apr 2610.73%
Apr 269.84%
Mar 2610.38%
Mar 2610.25%
Mar 269.86%
Mar 268.08%
Feb 268.02%
Feb 268.53%
Feb 268.46%
Feb 269.15%
Jan 269.97%
Jan 269.03%
Jan 268.92%
Jan 269.19%
Jan 268.31%
Dec 258.13%
Dec 257.86%
Dec 259.14%
Dec 258.69%
Nov 258.02%
Nov 259.1%
Nov 2510%
Nov 25-10.16%
Oct 25-9.13%
Oct 25-8.68%
Oct 25-8.52%
Oct 25-8.15%
Oct 25-9.09%
Sep 25-10.77%
Sep 25-11.97%
Sep 25-13.17%
Sep 25-13.03%
Aug 25-15.54%
Aug 25-15.68%
Aug 25-16.04%
Aug 25-14.76%
Aug 25-14.13%
Jul 25-12.43%
Jul 25-13.75%
Jul 25-14.71%
Jul 25-15.18%
Jun 25-16.42%
Jun 25-16.48%
Jun 25-16.97%
Jun 25-16.9%
May 25-18.66%
May 25-18.78%
May 25-17.54%
May 25-32.11%
May 25-28.72%
Apr 25-33.26%
Apr 25-36.41%
Apr 25-37.56%
Apr 25-39.2%
Mar 25-35.22%
Mar 25-23.34%
Mar 25-21.93%
Mar 25-21.49%
Feb 25-21.36%
Feb 25-23.82%
Feb 25-10.66%
Feb 25-10.56%
Jan 25-8.17%
Jan 25-7.48%
Jan 25-8.18%
Jan 25-7.68%
Jan 25-5.83%
Dec 24-5.46%
Dec 24-5.69%
Dec 24-6.17%
Dec 24-5.37%
Nov 24-5.46%
Nov 24-6.28%
Nov 24-5.39%
Nov 24-4.68%
Nov 24-5.57%
Oct 24-5.67%
Price to Sales
050010001500med 201.53Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
SEPN Price to Sales by quarter
PeriodPrice to Sales
Sep 2617.54
Sep 2616.74
Aug 2617.72
Aug 2618.22
Aug 2620.27
Aug 2624.05
Jul 2621.34
Jul 2620.5
Jul 2620.69
Jul 2622.26
Jul 2621.06
Jun 2623.13
Jun 2622.41
Jun 2622.27
Jun 2619.3
May 2618.71
May 2617.57
May 2616.69
May 2622.99
May 2622.74
Apr 2623.76
Apr 2625.17
Apr 2622.24
Apr 2624.25
Mar 2622.99
Mar 2623.29
Mar 2624.21
Mar 2657.89
Feb 2658.37
Feb 2654.87
Feb 2655.32
Feb 2651.11
Jan 2646.95
Jan 2651.84
Jan 2652.44
Jan 2650.89
Jan 2656.28
Dec 2557.57
Dec 2559.5
Dec 2551.17
Dec 2553.83
Nov 2558.37
Nov 2551.41
Nov 2546.81
Nov 251126.03
Oct 251253.17
Oct 251318.26
Oct 251341.99
Oct 251403.43
Oct 251258.04
Sep 251061.55
Sep 25955.09
Sep 25868.7
Sep 25877.83
Aug 25736.09
Aug 25729.39
Aug 25712.97
Aug 25525.72
Aug 25549.11
Jul 25624.21
Jul 25564.4
Jul 25527.52
Jul 25511.33
Jun 25472.65
Jun 25470.85
Jun 25457.36
Jun 25459.16
May 25415.99
May 25413.29
May 25442.52
May 25201.53
May 25225.33
Apr 25194.6
Apr 25177.73
Apr 25172.31
Apr 25165.08
Mar 25183.76
Mar 25253.47
Mar 25269.74
Mar 25275.31
Feb 25277.02
Feb 25248.33
Feb 25554.9
Feb 25560.47
Jan 25724.02
Jan 25791.25
Jan 25723.17
Jan 25770.27
Jan 251014.32
Dec 241084.54
Dec 241039.58
Dec 24958.66
Dec 241102.52
Nov 241082.82
Nov 24941.96
Nov 241129.26
Nov 241298.68
Nov 241092.17
Oct 241072.63
Price/Operating Cashflow
7.51012.51517.520med 11.83Nov 25Jan 26Feb 26Apr 26Jun 26Jul 26Sep 26
SEPN Price/Operating Cashflow by quarter
PeriodPrice/Operating Cashflow
Sep 2616.36
Sep 2615.61
Aug 2616.53
Aug 2617
Aug 2618.91
Aug 2616.11
Jul 2614.29
Jul 2613.73
Jul 2613.86
Jul 2614.9
Jul 2614.1
Jun 2615.49
Jun 2615
Jun 2614.91
Jun 2612.92
May 2612.53
May 2611.76
May 2611.18
May 269.59
May 269.48
Apr 269.91
Apr 2610.5
Apr 269.27
Apr 2610.11
Mar 269.59
Mar 269.71
Mar 2610.1
Mar 2612.25
Feb 2612.35
Feb 2611.61
Feb 2611.7
Feb 2610.81
Jan 269.93
Jan 2610.96
Jan 2611.09
Jan 2610.76
Jan 2611.9
Dec 2512.18
Dec 2512.59
Dec 2510.82
Dec 2511.39
Nov 2512.35
Nov 2510.88
Nov 259.9
Price to Book
0246med 2.77Jun 25Aug 25Nov 25Jan 26Apr 26Jun 26Sep 26
SEPN Price to Book by quarter
PeriodPrice to Book
Sep 264.49
Sep 264.28
Aug 264.53
Aug 264.66
Aug 265.18
Aug 264.59
Jul 264.07
Jul 263.91
Jul 263.95
Jul 264.25
Jul 264.02
Jun 264.42
Jun 264.28
Jun 264.25
Jun 263.68
May 263.57
May 263.35
May 263.19
May 262.77
May 262.74
Apr 262.86
Apr 263.03
Apr 262.68
Apr 262.92
Mar 262.77
Mar 262.8
Mar 262.91
Mar 263.28
Feb 263.31
Feb 263.11
Feb 263.14
Feb 262.9
Jan 262.66
Jan 262.94
Jan 262.97
Jan 262.89
Jan 263.19
Dec 253.26
Dec 253.37
Dec 252.9
Dec 253.05
Nov 253.31
Nov 252.92
Nov 252.65
Nov 252.17
Oct 252.41
Oct 252.53
Oct 252.58
Oct 252.7
Oct 252.42
Sep 252.04
Sep 251.84
Sep 251.67
Sep 251.69
Aug 251.42
Aug 251.4
Aug 251.37
Aug 251.28
Aug 251.34
Jul 251.52
Jul 251.38
Jul 251.29
Jul 251.25
Jun 251.15
Jun 251.15
Jun 251.12
Jun 251.12
May 251.02
May 251.01
May 251.08
May 250.52
May 250.58
Apr 250.5
Apr 250.45
Apr 250.44
Apr 250.42
Mar 250.47
Septerna Inc
SEPN
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News: SEPN

Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

globenewswire.com · 10 Sep 2026

Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

SOUTH SAN FRANCISCO, Calif., Sept. 10, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), today announced that the Company granted a non-qualified stock option to purchase up to 275,000 shares of the Company's common stock to Rajiv Patni, M.D., the Company's newly appointed Chief Medical Officer, under the Company's 2026 Inducement Plan (the “Inducement Plan”). The inducement grant was effective as of September 8, 2026. The award was granted as an inducement material to Dr. Patni's employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4).

Septerna to Participate in Upcoming Investor Conferences

globenewswire.com · 1 Sep 2026

Septerna to Participate in Upcoming Investor Conferences

SOUTH SAN FRANCISCO, Calif., Sept. 01, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced that management will participate in the following investor conferences in September:

Septerna: GPCR Programs May Be Experimental, But I'm Holding For The Long Term

seekingalpha.com · 28 Aug 2026

Septerna: GPCR Programs May Be Experimental, But I'm Holding For The Long Term

Septerna, Inc. has surged >315% since May 2025, driven by its GPCR-focused drug discovery and a high-profile collaboration with Novo Nordisk. The SEPT partnership with NOVO targets GLP-1, GIP, and glucagon receptors, with $26.7m Q2 collaboration revenue and a new R&D program initiated. SEP-479, an oral small molecule for hypoparathyroidism, is a differentiated asset with a pivotal Q1 2027 data readout as a key catalyst.

Septerna Appoints Industry Veteran Rajiv Patni, M.D., as Chief Medical Officer

globenewswire.com · 25 Aug 2026

Septerna Appoints Industry Veteran Rajiv Patni, M.D., as Chief Medical Officer

SOUTH SAN FRANCISCO, Calif., Aug. 25, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced the appointment of Rajiv Patni, M.D., as Chief Medical Officer. Dr. Patni is a physician-scientist and accomplished biopharmaceutical executive with more than 25 years of experience leading research, development, regulatory, and medical affairs organizations.

Septerna, Inc. (SEPN) Reports Q2 Loss, Beats Revenue Estimates

zacks.com · 10 Aug 2026

Septerna, Inc. (SEPN) Reports Q2 Loss, Beats Revenue Estimates

Septerna, Inc. (SEPN) came out with a quarterly loss of $0.29 per share versus the Zacks Consensus Estimate of a loss of $0.48. This compares to a loss of $0.56 per share a year ago.

Septerna's Chief People Officer Sold Nearly 12,000 Company Shares. What Does That Mean for Investors?

fool.com · 5 Jul 2026

Septerna's Chief People Officer Sold Nearly 12,000 Company Shares. What Does That Mean for Investors?

Samira Shaikhly sold 11,798 shares of Common Stock on May 26, 2026, for a transaction value of ~$355,000. The transaction reduced direct Common Stock holdings by 93.7%, leaving 793 shares directly owned post-sale.

Is Septerna a Stock to Sell After an Insider Let Go of 15,000 Shares?

fool.com · 29 Jun 2026

Is Septerna a Stock to Sell After an Insider Let Go of 15,000 Shares?

15,000 shares were exercised and sold for a total of ~$533,000 on June 22, 2026, at a weighted average price of around $35.51 per share. This transaction impacted 13.46% of Long's direct Common Stock holdings, reducing his position to 96,412 shares.

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