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Protagonist Therapeutics, Inc.

$146.99 +$59.81 (+68.60%)
NASDAQ · 14 Sep 2026 15:20 UTC
Previous Close
$148.18
Day Range
$146.87$150.08
Year Range
$57.9$160.81
Market Cap
9.45B
AVG Volume
639.67K
Trailing/Forward PE
121.11/-
PEG ratio
-1.1
Dividend Yield
-
Next Earnings Date
2026-11-05
Primary Exchange
NASDAQUS
Revenue (USD)
0200M400M600M2016201720182019202020212022202320242025
PTGX Revenue (USD) by year
PeriodRevenue (USD)
202546.02M
2024434.43M
202360M
202226.58M
202127.36M
202028.63M
2019231K
201830.93M
201720.06M
20160
Net Income (USD)
-200M0200M400M2016201720182019202020212022202320242025
PTGX Net Income (USD) by year
PeriodNet Income (USD)
2025-130.15M
2024275.19M
2023-78.95M
2022-127.39M
2021-125.55M
2020-66.15M
2019-77.19M
2018-38.92M
2017-36.96M
2016-37.18M
Operating Income (USD)
-200M0200M400M2016201720182019202020212022202320242025
PTGX Operating Income (USD) by year
PeriodOperating Income (USD)
2025-158.13M
2024252.84M
2023-93.65M
2022-131.37M
2021-126.75M
2020-64.52M
2019-80.52M
2018-42.27M
2017-37.9M
2016-32.67M
EBITDA (USD)
-200M0200M400M2016201720182019202020212022202320242025
PTGX EBITDA (USD) by year
PeriodEBITDA (USD)
2025-128.03M
2024282.3M
2023-75.64M
2022-122.37M
2021-124.59M
2020-62.07M
2019-73.23M
2018-41.74M
2017-37.49M
2016-32.35M
Cash Flows (USD)
-200M-100M0100M200M2016201720182019202020212022202320242025
PTGX Cash Flows (USD) by year
PeriodCash Flows (USD)
202557.67M
2024182.8M
2023-70.84M
2022-108.93M
2021-108.97M
2020-72.95M
2019-42.49M
2018-50.43M
20173.21M
2016-30.35M
EPS (USD)
-5-2.502.552016201720182019202020212022202320242025
PTGX EPS (USD) by year
PeriodEPS (USD)
2025-2.05
20244.2
2023-1.44
2022-2.51
2021-2.7
2020-2
2019-3
2018-1.72
2017-2.17
2016-3.94
Expenses (USD)
0100M200M300MR&DSG&ACapex2016201720182019202020212022202320242025
PTGX Expenses (USD) by year
PeriodExpenses (USD)
2025204.14M
2024182.94M
2023154.26M
2022157.07M
2021156.2M
202094.25M
201981.72M
201873.68M
201758.63M
201633.05M
Cash & Debt (USD)
0200M400M600MCashLong Term DebtShort Term Debt2016201720182019202020212022202320242025
PTGX Cash & Debt (USD) by year
PeriodCash & Debt (USD)
2025567.36M
2024418.91M
2023341.62M
2022237.35M
2021326.9M
2020305.81M
2019133.02M
2018128.85M
2017144M
201677.6M
Debt ratios
05101520182019202020212022202320242025
PTGX Debt ratios by year
PeriodDebt ratios
202512.74
202410.13
20230.89
20220.61
20211.06
20201.4
20190.63
20181.02
Margins
-1500%-1000%-500%0%500%201720182019202020212022202320242025
PTGX Margins by year
PeriodMargins
2025100%
2024100%
2023100%
202293.69%
202197.01%
2020100%
2019-1100.87%
2018100%
2017100%
Return on Capital
-100%-50%0%50%100%2016201720182019202020212022202320242025
PTGX Return on Capital by year
PeriodReturn on Capital
2025-21.17%
202440.75%
2023-23.45%
2022-59.09%
2021-41.85%
2020-23.66%
2019-96.53%
201827.71%
201736.39%
201657.56%
Shares Outstanding
020M40M60M80M2016201720182019202020212022202320242025
PTGX Shares Outstanding by year
PeriodShares Outstanding
202563.57M
202462.33M
202360.39M
202249.26M
202148.15M
202039.61M
201927.61M
201824.19M
201720.2M
201616.72M
Book Value Per Share (USD)
-10-50510152016201720182019202020212022202320242025
PTGX Book Value Per Share (USD) by year
PeriodBook Value Per Share (USD)
20259.67
202410.83
20235.58
20224.38
20216.23
20207.06
20192.9
2018-5.81
2017-5.03
2016-3.86
Total Assets (USD)
0200M400M600M800M2016201720182019202020212022202320242025
PTGX Total Assets (USD) by year
PeriodTotal Assets (USD)
2025669.89M
2024744.73M
2023357.95M
2022247.93M
2021347.69M
2020324.47M
2019154.92M
2018139.47M
2017163.73M
201693.99M
Employee Count
0501001502016201720182019202020212022202320242025
PTGX Employee Count by year
PeriodEmployee Count
2025132
2024126
2023112
2022105
2021118
202079
201973
201864
201755
201635
PE Ratio
050100150med 17Jul 24Oct 24Feb 25May 25Sep 25Dec 25Sep 26
PTGX PE Ratio by year
PeriodPE Ratio
Sep 26117.84
Sep 26115.89
Aug 26114.78
Aug 26122.73
Aug 26123.35
Aug 26116.01
Feb 26114.96
Feb 26113.2
Feb 26117.37
Jan 26113.63
Jan 26115.43
Jan 26113.89
Jan 26111.43
Jan 26121.1
Dec 25123.32
Dec 25119.53
Dec 25132.45
Dec 25124.53
Nov 25125.02
Nov 25118.63
Nov 25117.53
Nov 25110.49
Oct 2595.95
Oct 2591.36
Oct 2594.59
Oct 25106.18
Oct 2579.12
Sep 2582.28
Sep 2575.91
Sep 2571.84
Sep 2573.88
Aug 2572.07
Aug 2570.15
Aug 2568.43
Aug 2562.33
Aug 2560.32
Jul 2561.8
Jul 2562.17
Jul 2559.39
Jul 2557.2
Jun 2562.4
Jun 2559.77
Jun 2563.16
Jun 2560.93
May 2553.19
May 2551.16
May 2549.85
May 2548.15
May 2510.31
Apr 2510.08
Apr 2510.48
Apr 259.65
Apr 2510.07
Mar 2511.07
Mar 2511.92
Mar 2512.41
Mar 258.69
Feb 258.51
Feb 258.78
Feb 2513.98
Feb 2514.06
Jan 2513.67
Jan 2513.63
Jan 2513.31
Jan 2513.24
Jan 2514.31
Dec 2414.09
Dec 2415
Dec 2414.85
Dec 2415.21
Nov 2415.84
Nov 2416.8
Nov 2414.86
Nov 2416.71
Nov 2416.87
Oct 2417.05
Oct 2416.94
Oct 2416.26
Oct 2416.01
Sep 2416.07
Sep 2417.07
Sep 2416.96
Sep 2414.97
Aug 2415.47
Aug 2415.03
Aug 2414.93
Aug 2413.97
Aug 2414.02
Jul 2415.12
Jul 2413.35
Jul 2413.56
Jul 2412.66
Jun 2413.01
Jun 2412.11
Jun 2412.53
Jun 2413.06
May 2410.57
May 2411.42
May 2411.54
May 2410.6
Free Cash Flow Yield
-5%0%5%10%15%med 1.24%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
PTGX Free Cash Flow Yield by year
PeriodFree Cash Flow Yield
Sep 261.35%
Sep 261.38%
Aug 261.39%
Aug 261.3%
Aug 261.29%
Aug 261.37%
Jul 26-1.31%
Jul 26-1.31%
Jul 26-1.27%
Jul 26-1.36%
Jul 26-1.36%
Jun 26-1.47%
Jun 26-1.58%
Jun 26-1.63%
Jun 26-1.83%
May 26-1.79%
May 26-1.8%
May 26-1.75%
May 26-1.8%
May 260.92%
Apr 260.91%
Apr 260.86%
Apr 260.92%
Apr 260.87%
Mar 260.92%
Mar 260.92%
Mar 260.98%
Mar 260.99%
Feb 260.99%
Feb 261.21%
Feb 261.23%
Feb 261.18%
Jan 261.22%
Jan 261.2%
Jan 261.22%
Jan 261.25%
Jan 261.15%
Dec 251.13%
Dec 251.16%
Dec 251.05%
Dec 251.11%
Nov 251.11%
Nov 251.17%
Nov 251.18%
Nov 251.26%
Oct 250.74%
Oct 250.78%
Oct 250.75%
Oct 250.67%
Oct 250.9%
Sep 250.87%
Sep 250.94%
Sep 250.99%
Sep 250.97%
Aug 250.99%
Aug 251.02%
Aug 251.04%
Aug 251.14%
Aug 259.89%
Jul 259.66%
Jul 259.6%
Jul 2510.05%
Jul 2510.43%
Jun 259.56%
Jun 259.98%
Jun 259.45%
Jun 259.79%
May 2511.22%
May 2511.66%
May 2511.97%
May 2512.39%
May 256.44%
Apr 256.59%
Apr 256.34%
Apr 256.88%
Apr 256.6%
Mar 256%
Mar 255.57%
Mar 255.35%
Mar 257.65%
Feb 257.8%
Feb 257.57%
Feb 259.6%
Feb 259.54%
Jan 259.82%
Jan 259.85%
Jan 2510.08%
Jan 2510.14%
Jan 259.38%
Dec 249.53%
Dec 248.94%
Dec 249.03%
Dec 248.82%
Nov 248.47%
Nov 247.99%
Nov 249.03%
Nov 248.03%
Nov 248.05%
Oct 247.97%
Oct 248.02%
Price to Sales
050100150med 20.08Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
PTGX Price to Sales by year
PeriodPrice to Sales
Sep 2634.65
Sep 2634.07
Aug 2633.75
Aug 2636.08
Aug 2636.27
Aug 2634.11
Jul 26120.08
Jul 26119.62
Jul 26123.83
Jul 26115.49
Jul 26115.67
Jun 26107.11
Jun 2699.18
Jun 2696.48
Jun 2685.58
May 2687.5
May 2687.17
May 2689.8
May 2687.32
May 26135.9
Apr 26138.15
Apr 26146.42
Apr 26136.52
Apr 26143.38
Mar 26136.73
Mar 26136.59
Mar 26127.6
Mar 26127.23
Feb 26127.21
Feb 2625.23
Feb 2624.84
Feb 2625.75
Jan 2624.93
Jan 2625.33
Jan 2624.99
Jan 2624.45
Jan 2626.57
Dec 2527.06
Dec 2526.23
Dec 2529.06
Dec 2527.33
Nov 2527.43
Nov 2526.03
Nov 2525.79
Nov 2524.24
Oct 2523.87
Oct 2522.73
Oct 2523.53
Oct 2526.41
Oct 2519.68
Sep 2520.47
Sep 2518.89
Sep 2517.87
Sep 2518.38
Aug 2517.93
Aug 2517.45
Aug 2517.02
Aug 2515.51
Aug 2516.31
Jul 2516.71
Jul 2516.81
Jul 2516.06
Jul 2515.47
Jun 2516.87
Jun 2516.16
Jun 2517.08
Jun 2516.48
May 2514.38
May 2513.84
May 2513.48
May 2513.02
May 256.53
Apr 256.38
Apr 256.64
Apr 256.11
Apr 256.38
Mar 257.01
Mar 257.55
Mar 257.86
Mar 255.5
Feb 255.39
Feb 255.56
Feb 257.38
Feb 257.42
Jan 257.21
Jan 257.19
Jan 257.02
Jan 256.98
Jan 257.55
Dec 247.43
Dec 247.91
Dec 247.84
Dec 248.02
Nov 248.36
Nov 248.86
Nov 247.84
Nov 248.82
Nov 248.98
Oct 249.08
Oct 249.02
EV/EBITDA
050100150med 13.47Jul 24Oct 24Feb 25May 25Sep 25Dec 25Sep 26
PTGX EV/EBITDA by year
PeriodEV/EBITDA
Sep 26105.25
Sep 26103.35
Aug 26102.28
Aug 26109.99
Aug 26110.59
Aug 26103.47
Feb 2695.18
Feb 2693.54
Feb 2697.41
Jan 2693.94
Jan 2695.62
Jan 2694.19
Jan 2691.91
Jan 26100.87
Dec 25102.93
Dec 2599.42
Dec 25111.4
Dec 25104.05
Nov 25104.5
Nov 2598.58
Nov 2597.56
Nov 2591.03
Oct 2579.88
Oct 2575.58
Oct 2578.6
Oct 2589.47
Oct 2564.11
Sep 2567.07
Sep 2561.1
Sep 2557.27
Sep 2559.19
Aug 2557.49
Aug 2555.7
Aug 2554.08
Aug 2548.36
Aug 2547.12
Jul 2548.5
Jul 2548.85
Jul 2546.25
Jul 2544.2
Jun 2549.07
Jun 2546.6
Jun 2549.78
Jun 2547.69
May 2540.44
May 2538.54
May 2537.31
May 2535.72
May 258.6
Apr 258.38
Apr 258.77
Apr 257.96
Apr 258.37
Mar 259.35
Mar 2510.18
Mar 2510.65
Mar 257.02
Feb 256.85
Feb 257.11
Feb 2510.95
Feb 2511.03
Jan 2510.65
Jan 2510.61
Jan 2510.31
Jan 2510.23
Jan 2511.27
Dec 2411.05
Dec 2411.94
Dec 2411.8
Dec 2412.14
Nov 2412.75
Nov 2413.68
Nov 2411.81
Nov 2413.6
Nov 2413.15
Oct 2413.32
Oct 2413.22
Oct 2412.56
Oct 2412.31
Sep 2412.38
Sep 2413.35
Sep 2413.24
Sep 2411.31
Aug 2411.8
Aug 2411.38
Aug 2411.28
Aug 2410.35
Aug 2411.6
Jul 2412.66
Jul 2410.95
Jul 2411.16
Jul 2410.29
Jun 2410.62
Jun 249.76
Jun 2410.17
Jun 2410.68
May 248.27
May 249.09
May 249.21
May 248.3
Price/Operating Cashflow
050100150med 17.18Sep 24Jan 25Apr 25Aug 25Nov 25Feb 26Sep 26
PTGX Price/Operating Cashflow by year
PeriodPrice/Operating Cashflow
Sep 2674.47
Sep 2673.23
Aug 2672.54
Aug 2677.56
Aug 2677.95
Aug 2673.31
May 26108.44
Apr 26110.23
Apr 26116.83
Apr 26108.93
Apr 26114.4
Mar 26109.1
Mar 26108.99
Mar 26101.81
Mar 26101.51
Feb 26101.5
Feb 2680.62
Feb 2679.38
Feb 2682.3
Jan 2679.68
Jan 2680.95
Jan 2679.87
Jan 2678.14
Jan 2684.92
Dec 2586.48
Dec 2583.82
Dec 2592.88
Dec 2587.33
Nov 2587.67
Nov 2583.19
Nov 2582.42
Nov 2577.48
Oct 25126.28
Oct 25120.24
Oct 25124.48
Oct 25139.74
Oct 25104.13
Sep 25108.29
Sep 2599.9
Sep 2594.54
Sep 2597.22
Aug 2594.84
Aug 2592.32
Aug 2590.06
Aug 2582.03
Aug 2510.06
Jul 2510.31
Jul 2510.37
Jul 259.9
Jul 259.54
Jun 2510.41
Jun 259.97
Jun 2510.53
Jun 2510.16
May 258.87
May 258.53
May 258.31
May 258.03
May 2515.4
Apr 2515.06
Apr 2515.66
Apr 2514.43
Apr 2515.04
Mar 2516.54
Mar 2517.82
Mar 2518.54
Mar 2512.98
Feb 2512.72
Feb 2513.12
Feb 2510.37
Feb 2510.43
Jan 2510.14
Jan 2510.11
Jan 259.88
Jan 259.82
Jan 2510.61
Dec 2410.45
Dec 2411.13
Dec 2411.02
Dec 2411.28
Nov 2411.75
Nov 2412.46
Nov 2411.03
Nov 2412.4
Nov 2412.38
Oct 2412.51
Oct 2412.44
Oct 2411.94
Oct 2411.75
Sep 2411.8
Sep 2412.53
Sep 2412.45
Sep 2410.99
Aug 2411.36
Aug 2411.04
Aug 2410.96
Aug 2410.25
May 1844.49
Apr 1846
Apr 1846.47
Price to Book
051015med 6.29Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
PTGX Price to Book by year
PeriodPrice to Book
Sep 2611.61
Sep 2611.42
Aug 2611.31
Aug 2612.09
Aug 2612.15
Aug 2611.43
Jul 2613.57
Jul 2613.52
Jul 2613.99
Jul 2613.05
Jul 2613.07
Jun 2612.1
Jun 2611.21
Jun 2610.9
Jun 269.67
May 269.89
May 269.85
May 2610.15
May 269.87
May 2610.17
Apr 2610.34
Apr 2610.96
Apr 2610.22
Apr 2610.73
Mar 2610.24
Mar 2610.23
Mar 269.55
Mar 269.52
Feb 269.52
Feb 268.18
Feb 268.05
Feb 268.35
Jan 268.08
Jan 268.21
Jan 268.1
Jan 267.93
Jan 268.61
Dec 258.77
Dec 258.5
Dec 259.42
Dec 258.86
Nov 258.89
Nov 258.44
Nov 258.36
Nov 257.86
Oct 257.47
Oct 257.12
Oct 257.37
Oct 258.27
Oct 256.16
Sep 256.41
Sep 255.91
Sep 255.6
Sep 255.75
Aug 255.61
Aug 255.46
Aug 255.33
Aug 254.86
Aug 254.92
Jul 255.04
Jul 255.07
Jul 254.84
Jul 254.66
Jun 255.09
Jun 254.87
Jun 255.15
Jun 254.97
May 254.34
May 254.17
May 254.07
May 253.93
May 254.2
Apr 254.11
Apr 254.27
Apr 253.93
Apr 254.1
Mar 254.51
Mar 254.86
Mar 255.06
Mar 253.54
Feb 253.47
Feb 253.58
Feb 254.49
Feb 254.51
Jan 254.39
Jan 254.38
Jan 254.28
Jan 254.25
Jan 254.6
Dec 244.52
Dec 244.82
Dec 244.77
Dec 244.88
Nov 245.09
Nov 245.4
Nov 244.77
Nov 245.37
Nov 245.3
Oct 245.35
Oct 245.32
Protagonist Therapeutics, Inc.
PTGX
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News: PTGX

Protagonist Therapeutics (NASDAQ:PTGX) CEO Sells $9,289,446.64 in Stock

defenseworld.net · 13 Sep 2026

Protagonist Therapeutics (NASDAQ:PTGX) CEO Sells $9,289,446.64 in Stock

Protagonist Therapeutics, Inc. (NASDAQ: PTGX - Get Free Report) CEO Dinesh Ph Patel sold 63,548 shares of the company's stock in a transaction dated Wednesday, September 9th. The stock was sold at an average price of $146.18, for a total transaction of $9,289,446.64. Following the completion of the sale, the chief executive officer directly owned 522,968

Protagonist Therapeutics (NASDAQ:PTGX) CEO Sells $7,902,361.38 in Stock

defenseworld.net · 13 Sep 2026

Protagonist Therapeutics (NASDAQ:PTGX) CEO Sells $7,902,361.38 in Stock

Protagonist Therapeutics, Inc. (NASDAQ: PTGX - Get Free Report) CEO Dinesh Ph Patel sold 54,174 shares of the company's stock in a transaction that occurred on Tuesday, September 8th. The shares were sold at an average price of $145.87, for a total transaction of $7,902,361.38. Following the completion of the sale, the chief executive officer directly

Hsbc Holdings PLC Purchases 24,045 Shares of Protagonist Therapeutics, Inc. $PTGX

defenseworld.net · 11 Sep 2026

Hsbc Holdings PLC Purchases 24,045 Shares of Protagonist Therapeutics, Inc. $PTGX

Hsbc Holdings PLC raised its position in Protagonist Therapeutics, Inc. (NASDAQ: PTGX) by 1,260.9% during the second quarter, according to its most recent filing with the Securities and Exchange Commission (SEC). The firm owned 25,952 shares of the company's stock after purchasing an additional 24,045 shares during the quarter. Hsbc Holdings PLC's holdings

Protagonist Therapeutics, Inc. (PTGX) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript

seekingalpha.com · 9 Sep 2026

Protagonist Therapeutics, Inc. (PTGX) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript

Protagonist Therapeutics, Inc. (PTGX) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript

Protagonist Therapeutics Announces $300 Million Share Repurchase Program

accessnewswire.com · 8 Sep 2026

Protagonist Therapeutics Announces $300 Million Share Repurchase Program

NEWARK, CA / ACCESS Newswire / September 8, 2026 / Protagonist Therapeutics, Inc. (Nasdaq:PTGX) today announced that its Board of Directors has authorized a share repurchase program under which the Company may repurchase up to $300 million of its outstanding common stock. The Company intends to fund the share repurchases from its cash, cash equivalents, and marketable securities, and from royalties and other payments received under the Company's collaboration arrangements with Takeda related to MIMRYLOTM (rusfertide) and with Johnson & Johnson related to ICOTYDETM (icotrokinra).

Protagonist Therapeutics to Participate in Two Investment Bank Conferences in September 2026

accessnewswire.com · 2 Sep 2026

Protagonist Therapeutics to Participate in Two Investment Bank Conferences in September 2026

NEWARK, CA / ACCESS Newswire / September 2, 2026 / Protagonist Therapeutics (NASDAQ:PTGX) ("Protagonist" or "the Company") today announced that Dinesh V. Patel, Ph.D.

Protagonist Therapeutics, Inc. (PTGX) Discusses FDA Approval of Mimrylo for Erythrocytosis in Polycythemia Vera Transcript

seekingalpha.com · 31 Aug 2026

Protagonist Therapeutics, Inc. (PTGX) Discusses FDA Approval of Mimrylo for Erythrocytosis in Polycythemia Vera Transcript

Protagonist Therapeutics, Inc. (PTGX) Discusses FDA Approval of Mimrylo for Erythrocytosis in Polycythemia Vera Transcript

Protagonist Wins FDA Approval for MIMRYLO in Rare Blood Cancer Treatment

marketbeat.com · 31 Aug 2026

Protagonist Wins FDA Approval for MIMRYLO in Rare Blood Cancer Treatment

Protagonist Therapeutics NASDAQ: PTGX said the U.S. Food and Drug Administration has approved rusfertide, to be marketed as MIMRYLO, for the treatment of erythrocytosis in adults with polycythemia vera, or PV.

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