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Ensysce Biosciences, Inc.

$0.49 -$0.45 (-48.20%)
NASDAQ · 11 Sep 2026 20:00 UTC
Previous Close
$0.52
Day Range
$0.48$0.52
Year Range
$0.23$2.75
Market Cap
7.48M
AVG Volume
11.52M
Trailing/Forward PE
-0.18/-
PEG ratio
0
Dividend Yield
-
Next Earnings Date
2026-11-13
Primary Exchange
NASDAQUS
Revenue (USD)
02M4M6M20182019202020212022202320242025
ENSC Revenue (USD) by year
PeriodRevenue (USD)
20250
20245.21M
20232.23M
20222.52M
20213.53M
20203.93M
20190
20180
Net Income (USD)
-30M-20M-10M010M20182019202020212022202320242025
ENSC Net Income (USD) by year
PeriodNet Income (USD)
2025-10.18M
2024-7.99M
2023-10.61M
2022-24.27M
2021-29.04M
202056.77K
2019820.38K
20182.12M
Operating Income (USD)
-30M-20M-10M020182019202020212022202320242025
ENSC Operating Income (USD) by year
PeriodOperating Income (USD)
2025-10.24M
2024-6.73M
2023-10.72M
2022-24.22M
2021-19.83M
2020-1.61M
2019-3.33M
2018-1.54M
EBITDA (USD)
-30M-20M-10M010M20182019202020212022202320242025
ENSC EBITDA (USD) by year
PeriodEBITDA (USD)
2025-10.16M
2024-6.7M
2023-10.27M
2022-25.05M
2021-18.71M
2020-1.61M
2019336.73K
20182.68M
Cash Flows (USD)
-50M050M100M150M20182019202020212022202320242025
ENSC Cash Flows (USD) by year
PeriodCash Flows (USD)
2025-7.93M
2024-7.5M
2023-10.78M
2022-17.89M
2021-8.49M
2020135.15M
201911.98M
2018198.28K
EPS (USD)
-400-300-200-100010020182019202020212022202320242025
ENSC EPS (USD) by year
PeriodEPS (USD)
2025-3.98
2024-4.99
2023-5.48
2022-173.52
2021-305.55
202017.33
20190.24
20180.35
Expenses (USD)
-10M010M20M30MR&DSG&ACapex20182019202020212022202320242025
ENSC Expenses (USD) by year
PeriodExpenses (USD)
202515.43M
202411.94M
202312.95M
202226.74M
202123.36M
20205.54M
20191.93M
20180
Cash & Debt (USD)
0100M200M300MCashLong Term DebtShort Term Debt20182019202020212022202320242025
ENSC Cash & Debt (USD) by year
PeriodCash & Debt (USD)
20254.31M
20243.5M
20231.12M
20223.15M
202112.26M
2020194.21K
20191.06M
2018204.57M
Debt ratios
-0.3-0.2-0.1-00.120212022202320242025
ENSC Debt ratios by year
PeriodDebt ratios
20250.08
20240.05
20230
2022-0.03
2021-0.29
Margins
-800%-600%-400%-200%0%20202021202220232024
ENSC Margins by year
PeriodMargins
2024-38.56%
2023-240.17%
2022-678.7%
2021-31.69%
2020-11.66%
Return on Capital
-500%0%500%1000%1500%2000%20182019202020212022202320242025
ENSC Return on Capital by year
PeriodReturn on Capital
2025-352.74%
2024-236.29%
20231629.6%
2022602.4%
2021356.01%
2020-0.85%
20190.44%
201842.44%
Shares Outstanding
02M4M6M8M20182019202020212022202320242025
ENSC Shares Outstanding by year
PeriodShares Outstanding
20252.56M
20241.23M
20232.26M
2022534.51K
2021100.37K
20204.46M
20196.08M
20186M
Book Value Per Share (USD)
-100-5005020182019202020212022202320242025
ENSC Book Value Per Share (USD) by year
PeriodBook Value Per Share (USD)
20251.13
20242.75
2023-0.29
2022-7.54
2021-81.28
2020-1.49
201930.61
20180.83
Total Assets (USD)
0100M200M300M20182019202020212022202320242025
ENSC Total Assets (USD) by year
PeriodTotal Assets (USD)
20257.45M
20245.6M
20232.71M
20225.89M
202116.42M
2020351.81K
2019196.51M
2018204.83M
Employee Count
0246820172018201920212022202320242025
ENSC Employee Count by year
PeriodEmployee Count
20258
20247
20237
20227
20216
20194
20184
20174
PE Ratio
01000000200000030000004000000med 88728.14Jan 19Apr 19Aug 19Nov 19Mar 20Apr 21Aug 21
ENSC PE Ratio by year
PeriodPE Ratio
Aug 216932.4
Aug 218982.53
Jul 2111941.48
Jul 2114794.55
Jul 2120606.98
Jul 2124983.06
Jul 2130646.28
Jun 2130223.58
Jun 2127560.52
Jun 2133816.59
Jun 213112511.68
May 213915375.73
May 213813604.23
May 213725967.66
May 213646812.05
Apr 213598753.29
Apr 213595926.3
Apr 213593099.31
Apr 213647942.84
Apr 213635504.1
Mar 213782507.38
Mar 213906894.77
May 20277832.8
Apr 20277565.91
Apr 20275697.68
Apr 20275430.79
Apr 20291177.32
Mar 20272495
Mar 20273562.56
Mar 20276231.46
Mar 2079410.27
Feb 2079755.53
Feb 2080292.6
Feb 2079947.34
Feb 2080024.07
Jan 2079870.62
Jan 2079947.34
Jan 2079947.34
Jan 2080024.07
Jan 2080100.79
Dec 1979333.54
Dec 1979333.54
Dec 1979333.54
Dec 1979563.72
Nov 1979180.09
Nov 1979103.37
Nov 1978873.19
Nov 1978873.19
Nov 1975943.9
Oct 1975747.59
Oct 1975574.89
Oct 1975663.45
Oct 1975796.3
Sep 1975574.89
Sep 1975427.28
Sep 1975427.28
Sep 1975521.01
Aug 1975434.66
Aug 1975427.28
Aug 1975427.28
Aug 1975427.28
Aug 1988989.87
Jul 1988989.87
Jul 1988989.87
Jul 1988553.65
Jul 1988640.89
Jun 1988728.14
Jun 1988728.14
Jun 1988379.16
Jun 1988291.91
May 1988304.13
May 1988117.42
May 1988117.42
May 1987681.2
May 19102481.67
Apr 19102654.8
Apr 19102553.97
Apr 19102858.48
Apr 19102451.12
Mar 19102206.7
Mar 19101840.08
Mar 19101636.39
Mar 19156993.69
Mar 19156678.44
Feb 19157466.56
Feb 19157466.56
Feb 19155259.82
Feb 19156678.44
Jan 19156205.57
Jan 19156363.19
Jan 19156363.19
Jan 19154786.95
Dec 18154629.33
Dec 18154944.57
Dec 18154629.33
Dec 18153683.58
Nov 18153841.2
Nov 18153525.96
Nov 18154471.7
Nov 18153210.71
Free Cash Flow Yield
-1000%-750%-500%-250%0%med -184.85%Dec 24Apr 25Jul 25Oct 25Feb 26May 26Sep 26
ENSC Free Cash Flow Yield by year
PeriodFree Cash Flow Yield
Sep 26-141.47%
Sep 26-151.15%
Aug 26-172.24%
Aug 26-184.52%
Aug 26-172.24%
Aug 26-273.3%
Jul 26-561.93%
Jul 26-543.87%
Jul 26-502.72%
Jul 26-526.74%
Jul 26-500.59%
Jun 26-472.48%
Jun 26-524.03%
Jun 26-565.96%
Jun 26-559.5%
May 26-505.94%
May 26-446.23%
May 26-507.56%
May 26-885.57%
May 26-797.24%
Apr 26-748.74%
Apr 26-620.25%
Apr 26-667.66%
Apr 26-508.74%
Mar 26-470.85%
Mar 26-425.22%
Mar 26-610.25%
Mar 26-453.98%
Feb 26-398.54%
Feb 26-624.84%
Feb 26-570.97%
Feb 26-538.3%
Jan 26-342.02%
Jan 26-289.14%
Jan 26-295.01%
Jan 26-243.5%
Jan 26-264.23%
Dec 25-225.79%
Dec 25-214.11%
Dec 25-173.69%
Dec 25-151.45%
Nov 25-140.32%
Nov 25-156.21%
Nov 25-120.57%
Nov 25-136.63%
Oct 25-129.11%
Oct 25-126.22%
Oct 25-118.26%
Oct 25-125.1%
Oct 25-110.81%
Sep 25-125.65%
Sep 25-132.14%
Sep 25-133.4%
Sep 25-132.14%
Aug 25-134.67%
Aug 25-137.3%
Aug 25-137.3%
Aug 25-189.94%
Aug 25-201.99%
Jul 25-184.85%
Jul 25-194.4%
Jul 25-191.7%
Jul 25-179.25%
Jun 25-184.85%
Jun 25-204.98%
Jun 25-200.03%
Jun 25-173.98%
May 25-186.52%
May 25-188.21%
May 25-176.95%
May 25-281.32%
May 25-237.54%
Apr 25-185.55%
Apr 25-346.86%
Apr 25-300.73%
Apr 25-266.58%
Mar 25-187.84%
Mar 25-176.95%
Mar 25-156.93%
Mar 25-84.85%
Feb 25-79.03%
Feb 25-78.88%
Feb 25-73.44%
Feb 25-69.15%
Jan 25-62%
Jan 25-56.2%
Jan 25-54.82%
Jan 25-56.87%
Jan 25-46.55%
Dec 24-47.97%
Dec 24-52.59%
Dec 24-75.79%
Dec 24-52.01%
Nov 24-57.48%
Nov 24-66.04%
Nov 24-42.34%
Nov 24-44.56%
Nov 24-50.04%
Oct 24-91.89%
Oct 24-182.74%
Price to Sales
05101520med 2.44Aug 24Nov 24Mar 25Jun 25Oct 25Jan 26Sep 26
ENSC Price to Sales by year
PeriodPrice to Sales
Sep 265.45
Sep 265.1
Aug 264.48
Aug 264.18
Aug 264.48
Mar 261.17
Mar 261.29
Mar 260.9
Mar 261.21
Feb 261.38
Feb 260.88
Feb 260.96
Feb 261.02
Jan 261.61
Jan 261.9
Jan 261.86
Jan 262.26
Jan 262.08
Dec 252.44
Dec 252.57
Dec 253.17
Dec 253.63
Nov 253.92
Nov 253.52
Nov 254.56
Nov 250.96
Oct 251.02
Oct 251.04
Oct 251.11
Oct 251.05
Oct 251.18
Sep 251.04
Sep 250.99
Sep 250.98
Sep 250.99
Aug 250.97
Aug 250.96
Aug 250.96
Aug 250.62
Aug 250.59
Jul 250.64
Jul 250.61
Jul 250.62
Jul 250.66
Jun 250.64
Jun 250.58
Jun 250.59
Jun 250.68
May 250.63
May 250.63
May 250.67
May 250.51
May 250.61
Apr 250.78
Apr 250.42
Apr 250.48
Apr 250.54
Mar 250.77
Mar 250.81
Mar 250.92
Mar 252.28
Feb 252.44
Feb 252.45
Feb 252.63
Feb 252.79
Jan 253.12
Jan 253.44
Jan 253.52
Jan 253.4
Jan 254.15
Dec 244.03
Dec 243.67
Dec 242.55
Dec 243.71
Nov 243.36
Nov 242.92
Nov 244.56
Nov 2415.27
Nov 2413.6
Oct 247.4
Oct 243.72
Oct 243.72
Oct 244.67
Sep 246.02
Sep 246.73
Sep 246.82
Sep 247.82
Aug 248.27
Aug 249.22
Aug 248.45
Aug 246.87
Aug 248.27
Jul 247.85
Jul 247.98
Jul 248.44
Jul 248.43
Jun 249.29
Jun 249.17
Jun 249.53
Jun 2410
EV/EBITDA
0200000400000600000800000med 92929.44Sep 18Dec 18Apr 19Jul 19Oct 19Jan 20May 20
ENSC EV/EBITDA by year
PeriodEV/EBITDA
May 20676880.08
Apr 20676229.86
Apr 20671678.3
Apr 20671028.08
Apr 20709391.2
Mar 20663875.63
Mar 20666476.52
Mar 20672978.75
Mar 2092304.59
Feb 2092706.28
Feb 2093331.13
Feb 2092929.44
Feb 2093018.71
Jan 2092840.18
Jan 2092929.44
Jan 2092929.44
Jan 2093018.71
Jan 2093107.97
Dec 1992215.33
Dec 1992215.33
Dec 1992215.33
Dec 1992483.12
Nov 1992036.8
Nov 1991947.53
Nov 1991679.74
Nov 1991679.74
Nov 1968909.52
Oct 1968731.22
Oct 1968574.37
Oct 1968654.81
Oct 1968775.46
Sep 1968574.37
Sep 1968440.31
Sep 1968440.31
Sep 1968525.44
Aug 1968447.02
Aug 1968440.31
Aug 1968440.31
Aug 1968440.31
Aug 1970398.48
Jul 1970398.48
Jul 1970398.48
Jul 1970053.07
Jul 1970122.15
Jun 1970191.24
Jun 1970191.24
Jun 1969914.91
Jun 1969845.83
May 1969855.5
May 1969707.66
May 1969707.66
May 1969362.25
May 1981191.72
Apr 1981329.01
Apr 1981249.06
Apr 1981490.53
Apr 1981167.49
Mar 1980973.67
Mar 1980682.94
Mar 1980521.42
Mar 19123188.51
Mar 19122941.15
Feb 19123559.57
Feb 19123559.57
Feb 19121827.99
Feb 19122941.15
Jan 19122570.09
Jan 19122693.78
Jan 19122693.78
Jan 19121456.93
Dec 18121333.25
Dec 18121580.62
Dec 18121333.25
Dec 18120591.14
Nov 18120714.83
Nov 18120467.46
Nov 18121209.57
Nov 18120220.09
Nov 18202231.11
Oct 18202231.11
Oct 18202231.11
Oct 18202023.07
Oct 18202439.15
Sep 18202647.2
Sep 18201606.98
Sep 18201398.94
Sep 18201398.94
Aug 18201398.94
Aug 18201606.98
Aug 18201606.98
Aug 18201815.03
Aug 18201606.98
Price/Operating Cashflow
05000100001500020000med 1616.43Apr 20Jun 20Aug 20Nov 20Jan 21Mar 21Jun 21
ENSC Price/Operating Cashflow by year
PeriodPrice/Operating Cashflow
Jun 211307.46
May 211644.72
May 211601.97
May 211565.15
May 211531.9
Apr 211511.72
Apr 211510.53
Apr 211509.34
Apr 211532.38
Apr 211527.15
Mar 211588.91
Mar 211641.16
Mar 2124.27
Mar 2126.52
Feb 2124.22
Feb 2125.91
Feb 2127.43
Feb 2128.26
Jan 2121.38
Jan 2121.93
Jan 2121.43
Jan 2121.45
Dec 2021.37
Dec 2022.82
Dec 2019.34
Dec 2022
Dec 2018.73
Nov 2018.06
Nov 2018.05
Nov 2018
Nov 201690.47
Oct 201743.51
Oct 201730.71
Oct 201690.47
Oct 201689.02
Oct 201737.96
Sep 201682.43
Sep 201704.96
Sep 201685.64
Sep 201713.01
Aug 201682.42
Aug 201684.03
Aug 201677.59
Aug 201677.59
Jul 201613.34
Jul 201624.17
Jul 201678.3
Jul 201637.31
Jul 201672.1
Jun 201616.43
Jun 201935.46
Jun 201617.92
Jun 201699.96
May 201686.04
May 201611.91
May 201594.78
May 201610.24
May 2019017.89
Apr 2018999.63
Apr 2018871.74
Apr 2018853.47
Apr 2019931.34
Mar 2018652.52
Mar 2018725.59
Mar 2018908.28
Price to Book
051015med 1.79Aug 24Nov 24Mar 25Jun 25Oct 25Jan 26May 26
ENSC Price to Book by year
PeriodPrice to Book
May 260.31
May 260.34
Apr 260.37
Apr 260.44
Apr 260.41
Apr 260.54
Mar 261.74
Mar 261.93
Mar 261.34
Mar 261.81
Feb 262.06
Feb 261.31
Feb 261.44
Feb 261.52
Jan 262.4
Jan 262.83
Jan 262.78
Jan 263.37
Jan 263.1
Dec 253.63
Dec 253.83
Dec 254.72
Dec 255.41
Nov 255.84
Nov 255.25
Nov 256.8
Nov 251.48
Oct 251.57
Oct 251.6
Oct 251.71
Oct 251.62
Oct 251.83
Sep 251.61
Sep 251.53
Sep 251.52
Sep 251.53
Aug 251.5
Aug 251.48
Aug 251.48
Aug 251.12
Aug 251.06
Jul 251.15
Jul 251.1
Jul 251.11
Jul 251.19
Jun 251.15
Jun 251.04
Jun 251.07
Jun 251.23
May 251.14
May 251.13
May 251.21
May 250.79
May 250.93
Apr 251.2
Apr 250.64
Apr 250.74
Apr 250.83
Mar 251.18
Mar 251.25
Mar 251.41
Mar 251.53
Feb 251.64
Feb 251.65
Feb 251.77
Feb 251.88
Jan 252.09
Jan 252.31
Jan 252.37
Jan 252.28
Jan 252.79
Dec 242.71
Dec 242.47
Dec 241.71
Dec 242.5
Nov 242.26
Nov 241.97
Nov 243.07
Nov 2414.84
Nov 2413.21
Oct 247.2
Oct 243.62
Oct 243.62
Oct 244.54
Sep 245.85
Sep 246.55
Sep 246.63
Sep 247.6
Aug 248.04
Aug 248.96
Aug 248.21
Aug 243.51
Aug 244.22
Jul 244.01
Jul 244.07
Jul 244.31
Jul 244.31
Jun 244.74
Jun 244.68
Jun 244.87
Ensysce Biosciences, Inc.
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News: ENSC

Ensysce Biosciences Announces Upcoming Conference and Industry Event Participation

accessnewswire.com · 2 Sep 2026

Ensysce Biosciences Announces Upcoming Conference and Industry Event Participation

SAN DIEGO, CA / ACCESS Newswire / September 2, 2026 / Ensysce Biosciences, Inc. (NASDAQ:ENSC) ("Ensysce" or the "Company") a clinical-stage biotechnology company developing novel neuroplastogenic therapies beyond mood disorders, with an initial focus on CRPS (Complex Regional Pain Syndrome), today announced its participation in the following upcoming investors conferences and industry events. 2026 Cantor Global Healthcare Conference being held Wednesday, September 9th to Saturday, September 12th at the Waldorf Astoria in New York City.

Ensysce Biosciences Completes Final Phase of PF614-MPAR-102 Clinical Study

accessnewswire.com · 31 Aug 2026

Ensysce Biosciences Completes Final Phase of PF614-MPAR-102 Clinical Study

~ ~ The Second Study Fully Enrolled for Breakthrough Therapy-Designated, First-in-Class Opioid Designed to Protect Against Oral Overdose ~ ~ SAN DIEGO, CA / ACCESS Newswire / August 31, 2026 / Ensysce Biosciences, Inc. (NASDAQ:ENSC) ("Ensysce" or the "Company"), a biotechnology company developing novel neuroplastogenic therapies beyond mood disorders, with an initial focus on complex pain, and advancing next-generation pain and central nervous system therapeutics designed to reduce abuse and overdose risk, today announced completion of enrollment in the final stage of the PF614-MPAR-102 clinical study. The study evaluated its novel MPAR® (Multi-Pill Abuse Resistance) overdose-protection technology.

Ensysce Biosciences to Showcase "A New Era in Pain Therapeutics" at PAINWeek 2026 Symposium

accessnewswire.com · 20 Aug 2026

Ensysce Biosciences to Showcase "A New Era in Pain Therapeutics" at PAINWeek 2026 Symposium

~Major symposium to highlight breakthrough innovations in severe pain and Complex Regional Pain Syndrome (CRPS) ~ ~Discussions to feature a first-in-class approach to neural reset and novel chemical safety switch technology ~ SAN DIEGO, CA / ACCESS Newswire / August 20, 2026 / Ensysce Biosciences, Inc. (NASDAQ:ENSC) ("Ensysce" or the "Company") a clinical-stage biotechnology company developing novel neuroplastogenic therapies beyond mood disorders, with an initial focus on complex pain, today announced that it will host an educational symposium at PAINWeek 2026, entitled A New Era in Pain Therapeutics. The symposium will present a vision for the future of pain management-one that introduces an entirely new therapeutic approach for one of medicine's most debilitating chronic pain conditions and one that combines effective analgesia with improved safety.

Ensysce Biosciences, Inc. (ENSC) Discusses Acquisition of Cy Biopharma and Private Placement Financing Prepared Remarks Transcript

seekingalpha.com · 18 Aug 2026

Ensysce Biosciences, Inc. (ENSC) Discusses Acquisition of Cy Biopharma and Private Placement Financing Prepared Remarks Transcript

Ensysce Biosciences, Inc. (ENSC) Discusses Acquisition of Cy Biopharma and Private Placement Financing Prepared Remarks Transcript

Ensysce Biosciences Reports Second Quarter 2026 Financial Results and Recent Business Highlights

accessnewswire.com · 13 Aug 2026

Ensysce Biosciences Reports Second Quarter 2026 Financial Results and Recent Business Highlights

Acquisition of Cy Biopharma Completed, Adding CY200 for Complex Regional Pain Syndrome Up to $77 million in new funding with the acquisition of Cy Biopharma Company to host a Corporate Update Call on Tuesday, August 18, 2026, at 11:00 a.m. ET SAN DIEGO, CA / ACCESS Newswire / August 13, 2026 / Ensysce Biosciences, Inc. (NASDAQ:ENSC) ("Ensysce" or the "Company"), a clinical-stage biotechnology company developing novel neuroplastogenic therapies beyond mood disorders, with an initial focus on complex pain, today reported financial and operational results for the second quarter ended June 30, 2026.

Ensysce Biosciences (NASDAQ:ENSC) versus CannAmerica Brands (OTCMKTS:CNNXF) Head to Head Review

defenseworld.net · 13 Aug 2026

Ensysce Biosciences (NASDAQ:ENSC) versus CannAmerica Brands (OTCMKTS:CNNXF) Head to Head Review

Ensysce Biosciences (NASDAQ: ENSC - Get Free Report) and CannAmerica Brands (OTCMKTS:CNNXF - Get Free Report) are both healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their profitability, risk, earnings, analyst recommendations, valuation, dividends and institutional ownership. Valuation and Earnings This table compares Ensysce Biosciences

Ensysce Biosciences Announces Acquisition of Cy Biopharma and up to $77 Million Private Financing

accessnewswire.com · 6 Aug 2026

Ensysce Biosciences Announces Acquisition of Cy Biopharma and up to $77 Million Private Financing

Acquisition includes clinical-stage neuroplastogenic therapy with U.S. FDA Orphan Drug Designation for the treatment of Complex Regional Pain Syndrome (CRPS) Up to $77 million in private financing consisting of $21.5 million in private placement financing at initial close plus $17.1 million of Cy Biopharma's cash and cash equivalents from a pre-acquisition convertible note financing and up to $38.6 million upon achievement of clinical trial milestone Pro forma cash expected to fund CY200 through Phase 2 proof-of-concept data and into registrational development SAN DIEGO, CA / ACCESS Newswire / August 6, 2026 / Ensysce Biosciences, Inc. (NASDAQ:ENSC) ("Ensysce" or the "Company") today announced it has completed the acquisition of Cy Biopharma, Inc. ("Cy Biopharma"), a privately held clinical-stage biotechnology company developing novel neuroplastogenic therapies beyond mood disorders, with an initial focus on complex pain. Concurrent with the acquisition that brought in $17.1 million in cash from a pre-acquisition convertible note financing, Ensysce entered into a definitive agreement for the sale of Series C non-voting convertible preferred stock (with a conversion ratio of preferred to common at 1:1,000) (the "Series C Preferred Stock") in a private placement financing, which is expected to result in gross proceeds to the Company of approximately $21.5 million at the initial close before deducting placement agent fees and other offering and transaction expenses, and includes up to a $38.6 million follow-on tranche that is expected to fund development of CY200 into 2028.

Ensysce Biosciences Awarded $5.3 Million Installment in NIDA Funding Completing Multi-Year $15 Million Federal Grant

accessnewswire.com · 14 Jul 2026

Ensysce Biosciences Awarded $5.3 Million Installment in NIDA Funding Completing Multi-Year $15 Million Federal Grant

Funds Advance FDA-Designated Breakthrough Therapy First-in-Class Opioid with Oral Overdose-Protection SAN DIEGO, CA / ACCESS Newswire / July 14, 2026 / Ensysce Biosciences, Inc. (NASDAQ:ENSC) ("Ensysce" or the "Company"), a clinical-stage pharmaceutical company pioneering next-generation pain and central nervous system therapeutics engineered to minimize abuse and overdose risk, today announced receipt of a Notice of Award for $5.3 million from the National Institutes on Drug Abuse (NIDA)1 to support the development of its novel MPAR® (Multi-Pill Abuse Resistance) overdose-protection technology, and the lead agent, PF614-MPAR. This marks the third consecutive year of NIDA funding under this award, reflecting sustained institutional confidence in the MPAR® program as it progresses toward late-stage development.

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